Subsite specificity of trypanosomal cathepsin L-like cysteine proteases probing the S2 pocket with phenylalanine-derived amino acids

European Journal of Biochemistry

Volumn 268, Issue 9, 2001, Pages 2733-2741

  Lecaille, Fabien ^a,c   Authié, Edith ^b   Moreau, Thierry ^a   Serveau, Carole ^a   Gauthier, Francis ^a   Lalmanach, Gilles ^a  

^a UNIVERSITÉ DE TOURS   (France)

^b CIRAD   (France)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Cathepsins; Cysteine proteases; Fluorogenic substrates; Phe analogs; Trypanosomes

Indexed keywords

AMINO ACID DERIVATIVE; CARBENE; CATHEPSIN B; CATHEPSIN L; CONGOPAIN; CRUZIPAIN; CYCLOHEXYLALANINE; CYSTEINE PROTEINASE; DEXTRO PHENYLALANINE; KETONE DERIVATIVE; PAPAIN; PHENYLALANINE; PHENYLALANINE DERIVATIVE; PHENYLGLYCINE; PROTEIN INHIBITOR; PSEUDOPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; HALOGENATION; HYDROPHOBICITY; NITRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STEREOCHEMISTRY; TRYPANOSOMA CONGOLENSE; TRYPANOSOMA CRUZI;

ANIMALS; CATALYTIC DOMAIN; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; KINETICS; MODELS, MOLECULAR; OLIGOPEPTIDES; PHENYLALANINE; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; TRYPANOSOMA; TRYPANOSOMA CONGOLENSE; TRYPANOSOMA CRUZI;

EID: 0034850412     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.02172.x     Document Type: Article

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