Congopain from Trypanosoma congolense: Drug target and vaccine candidate

Biological Chemistry

Volumn 383, Issue 5, 2002, Pages 739-749

  Lalmanach, Gilles ^a   Boulangé, Alain ^a   Serveau, Carole ^a   Lecaille, Fabien ^a   Scharfstein, Julio ^a   Gauthier, Francis ^a   Authiè, Edith ^a  

^a UNIVERSITÉ DE TOURS   (France)

Author keywords

Anti disease vaccine; Congopain; Cysteine protease; Subsite specificity; Trypanosoma congolense; Trypanosome

Indexed keywords

ALPHA 2 MACROGLOBULIN; CATHEPSIN L; CONGOPAIN; CRUZIPAIN; CYSTEINE PROTEINASE; PAPAIN; PROTOZOAL VACCINE; PROTOZOON ANTIBODY; RECOMBINANT ANTIGEN; UNCLASSIFIED DRUG;

AFRICA; AFRICAN TRYPANOSOMIASIS; ANIMAL PARASITOSIS; CONTROLLED STUDY; DRUG DESIGN; DRUG TARGETING; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; HOST RANGE; IMMUNE RESPONSE; LIFE CYCLE; LIVESTOCK; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE DEVELOPMENT; PARASITE VIRULENCE; PRIORITY JOURNAL; REVIEW; TRYPANOSOMA CONGOLENSE; TRYPANOSOMIASIS; ANIMAL; ANIMAL DISEASE; BLOOD; CATTLE; CATTLE DISEASE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; IMMUNIZATION; IMMUNOLOGY; METABOLISM; PARASITOLOGY;

ANIMAL; ANTIBODIES, PROTOZOAN; CATALYTIC DOMAIN; CATTLE; CATTLE DISEASES; CYSTEINE ENDOPEPTIDASES; DRUG DESIGN; IMMUNIZATION; PROTOZOAN VACCINES; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T; TRYPANOSOMA CONGOLENSE; TRYPANOSOMIASIS, AFRICAN; ANIMALS;

ANIMALIA; MAMMALIA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CONGOLENSE; TRYPANOSOMA CRUZI;

EID: 0035985064     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2002.077     Document Type: Review

References (97)

1. Leishmania mexicana cysteine-deficient mutants have attenuated virulence for mice and potentiate a Th1 response
2. S1 subsite specificity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non-natural basic amino acids
3. Trypanosoma cruzi: Killing and enhanced uptake by resident peritoneal macrophages treated with α-2-macroglobulin
4. The C-terminal extension of the major cysteine proteinase (cruzipain) from Trypanosoma cruzi
5. Trypanosomiasis and trypanotolerance in cattle: A role for congopain?
6. Identification of a 33-kilodalton immunodominant antigen of Trypanosoma congolense as a cysteine protease
7. Antibody responses to non-variant antigens of Trypanosoma congolense in cattle of differing susceptibility to trypanosomiasis
8. Antibody responses to a cysteine protease of Trypanosoma congolense - Relationship to trypanotolerance in cattle
9. Immunisation of cattle with cysteine proteinases of Trypanosoma congolense: Targeting the disease rather than the parasite
10. Recent advances in identifying and validating drug targets in trypanosomes and leishmanias
11. The merops database as a protease information system
12. Alignment/phylogeny of the papain superfamily of cysteine proteases
13. Inactivation of human interleukin-2 (IL-2) by α-2-macroglobulin-trypsin complexes
14. Functional expression of the catalytic domains of two cysteine proteinases from Trypanosoma congolense
15. A target within the target: Probing cruzain's P1' site to define structural determinants for the Chagas' disease protease
16. Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense
17. The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is encoded by multiple polymorphic tandemly organised genes located on different chromosomes
18. Cruzipain, the major cysteine proteinase from the protozoan parasite Trypanosoma cruzi
19. The major cysteine proteinase of Trypanosoma cruzi: A valid target for chemotherapy of Chagas disease
20. A comparison of the enzymatic properties of the major cysteine proteinases from Trypanosoma congolense and Trypanosoma cruzi
21. Characterization of two cysteine proteinases secreted by Fasciola hepatica and demonstration of their kininogenase activity
22. Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment
23. α-2-Macroglobulin binds to the surface of Trypanosoma cruzi
24. Proregion structure of members of the papain superfamily. Mode of inhibition of enzymatic activity
25. Structure of rat procathepsin B: Model for inhibition of cysteine protease activity by the proregion
26. Parasite vaccines - A reality?
27. Kininogenase activity by the major cysteinyl proteinase (cruzipain) from Trypanosoma cruzi
28. Cathepsin L, but not cathepsin B, is a potential kininogenase
29. Genome research and evolution in trypanosomes
30. Aryl ureas represent a new class of anti-trypanosomal agents
31. The sequence, organization and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi
32. Primary structure and partial characterization of a life-cycle-regulated cysteine protease from Trypanosoma (Nannomonas) congolense
33. Potent slow-binding inhibition of cathepsin B by its propeptide
34. Structural determinants of specificity in the cysteine protease cruzain
35. Cystatin C-based peptidyldiazomethanes as cysteine proteinase inhibitors: Influence of the peptidyl length
36. New approaches to integrated control of trypanosomosis
37. Protease trafficking in two primitive eukaryotes is mediated by a prodomain protein motif
38. Thiol proteases. Comparative studies based on the high-resolution structures of papain and actinidin, and on amino acid sequence informations for cathepsins B and H, and stem bromelain
39. Two distinct gene subfamilies within the family of cysteine protease genes
40. Measuring the costs of African trypanosomosis, the potential benefits of control and returns to research
41. Interaction between cystatin-derived peptides and papain
42. Conserved cystatin segments as models for designing specific substrates and inhibitors of cysteine proteinases
43. Biotin-labelled peptidyl diazomethane inhibitors derived from the substrate-like sequence of cystatin: Targeting of the active site of cruzipain, the major cysteine proteinase of Trypanosoma cruzi
44. Inhibition of trypanosomal cysteine proteinases by their propeptides
45. Revisiting the S2 specificity of papain by structural analogs of Phe
46. Subsite specificity of trypanosomal cathepsin L-like cysteine proteases: Probing the S2 pocket with phenylalanine-derived amino acids
47. Reversible inhibition of cathepsin L-like proteases by 4-mer pseudopeptides
48. Temperature-dependent substrate inhibition of the cysteine proteinase (GP57/51) from Trypanosoma cruzi
49. Identification of new cysteine protease gene isoforms in Trypanosoma cruzi
50. Recombinant cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preferences and affinity for inhibitors
51. Heparan sulfate modulates kinin release by Trypanosoma cruzi through the activity of cruzipain
52. Trypanosomatid cysteine protease activity may be enhanced by a kininogen-like moiety from host serum
53. Trypanosoma congolense: Proliferative responses and interleukin production in lymph node cells of infected cattle
54. Trypanosoma congolense: Tissue localisation of long term T-cell and B-cell responses in N'Dama cattle
55. Trypanosoma congolense: A comparison of T-cell-mediated responses in lymph nodes of trypanotolerant ant trypanosusceptible cattle during primary infection
56. Noncovalent complexes between the lysosomal proteinase cathepsin B and its propeptide account for stable, extracellular, high molecular mass forms of the enzyme
57. Polymorphisms of the genes encoding cruzipain, the major cysteine proteinase of Trypanosoma cruzi, in the region encoding the C-terminal domain
58. Immunolocalization of a cysteine protease within the lysosomal system of Trypanosoma congolense
59. Characterization of a cysteine protease from blood-stream forms of Trypanosoma congolense
60. The lysosomal cysteine proteases
61. The crystal structure of cruzain : A therapeutic target for Chagas' disease
62. Crystal structure of human cathepsin K complexed with a potent inhibitor
63. The cysteine protease of Trypanosoma cruzi as a model for antiparasite drug design
64. Cysteine protease inhibitors as chemotherapy for parasitic infections
65. Identification, characterization and localization of chagasin, a tight-binding cysteine protease inhibitor in Trypanosoma cruzi
66. Human T cell responses against the major cysteine proteinase (cruzipain) of Trypanosoma cruzi: Role of the multifunctional α2-macroglobulin receptor in antigen presentation by monocytes
67. The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferences
68. Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions
69. Cathepsin L proteinases as vaccines against infection with Fasciola hepatica (liver fluke) in ruminants
70. Host susceptibility to African trypanosomosis: Trypanotolerance
71. Structural and functional identification of GP57/51 antigen of Trypanosoma cruzi as a cysteine proteinase
72. Cysteine proteases and their inhibitors
73. Vinyl sulfones as mechanism-based cysteine protease inhibitors
74. The malaria vaccine: Anti-parasite or anti-disease
75. Vaccination of BALB/c mice with Leishmania major amastigote-specific cysteine proteinase
76. Inhibitory effects of human alpha-2-macroglobulin on Trypanosoma cruzi epimastigotes
77. Proteases of protozoan parasites
78. Potent second generation of vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain
79. Trypanosoma cruzi: Characterization and isolation of a 57/51,000 m.w. surface glycoprotein (GP57/51) expressed by epimastigotes and bloodstream trypomastigotes
80. Host cell invasion by Trypanosoma cruzi is potentiated by activation of bradykinin B(2) receptors
81. Investigation of the substrate specificity of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, through the use of cystatin-derived substrates and inhibitors
82. Discrimination of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, and mammalian cathepsins B and L, by a pH-inducible fluorogenic substrate of trypanosomal cysteine proteinases
83. Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum
84. Crystal structure of human procathepsin X: A cysteine protease with the proregion covalently linked to the active site cysteine
85. The high stability of cruzipain against pH-induced inactivation is not dependent on its C-terminal domain
86. The proregion of cathepsin L is required for proper folding, stability and ER exit
87. Proteases from Trypanosoma brucei brucei. Purification, characterisation and interactions with host regulatory molecules
88. Cysteine proteinase inhibitors kill cultured bloodstream forms of Trypanosoma brucei brucei
89. Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei
90. Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitors
91. Lysosomal cysteine proteases: More than scavengers
92. Revised definition of substrate binding sites of papain-like cysteine proteases
93. Lysosomal cysteine proteases: Facts and opportunities
94. Secretion of functional papain precursor from insect cells. Requirement for N-glycosylation of the pro-region
95. Function of propeptide domains of cysteine proteinases
96. A cryptic protease activity from Trypanosoma cruzi revealed by preincubation with kininogen at low temperatures
97. Altered expression of cruzipain and a cathepsin B-like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases