Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a Th1 response

Journal of Immunology

Volumn 161, Issue 12, 1998, Pages 6794-6801

  Alexander, James ^a   Coombs, Graham H ^b   Mottram, Jeremy C ^b  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME DEFICIENCY; GENE MUTATION; IMMUNE RESPONSE; LEISHMANIA MEXICANA; LEISHMANIASIS; MOUSE; NONHUMAN; PARASITE VIRULENCE; PHENOTYPE; PRIORITY JOURNAL; SPLEEN CELL; VACCINATION;

ANIMALS; CONCANAVALIN A; CYSTEINE ENDOPEPTIDASES; GENE DELETION; IMMUNIZATION; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; LEISHMANIA MEXICANA; LEISHMANIASIS, CUTANEOUS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED CBA; PROTOZOAN PROTEINS; PROTOZOAN VACCINES; TH1 CELLS; TH2 CELLS; VACCINES, ATTENUATED; VIRULENCE;

EID: 0032534577     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Heinzel, F. P., D. S. Schoenhaut, R. M. Rerko, L. E. Rosser, and M. K. Gately. 1993. Recombinant interleukin-12 cures mice infected with Leishmania major. J. Exp. Med. 177:1505.
2. Sypek, J. P., C. L. Chung, S. E. H. Mayor, J. M. Subramanyam, S. J. Goldman, D. S. Sieburth, S. F. Wolf, and R. G. Schaub. 1993. Resolution of cutaneous leishmaniasis: inlerleukin-12 initiates a protective T helper type 1 immune response. J. Exp. Med. 177:1797.
3. Afonso, L. C. C., T. M. Scharton, L. Q. Vieira, M. Wysocka, G. Trinchieri, and P. Scott. 1994. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263:235.
4. Liew, F. Y., and C. A. O'Donnell. 1993. Immunology of leishmaniasis. Adv. Parasitol. 32:161.
5. Scharton-Kersten, T., L. C. C. Afonso, M. Wysocka, G. Trinchieri, and P. Scott. 1995. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J. Immunol. 154:5320.
6. + T cell subsets in experimental cutaneous leishmaniasis. Res. Immunol. 142:32.
7. Belosevic, M., D. S. Finbloom, P. H. Vandermeide, M. V. Slayter, and C. A. Nacy. 1989. Administration of monoclonal anti-IFN antibodies in vivo abrogates natural resistance of C3H/Hen mice to infection with Leishmania major. J. Immunol. 143:266.
8. Liew, F. Y., S. Millott, C. Parkinson, R. M. J. Palmer, and S. Moncada. 1990. Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine. J. Immunol. 144:4794.
9. Evans, T. G., L. Thai, D. L. Granger, and J. B. Hibbs. 1993. Effect of in vivo inhibition of nitric oxide production in murine leishmaniasis. J. Immunol. 151: 907.
10. Heinzel, F. P., M. D. Sadick, B. J. Holaday, R. L. Coffman, and R. M. Locksley. 1989. Reciprocal expression of interferon-or interleukin-4 during the resolution or progression of murine leishmaniasis: evidence for expansion of distinct helper T-cell subsets. J. Exp. Med. 169:59.
11. + subsets during murine Leishmania major infection. Res. Immunol. 142:28.
12. Satoskar, A., H. Bluethmann, and J. Alexander. 1995. Disruption of the murine interleukin-4 gene inhibits disease progression during Leishmania mexicana infection but does not increase control of Leishmania donovani infection. Infect. Immun. 63:4894.
13. Afonso, L. C. C., and P. Scott. 1993. Immune responses associated with susceptibility of C57BL/10 mice to Leishmania amazonensis. Infect. Immun. 61:2952.
14. Noben-Trauth, N., P. Kropf, and I. Müller. 1996. Susceptibility to Leishmania major infection in interleukin-4-deficient mice. Science 271:987.
15. Satoskar, A., and J. Alexander. 1995. Sex determined susceptibility and differential IFN-γ and TNF-α mRNA expression in DBA/2 mice infected with Leishmania mexicana. Immunology 84:1.
16. Roberts, M., J. Alexander, and J. M. Blackwell. 1989. Influence of Lsh, H-2, and an H-11-linked gene on visceralization and metastasis associated with Leishmania mexicana infection in mice. Infect. Immun. 57:875.
17. Finkelman, F. D., and J. F. Urban. 1992. Cytokines making the right choice. Parasitol. Today 8:311.
18. Coombs, G. H., and J. C. Mottram. 1997. Proteinases of trypanosomes and Leishmania. Trypanosomiasis and Leishmaniasis: Biology and Control. G. Hide, J. C. Mottram, G. H. Coombs, and P. H. Holmes, ed. CAB International, Oxford, U.K., p. 177.
19. Mottram, J. C., C. D. Robertson, G. H. Coombs, and J. D. Barry. 1992. A developmentally regulated cysteine proteinase gene of Leishmania mexicana. Mol. Microbiol. 6:1925.
20. Souza, A. E., S. Waugh, G. H. Coombs, and J. C. Mottram. 1992. Characterization of a multicopy gene for a major stage-specific cysteine proteinase of Leishmania mexicana. FEBS Lett. 311:124.
21. Bart, G., M. J. Frame, R. Carter, G. H. Coombs, and J. C. Mottram. 1997. Cathepsin B-like cysteine proteinase-deficient mutants of Leishmania mexicana. Mol. Biochem. Parasitol. 88:53.
22. Souza, A. E., P. A. Bates, G. H. Coombs, and J. C. Mottram. 1994. Null mutants for the lmcpa cysteine proteinase gene in Leishmania mexicana. Mol. Biochem. Parasitol. 63:213.
23. Mottram, J. C., A. E. Souza, J. E. Hutchison, R. Carter, M. J. Frame, and G. H. Coombs. 1996. Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors. Proc. Natl. Acad. Sci. USA 93:6008.
24. Lezama-Davila, C. M., D. M. Williams, G. Gallagher, and J. Alexander. 1992. Cytokine control of Leishmania infection in the BALB/c mouse: enhancement and inhibition of parasite growth by local administration of IL-2 or IL-4 is species and time dependent. Parasite Immunol. 14:37.
25. Russell, D. G., and J. Alexander. 1988. Effective immunization against cutaneous leishmaniasis with defined membrane antigens reconstituted into liposomes. J. Immunol. 140:1274.
26. Satoskar, A., F. Brombacher, W. J. Dai, I. McInnes, F. Y. Liew, J. Alexander, and W. Walker. 1997. SCID mice reconstituted with IL-4 deficient lymphocytes, but not immunocompetent lymphocytes, are resistant to cutaneous leishmaniasis. J. Immunol. 159:5005.
27. Heinzel, F. P., R. M. Rerko, F. Hatam, and R. M. Locksley. 1993. IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts. J. Immunol. 150:3924.
28. Murray, H. W., G. D. Miralles, M. Y. Stoeckle, and D. F. McDermott. 1993. Role and effect of IL-2 in experimental visceral leishmaniasis. J. Immunol. 151:929.
29. + T cell subsets in murine leishmaniasis. New Strategies in Parasitology. K. P. W. G. McAdam, ed. Ciba Foundation, London, p. 147.
30. Finkelman, F. D., J. Holmes, I. A. Katona, J. F. Urban, M. P. Beckman, L. S. Parks, K. A. Schooley, R. L. Coffman, T. R. Mosmann, and W. E. Paul. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8:303.
31. Doherty, T. M., and R. L. Coffman. 1996. Leishmania major: effect of infectious dose on T cell subset development in BALB/c mice. Exp. Parasitol. 84:124.
32. Schulz, O., P. Laing, H. E. Sewell, and F. Shakib. 1995. Der PI, a major allergen of the house dust mite, proteolytically cleaves the low affinity receptor for human IgE (CD23). Eur. J. Immunol. 25:3191.
33. McKerrow, J. H., and M. J. Doenhoff. 1988. Schistosome proteases. Parasitol. Today 4:334.
34. Pearce, E. J., P. Caspar, J. M. Grzych, F. A. Lewis, and A. Sher. 1991. Down-regulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J. Exp. Med. 173:159.
35. -. Eur. J. Immunol. 25:3298.
36. Mougneau, E., F. Altare, A. E. Wakil, S. Zheng, T. Coppola, Z.-E. Wang, R. Waldmann, R. M. Locksley, and N. Glaichenhaus. 1995. Expression cloning of a protective Leishmania antigen. Science 268:563.
37. Julia, V., M. Rassoulzadegan, and N. Glaichenhaus. 1996. Resistance to Leishmania major induced by tolerance to a single antigen. Science 274:421.
38. Wolfram, M., T. Ilg, J. C. Mottram, and P. Overath. 1995. Antigen presentation by Leishmania mexicana-infected macrophages: activation of helper T cells specific for amastigote cysteine proteinases requires intracellular killing of the parasites. Eur. J. Immunol. 25:1094.
39. De Souza Leao, S., T. Lang, E. Prina, R. Hellio, and J.-C. Antoine. 1995. Intracellular Leishmania amazonensis amastigotes internalize and degrade MHC class II molecules of their host cells. J. Cell Sci. 108:3219.
40. Brewer, J. M., J. Richmond, and J. Alexander. 1994. The demonstration of an essential role for macrophages in the in vivo generation of IgG2a antibodies. Clin. Exp. Immunol. 97:164.
41. Cruz, A., C. M. Coburn, and S. M. Beverley. 1991. Double targeted gene replacement for creating null mutants. Proc. Natl. Acad. Sci. USA 88:7170.
42. Titus, R. G., F. J. Gueiros-Filho, L. A. R. De Freitas, and S. M. Beverley. 1995. Development of a safe live Leishmania vaccine line by gene replacement. Proc. Natl. Acad. Sci. USA 92:102671.
43. Aebischer, T. 1994. Recurrent cutaneous leishmaniasis: a role for persistent parasites. Parasitol. Today 10:25.
44. Bogdan, C., A. Gessner, W. Solbach, and M. Röllinghoff. 1996. Invasion, control and persistence of Leishmania parasites. Curr. Opin. Immunol. 8:517.
45. Roberts, M., J. Alexander, and J. M. Blackwell. 1990. Genetic analysis of Leishmania mexicana infection in mice: single gene (Scl-2) controlled predisposition to cutaneous lesion development. J. Immunogenet. 17:89.