Anergy in peripheral memory CD4+ T cells induced by low avidity engagement of T cell receptor

Journal of Experimental Medicine

Volumn 194, Issue 6, 2001, Pages 719-731

  Mirshahidi, S ^a   Huang, C ^a   Sadegh Nasseri, S ^a  

^a Departments of Pediatrics Medicine Oncology and Radiation Oncology   (United States)

Author keywords

Antigen presentation; Autoimmunity; CTLA 4; T cell tolerance; Transgenic mice

Indexed keywords

ANTIBODY; CD4 ANTIGEN; CD45 ANTIGEN; CD69 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; HERMES ANTIGEN; HLA DR1 ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN; PADGEM PROTEIN; T LYMPHOCYTE RECEPTOR;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; AUTOIMMUNITY; CLONAL ANERGY; IMMUNOLOGICAL TOLERANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; MEMORY CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; CD4-POSITIVE T-LYMPHOCYTES; CLONAL ANERGY; CLONAL DELETION; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HEMAGGLUTININS, VIRAL; HLA-DR1 ANTIGEN; IMMUNOCONJUGATES; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; LEUKOCYTES, MONONUCLEAR; MICE; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; PEPTIDES; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, REGULATORY; TUBERCULIN; UP-REGULATION;

EID: 0035903329     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.6.719     Document Type: Article

References (77)

1. CTLA-4 regulates induction of anergy in vivo
2. B cells turn off virgin but not memory T cells
3. + T cells
4. Differential T cell receptor-mediated signaling in naive and memory CD4 T cells
5. Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells
6. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement
7. Induction of T cell anergy by low numbers of agonist ligands
8. + single positive cells with a class II major histocompatibility complex-restricted receptor
9. T cell memory
10. + cells of memory phenotype
11. Regulation of development and function of memory CD4 subsets
12. Qualitative changes accompany memory T cell generation: Faster, more effective responses at lower doses of antigen
13. An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen
14. Sodium dodecyl sulfate stability of HLA-DR1 complexes correlates with burial of hydrophobic residues in pocket 1
15. Stable peptide binding to MHC class II molecule is rapid and is determined by a receptive conformation shaped by prior association with low affinity peptides
16. HLA-DM recognizes the flexible conformation of major histocompatibility complex class II
17. + T cells proliferating in response to influenza A antigen
18. + T cells by HLA-DR1 oligomers is dependent on the T cell activation state
19. MHC class II function preserved by low-affinity peptide interactions preceding stable binding
20. Models of T cell anergy: Is there a common molecular mechanism?
21. + T cells
22. Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo
23. Adjuvant-guided type-1 and type-2 immunity: Infectious/noninfectious dichotomy defines the class of response
24. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
25. Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo
26. Anergic T cells as suppressor cells in vitro
27. Interleukin-2 programs mouse αβT lymphocytes for apoptosis
28. Peripheral selection of the T cell repertoire
29. + T cells express perturbed AP-1 and NF-κB transcription factors
30. Maintenance of human T cell anergy: Blocking of IL-2 gene transcription by activated Rap1
31. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
32. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
33. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
34. CTLA-4 can function as a negative regulator of T cell activation
35. Phenotypic analysis of CTLA-4 and CD28 expression during transient peptide-induced T cell activation in vivo
36. Antigen analog major histocompatibility complexes act as antagonists of the T cell receptor
37. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells
38. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
39. Three-dimensional segregation of supramolecular activation clusters in T cells
40. The immunological synapse: A molecular machine controlling T cell activation
41. The duration of antigenic stimulation determines the fate of naive and effector T cells
42. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo
43. Neonatal tolerance revisited: Turning on newborn T cells with dendritic cells
44. From naive to memory T cells
45. Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells
46. Linear differentiation of cytotoxic effectors into memory T lymphocytes
47. Modelling T-cell memory by genetic marking of memory T cells in vivo
48. Stability of naive and memory phenotypes on resting CD4 T cells in vivo
49. Differential role of CTLA-4 in regulation of resting memory versus naive CD4 T cell activation
50. Peripheral tolerance in T cell receptor-transgenic mice: Evidence for T cell anergy
51. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis
52. + T cell tolerance induction versus priming is independent of the rate and number of cell divisions
53. CTLA-4 ligation blocks CD28-dependent T cell activation
54. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
55. + T cells become nonresponsive (anergic) following activation in the presence of costinmlation
56. + immunoregulatory T cells that control autoimmune diabetes
57. + T cells
58. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
59. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
60. + regulatory cells that control intestinal inflammation
61. The role of CTLA-4 in regulating Th2 differentiation
62. Ablation of and induction of diabetes by virus infection in viral antigen transgenic mice
63. Coexpression of B7-1 and antigen blocks tolerance induction to antigen presented by resting B cells
64. Abundant empty class II MHC molecules on the surface of immature dendritic cells
65. The induction of tolerance by dendritic cells that have captured apoptotic cells
66. The stimulation of low-affinity, nontolerized clones by heteroclitic antigen analogues causes the breaking of tolerance established to an immunodominant T cell epitope
67. Is CTLA-4 a master switch for peripheral T cell tolerance?
68. Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tail
69. Molecular basis of T cell inactivation by CTLA-4
70. + T cells
71. Structural analysis of CTLA-4 function in vivo
72. Expression and function of CTLA-4 in Th1 and Th2 cells
73. Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152)
74. + T cells
75. Human pathogen subversion of antigen presentation
76. + T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes
77. + T cell-and IL-2-dependent mechanism