Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells

Blood

Volumn 96, Issue 5, 2000, Pages 1756-1763

  Moulding, Dale A ^a   Giles, Richard V ^a   Spiller, David G ^a   White, Michael R H ^a   Tidd, David M ^a   Edwards, Steven W ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MCL 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION;

EID: 0034283981     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.5.1756     Document Type: Article

References (34)

1. The Bcl-2 protein family: Arbiters of cell survival
2. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2
3. Mcl-1, a member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells
4. Bcl-2 and mcl-1 expression in Chinese hamster ovary cells inhibits intracellular acidification and apoptosis induced by staurosporine
5. Mcl-1, a Bcl-2 family member, delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions
6. Mcl-1 expression in human neutrophils: Regulation by cytokines and correlation with cell survival
7. Expression of the Bcl-2 homologue Mcl-1 correlates with survival of peripheral blood B lymphocytes
8. Atrial natriuretic peptide induces apoptosis in neonatal rat cardiac myocytes
9. The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2
10. Caspases: Enemies within
11. Conversion of Bcl-2 to a Bax-like death effector by caspases
12. The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interactions with CED-4
13. Expression of the antiapoptotic MCL1 gene product is regulated by a mitogen activated protein kinase-mediated pathway triggered through microtubule disruption and protein kinase C
14. The uptake kinetics of chimeric oligodeoxynucleotide analogues in human leukaemia MOLT-4 cells
15. Deprotection of methylphosphonate oligonucleotides using a novel one-pot procedure
16. Enhanced antisense effects resulting from an improved streptolysin-o protocol for oligodeoxynucleotide delivery into human leukaemia cells
17. Selecting optimal oligonucleotide composition for maximal antisense effect following streptolysin O-mediated delivery into human leukaemia cells
18. Single-step method of RNA isolation by acid guanidinium thiocyanatephenol-chloroform extraction
19. Regulation of neutrophil apoptosis by sodium butyrate
20. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
21. Improving the intracellular delivery and molecular efficacy of antisense oligonucleotides in chronic myeloid leukemia cells: A comparison of streptolysin-O permeabilization, electroporation, and lipophilic conjugation
22. Increased specificity for anti-sense oligodeoxynucleotide targeting of RNA cleavage by RNase H using chimeric methylphosphonodiester/phosphodiester structures
23. Optimization of antisense oligodeoxynucleotide structure for targeting bcr-abl mRNA
24. Interferon gamma drastically modifies the regulation of interleukin 1 genes by endotoxin in U937 cells
25. Apoptosis
26. Dissociation of phagocyte recognition of cells undergoing apoptosis from other features of the apoptotic program
27. Bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages
28. Cloning of a bcl-2 homologue by interaction with adenovirus E1b 19K
29. Induction of apoptosis by the Bcl-2 homologue Bak
30. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak
31. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channels VDAC
32. Biochemical and functional comparisons of Mcl-1 and Bcl-2 proteins: Evidence for a novel mechanism of regulating Bcl-2 family protein function
33. Mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signalling pathway and is one component of the GM-CSF viability response
34. Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse