N-methyl-D-aspartate receptor antagonist MK-801 and radical scavengers protect cholinergic nucleus basalis neurons against β-amyloid neurotoxicity

Neurobiology of Disease

Volumn 6, Issue 2, 1999, Pages 109-121

  Harkany, T ^a,b   Mulder, J ^c   Sasvari M ^a   Abraham I ^d   Konya C ^b   Zarandi M ^e   Penke, B ^e   Luiten, P G M ^c   Nyakas, C ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b Trace Element Research Center   (Hungary)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

^d INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^e UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Cholinergic system; N methyl D aspartate receptor; Neuroprotection; Vitamin; amyloid

Indexed keywords

ACETYLCHOLINESTERASE; ALPHA TOCOPHEROL; AMYLOID BETA PROTEIN; ASCORBIC ACID; CHOLINE ACETYLTRANSFERASE; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SCAVENGER; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; MALE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OLIVARY NUCLEUS; PRIORITY JOURNAL; RAT; SCAVENGING SYSTEM;

EID: 0032901459     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.1998.0230     Document Type: Article

References (50)

1. Aizenman E., Hartnett K. A., Reynolds I. J. Oxygen free radicals regulate NMDA receptor function via a redox modulatory site. Neuron. 5:1990;841-846.
2. Barth A., Barth L., Newell D. W. Combined therapy with MK-801 and alpha-phenyl-tert-butyl-nitrone enhances protection against ischemic neuronal damage in organotypic hippocampal slice cultures. Exp. Neurol. 141:1996;330-336.
3. Behl C., Davis J. B., Lesley R., Schubert D. Hydrogen peroxide mediates amyloid β protein toxicity. Cell. 77:1994;817-827.
4. Chiba A. A., Bucci D. J., Holland P. C., Gallagher M. Basal forebrain cholinergic neurons disrupt increments but not decrements in conditioned stimulus processing. J. Neurosci. 15:1995;7315-7322.
5. Cowburn R. F., Wiehager B., Trief E., Li-Li M., Sundstrom E. Effects of β-amyloid-(25-35) peptides on radioligand binding to excitatory amino acid receptors and voltage-dependent calcium channels: Evidence for a selective affinity for the glutamate and glycine recognition sites of the NMDA receptor. Neurochem. Res. 22:1997;1437-1442.
6. Dutrait N., Culcasi M., Cazevieille C., Pietri S., Tordo P., Bonne C., Muller A. Calcium-dependent free radical generation in cultured retinal neurons induced by kainate. Neurosci. Lett. 198:1995;13-16.
7. Ellman G. L., Courtney K. D., Anders V., Featherstone R. M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7:1961;88-95.
8. Fernandes C., File S. E. The influence of open arm ledges and maze experience in the elevated plus-maze. Pharmacol. Biochem. Behav. 54:1996;31-40.
9. Flood J. F., Roberts E., Sherman M. A., Kaplan B. E., Morley J. E. Topography of a binding site for small amnestic peptides deduced from structure-activity studies: Relation to amnestic effect of amyloid β protein. Proc. Natl. Acad. Sci. USA. 91:1994;380-384.
10. Fonnum F. A rapid radiochemical method for the determination of choline acetyltransferase. J. Neurochem. 24:1975;407-409.
11. Forloni G., Tagliavini F., Bugiani O., Salmona M. Amyloid in Alzheimer's disease and prion-related encephalopathies: Studies with synthetic peptides. Prog. Neurobiol. 49:1996;287-315.
12. Furuta A., Price D. L., Pardo C. A., Troncoso J. C., Xu Z. S., Taniguchi N., Martin L. J. Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus. Am. J. Pathol. 146:1995;357-367.
13. Giovannelli L., Casamenti F., Scali C., Bartolini L., Pepeu G. Differential effects of amyloid peptides β-(1-40) and β-(25-35) injections into the rat nucleus basalis. Neuroscience. 66:1995;781-792.
14. Goodman Y., Mattson M. P. Secreted forms of β-amyloid precursor protein protect hippocampal neurons against amyloid β-peptide-induced oxidative injury. Exp. Neurol. 128:1994;1-12.
15. Gray W. C., Patel A. J. Neurodegeneration mediated by glutamate and β-amyloid peptide: A comparison and possible interaction. Brain. Res. 691:1995;169-179.
16. 2+. Soc. Neurosci. Abstr. 23:1997;1627.
17. (1-42). Brain. Res. 698:1995a;270-274.
18. (1-42). Brain. Res. 695:1995b;71-75.
19. 24. Behav. Brain. Res. 90:1998;133-145.
20. Kroemer G., Dallaporta B., Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu. Rev. Physiol. 60:1998;619-642.
21. Lafon-Cazal M., Pietri S., Culcasi M., Bockaert J. NMDA-dependent superoxide production and neurotoxicity. Nature. 364:1993;535-537.
22. i. Biochem. Biophys. Res. Commun. 235:1997;479-481.
23. Lei S. Z., Pan Z. H., Aggarwal S. K., Chen H. S., Hartman J., Sucher N. J., Lipton S. A. Effect of nitric oxide production on the redox modulatory site of the NMDA receptor channel complex. Neuron. 8:1992;1087-1099.
24. Lockhart B. P., Benicourt C., Junien J. L., Privat A. Inhibitors of free radical formation fail to attenuate direct β-amyloid25-35 peptide-mediated neurotoxicity in rat hippocampal cultures. J. Neurosci. Res. 39:1994;494-505.
25. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
26. 2+. Neurodegeneration. 4:1995;307-314.
27. Majewska M. D., Bell J. A., London E. D. Regulation of the NMDA receptor by redox phenomena: Inhibitory role of ascorbate. Brain. Res. 537:1990;328-332.
28. Mattson M. P. Secreted forms of β-amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neurons. J. Neurobiol. 25:1994;439-450.
29. Mattson M. P. Calcium and neuronal injury in Alzheimer's disease. Calcium Hypothesis of Aging and Dementia. 1995;New York Acad. Press. p. 50-76.
30. Mattson M. P. Modification of ion homeostasis by lipid peroxidation: Roles in neuronal degeneration and adaptive plasticity. Trends Neurosci. 21:1998;53-57.
31. Mattson M. P., Cheng B., Davis D., Bryant K., Lieberburg I., Rydel R. R. β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12:1992;376-389.
32. 2+. J. Neurochem. 65:1995;1740-1751.
33. Maurice T., Lockhart B. P., Su T. P., Privat A. Reversion of β 25-35-amyloid peptide-induced amnesia by NMDA receptor-associated glycine site agonists. Brain Res. 731:1996;249-253.
34. Medina L., Figueredo-Cardenas G., Reiner A. Differential abundance of superoxide dismutase in interneurons versus projection neurons and in matrix versus striosome neurons in monkey striatum. Brain Res. 708:1996;59-70.
35. Misra H. P., Fridovich I. The generation of superoxide radical during the autooxidation of hemoglobin. J. Biol. Chem. 247:1972;6960-6962.
36. Nyakas C., Buwalda B., Luiten P. G. M., Bohus B. Effect of low amphetamine doses on cardiac responses to emotional stress in aged rats. Neurobiol. Aging. 13:1991a;123-129.
37. Nyakas C., Markel E., Schuurman T., Luiten P. G. M. Impaired learning and abnormal open-field behaviours of rats after early postnatal anoxia and the beneficial effect of the calcium antagonist nimodipine. Eur. J. Neurosci. 3:1991b;168-174.
38. O'Mahony S., Harkany T., Rensink A. A. M., Ábrahám I., De Jong G. I., Varga J. L., Zarándi M., Penke B., Nyakas C., Luiten P. G. M., Leonard B. E. β-Amyloid-induced cholinergic denervation correlates with enhanced nitric oxide synthase activity in rat cerebral cortex: Reversal by NMDA receptor blockade. Brain. Res. Bull. 45:1998;405-411.
39. O'Neill M. J., Hicks C., Ward M. Neuroprotective effects of 7-nitroindazole in the gerbil model of global cerebral ischaemia. Eur. J. Pharmacol. 310:1996;115-122.
40. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1986;Academic Press, Sydney.
41. Pike C. J., Ramezan-Arab N., Cotman C. W. β-Amyloid neurotoxicityin vitro: J. Neurochem. 69:1997;1601-1611.
42. Robertson S. C., Wetjen N. M., Beer B. J., Loftus C. M. Pre- and postischemic effects of the NMDA receptor antagonist dizocilpine maleate (MK-801) on collateral cerebral blood flow. J. Neurosurg. 87:1997;927-933.
43. Sagara Y., Dargusch R., Klier F. G., Schubert D., Behl C. Increased antioxidant enzyme activity in amyloid β protein-resistant cells. J. Neurosci. 16:1996;497-505.
44. Shubert D., Behl C., Lesley R., Brack A., Dargusch R., Sagara Y., Kimura H. Amyloid peptides are toxic via a common oxidative mechanim. Proc. Natl. Acad. Sci. USA. 92:1995;1989-1993.
45. Sisodia S. S., Price D. L. Role of the β-amyloid protein in Alzheimer's disease. FASEB J. 9:1995;366-370.
46. Soto C., Barnes M. C., Alvarez J., Inestrosa N. C. Structural determinants of the Alzheimer's amyloid β-peptide. J. Neurochem. 63:1994;1191-1198.
47. Stuiver B. T., Douma B. R. K., Bakker R., Nyakas C., Luiten P. G. M. In vivo. Neurodegeneration. 5:1996;153-159.
48. Suo Z., Fang C., Crawford F., Mullan M. Superoxide free radical and intracellular calcium mediate Aβ(1-42) induced endothelial toxicity. Brain. Res. 762:1997;144-152.
49. Van der Zee E. A., Douma B. R. K., Bohus B., Luiten P. G. M. Passive avoidance training induces enhanced levels of immunoreactivity of muscarinic acetylcholine receptor and coexpressed PKCγ and MAP-2 in rat cortical neurons. Cereb. Cortex. 4:1994;376-390.
50. Yankner B. A., Duffy L. K., Kirschner D. A. Neurotrophic and neurotoxic effects of amyloid β protein: Reversal by tachykinin neuropeptides. Science. 250:1990;279-282.