Protein-protein interfaces: Mimics and inhibitors

Current Opinion in Chemical Biology

Volumn 5, Issue 6, 2001, Pages 654-659

  Cochran, Andrea G ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CYCLODEXTRIN; PEPTIDE; PROTEIN; PROTEIN APP; PROTEIN BCL 2; PROTEIN G; PROTEIN INHIBITOR; PROTEIN MDM2; PROTEIN P53; TRANSCRIPTION FACTOR GCN4; UNCLASSIFIED DRUG;

ALPHA HELIX; APOPTOSIS; CANCER; COMPLEX FORMATION; MOLECULAR MIMICRY; MOLECULAR RECOGNITION; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; THERMODYNAMICS;

EID: 0035630691     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(01)00262-9     Document Type: Review

References (43)

1. Antagonists of protein-protein interactions
2. Peptide and protein recognition by designed molecules
3. Forming stable helical peptides using natural and artificial amino acids
4. An all-hydrocarbon crosslinking system for enhancing the helicity and metabolic stability of peptides
5. Structure-function analysis of a phage display-derived peptide that binds to insulin-like growth factor binding protein 1
6. Toward proteomimetics: Terphenyl derivatives as structural and functional mimics of extended regions of an α-helix
7. Phage display in pharmaceutical biotechnology
8. Highly specific DNA recognition by a designed miniature protein
9. Concerted evolution of structure and function in a miniature protein
10. X-ray analysis (1.4 Å resolution) of avian pancreatic polypeptide: Small globular protein hormone
11. Minimalist, alanine-based, helical protein dimers bind to specific DNA sites
12. A minimal peptide scaffold for β-turn display: Optimizing a strand position in disulfide-cyclized β-hairpins
13. Tryptophan zippers: Stable monomeric β-hairpins
14. Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice
15. Design of growth factor antagonists with antiangiogenic and antitumor properties
16. Selective disruption of protein aggregation by cyclodextrin dimers
17. Biochemical properties and biological effects of p53
18. Structure of the MDM2 oncoprotein bound to the p53 tumor supressor transactivation domain
19. Isolation and structure elucidation of chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp
20. Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53
21. Apoptosis signaling
22. L-Bak peptide complex: Recognition between regulators of apoptosis
23. Regulation of apoptosis in a cell-free system
24. Bcl-2 family members as targets for anticancer drug design
25. Death by design: The big debut of small molecules
26. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
27. L
28. Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3
29. Tetrocarcin A inhibits mitochondrial functions of Bcl-2 and supresses its antiapoptotic activity
30. Exploiting the basis of proline recognition by SH3 and WW domains: Design of N-substituted inhibitors
31. Improving SH3 domain ligand selectivity using a non-natural scaffold
32. PDZ domains: Fundamental building blocks in the organization of protein complexes at the plasma membrane
33. Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex
34. Analysis of PDZ domain-ligand interactions using carboxyl-terminal phage display
35. Screening for receptor ligands using large libraries of peptides linked to the C terminus of lac repressor
36. A structural view of mitochondria-mediated apoptosis
37. Structural basis of binding of Smac/DIABLO to the XIAP BIR3 domain
38. Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias
39. Combinatorial target-guided ligand assembly: Identification of potent subtype-selective c-Src inhibitors
40. Chemical ligands, genomics and drug discovery
41. Site-directed ligand discovery
42. Designing small-molecule switches for protein-protein interactions
43. Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels