TNF-α gene expression in macrophages: Regulation by NF-κB is independent of c-Jun or C/EBPβ

Journal of Immunology

Volumn 164, Issue 8, 2000, Pages 4277-4285

  Liu, Hongtao ^a   Sidiropoulos, Prodromos ^a   Song, Guobin ^a   Pagliari, Lisa J ^a   Birrer, Michael J ^b   Stein, Bernd ^c   Anrather, Josef ^d   Pope, Richard M ^a,e  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Signal Pharmaceuticals   (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PLASMID VECTOR; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ADENOVIRUS; ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MACROPHAGE; NONHUMAN; ONCOGENE C JUN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSCRIPTION REGULATION; VIRUS INFECTION;

EID: 0034655155     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.8.4277     Document Type: Article

References (43)

1. Vassalli, P. 1992. The pathophysiology of tumor necrosis factors. Annu. Rev. Immunol. 10:411.
2. Feldmann, M., F. M. Brennan, and R. N. Maini. 1996. Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14:397.
3. MacNaul, K. L., N. I. Hutchinson, J. N. Parson, E. K. Bayne, and M. J. Tocci. 1990. Analysis of IL-1 and TNF-α gene expression in human rheumatoid synoviocytes and normal monocytes by in situ hybridization. J. Immunol. 145:4154.
4. Economou, J. S., K. Rhoades, R. Essner, W. H. McBride, J. C. Gasson, and D. L. Morton. 1989. Genetic analysis of the human tumor necrosis factor α/cachectin promoter region in a macrophage cell line. J. Exp. Med. 170:321.
5. Pope, R. M., A. Leutz, and S. A. Ness. 1994. C/EBPβ regulation of the tumor necrosis factor α gene. J. Clin. Invest. 94:1449.
6. Wedel, A., G. Sulski, and H. W. L. Ziegler-Heitbrock. 1996. CCAAT/enhancer binding protein is involved in the expression of the tumor necrosis factor gene in human monocytes. Cytokine 8:335.
7. Yao, J., N. Mackman, T. S. Edgington, and S.-T. Fan. 1997. Lipopolysaccharide induction of the tumor necrosis factor-α promoter in human monocytic cells. J. Biol. Chem. 272:17795.
8. Udalova, I. A., J. C. Knight, V. Vidal, S. A. Nedospasov, and D. Kwiatkowski. 1998. Complex NF-κB interactions at the distal tumor necrosis factor promoter region in human monocytes. J. Biol. Chem. 273:21178.
9. Nakajima, T., S. Kinoshita, T. Sasagawa, K. Sasaki, M. Naruto, T. Kishimoto, and S. Akira. 1993. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc. Natl. Acad. Sci. USA 90:2207.
10. Trautwein, C., C. Caelles, P. van der Geer, T. Hunter, M. Karin, and M. Chojkier. 1993. Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain. Nature 364:544.
11. 2 production in lipopolysaccharide-stimulated monocytes. J. Immunol. 161:5681.
12. Nakano, H., M. Shindo, S. Sakon, S. Nishinaka, M. Mihara, H. Yagita, and K. Okumura. 1998. Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc. Natl. Acad. Sci. USA 95:3537.
13. Focy, A. D., S. L. Parry, L. M. Williams, M. Feldmann, B. M. J. Foxwell, and F. M. Brennan. 1998. Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-α: role of the p38 and p42/44 mitogen-activated protein kinases. J. Immunol. 160:920.
14. Baldwin, A. S. J. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649.
15. Bohuslav, J., V. V. Kravchenko, G. C. N. Parry, J. H. Erlich, S. Gerondakis, N. Mackman, and R. J. Ulevitch. 1998. Regulation of an essential innate immune response by the p50 subunit of NF-κB. J. Clin. Invest. 102:1645.
16. Oeth, P. A., P. G.C.N., C. Kunsch, P. Nantermet, C. A. Rosen, and N. Mackman. 1994. Lipopolysaccharide induction of tissue factor gene expression in monocytic cells is mediated by binding of c-Rel/p65 heterodimers to a κB-like site. Mol. Cell. Biol. 14:3772.
17. Stein, B., P. C. Cogswell, and A. S. Baldwin, Jr. 1993. Functional and physical associations between NF-κB and C/EBP family members: Rel domain-b-ZIP interaction. Mol. Cell. Biol. 13:3964.
18. LeClair, K. P., M. A. Blanar, and P. A. Sharp. 1992. The p50 subunit of NF-κB associates with the NF-IL6 transcription factor. Proc. Natl. Acad. Sci. USA 89: 8145.
19. Plevy, S. E., J. H. M. Gemberling, S. Hsu, A. J. Dorner, and S. T. Smale. 1997. Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol. Cell. Biol. 17:4572.
20. Kunsch, C., R. K. Lang, C. A. Rosen, and M. F. Shannon. 1994. Synergistic transcriptional activation of the IL-8 gene by TNFα-p65 (RelA) and NF-IL-6. J. Immunol. 153:153.
21. Matsusaka, T., K. Fujikawa, Y. Nishio, N. Makaida, K. Matsushima, T. Kishimoto, and S. Akira. 1993. Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines interleukin 6 and interleukin 8. Proc. Natl. Acad. Sci. USA 90:10193.
22. Zagariya, A., S. Mungre, R. Lovis, M. Birrer, S. Ness, B. Thimmapaya, and R. Pope. 1998. Tumor necrosis α gene regulation: enhancement of C/EBPβ-induced activation by c-Jun. Mol. Cell. Biol. 18:2815.
23. Tsai, E. Y., J. Jain, P. A. Pesavento, A. Rao, and A. E. Goldfeld. 1996. Tumor necrosis factor α gene regulation in activated T cells involves ATF-2/Jun and NF-ATp. Mol. Cell. Biol. 16:459.
24. Rhoades, K. L., S. H. Golub, and J. S. Economou. 1992. The regulation of the human tumor necrosis factor α promoter region in macrophage, T cell and B cell lines. J. Biol. Chem. 267:22102.
25. Stein, B., A. S. Baldwin, Jr., B. W. Ballard, W. C. Greene, P. Angel, and P. Herrlich. 1993. Cross-coupling of the NF-κB p65 and Fos/Jun transcription factors produces potential biological function. Mol. Cell. Biol. 12:3879.
26. Goldfeld, A. E., J. L. Strominger, and C. Doyle. 1991. Human tumor necrosis factor α gene regulation in phorbol ester stimulated T and B cell lines. J. Exp. Med. 174:73.
27. Baer, M., S. C. Williams, A. Dillner, R. C. Schwartz, and P. F. Johnson. 1998. Autocrine signals control CCAAT/enhancer binding protein β expression, localization, and activity in macrophages. Blood 92:4353.
28. LaCour, E. G., M. H. Grayson, C. F. Ware, and R. M. Pope. 1990. Enhanced cytotoxicity in the rheumatoid joint. Clin. Immunol. Immunopathol. 54:431.
29. Soares, M. P., A. Muniappan, E. Kaczmarek, K. Koziak, C. J. Wrighton, F. Steinhauslin, C. Ferran, H. Winkler, F. H. Bach, and J. Anrather. 1998. Adenovirus-mediated expression of a dominant negative mutant of p65/RelA inhibits proinflammatory gene expression in endothelial cells without sensitizing to apoptosis. J. Immunol. 161:4572.
30. Furtado, M. R., S. Subramanian, R. A. Bhat, D. M. Fowlkes, B. Safer, and B. Thimmappaya. 1989. Functional dissection of adenovirus VAI RNA. J. Virol. 63:3423.
31. Ghadge, G. D., S. Swaminathan, M. Katze, and B. Thimmapaya. 1991. Binding of the adenovirus VAI RNA to Interferon induced 68 kDa protein kinase correlates with function. Proc. Natl. Acad. Sci. USA 88:7140.
32. Kaspers, G. J., A. J. Veerman, R. Pieters, C. H. Van Zantwijk, L. A. Smets, E. R. Van Wering, and A. Van Der Does-Van Den Berg. 1997. In vitro cellular drug resistance and prognosis in newly diagnosed childhood acute lymphoblastic leukemia. Blood 90:2723.
33. Kamei, Y., L. Xu, T. Heinzel, J. Torchia, R. A. Heyman, D. W. Rose, G. a. C.K., and M. G. Rosenfeld. 1996. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85:403.
34. Perkins, N. D., L. K. Felzien, J. C. Betts, K. Leung, D. H. Beach, and G. J. Nabel. 1997. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science 275:523.
35. Foxwell, B., K. Browne, J. Bondeson, C. Clarke, R. DeMartin, F. Brennan, and M. Feldmann. 1998. Efficient adenoviral infection with IκBα reveals that macrophage tumor necrosis factor α production in rheumatoid arthritis is NF-κB dependent. Proc. Natl. Acad. Sci. USA 95:8211.
36. Baldwin, A. S., Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649.
37. Anrather, J., V. Csizmadia, C. Brostjan, M. P. Soares, F. H. Bach, and H. Winkler, 1997. Inhibition of bovine endothelial cell activation in vitro by regulated expression of a transdominant inhibitor of NF-κB. J. Clin. Invest. 99: 763.
38. Oeth, P., G. C. N. Parry, and N. Mackman. 1997. Regulation of the tissue factor gene in human monocytic cells. Arterioscler. Thromb. Vasc. Biol. 17:365.
39. Thomas, R. S., M. J. Tymms, L. H. McKinlay, M. F. Shannon, A. Seth, and I. Kola. 1997. ETSI, NF-κB and AP1 synergistically transactivate the human GM-CSF promoter. Oncogene 14:2845.
40. Trede, N. S., E. Castigli, R. S. Geha, and T. Chatila. 1993. Microbial superantigens induce NF-κB in the human monocytic cell line THP-1. J. Immunol. 150: 5604.
41. Kuprash, D. V., I. A. Udalova, R. L. Turetskay, D. Kwiatkowski, N. R. Rice, and S. A. Nedospasov. 1999. Similarities and differences between human and murine TNF promoters in their response to lipopolysaccharide. J. Immunol. 162:4045.
42. Baeuerle, P. A. 1991. The inducible transcription factor NF-κB: regulation by distinct protein subunits. Biochim. Biophys. Acta 1072:63.
43. Baer, M., A. Dilliner, R. C. Schwartz, C. Sedon, S. Nedospasov, and P. F. Johnson. 1998. Tumor necrosis factor α transcripition in macrophages is attenuated by an autocrine factor that preferentially induces NF-κB p50. Mol. Cell Biol. 18:5678.