Designing small-molecule switches for protein-protein interactions

Science

Volumn 288, Issue 5473, 2000, Pages 2042-2045

  Guo, Zhihong ^a   Zhou, Demin ^a   Schultz, Peter G ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE; INDOLE DERIVATIVE;

ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CRYSTAL STRUCTURE; GENE MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL DIVISION; CELL LINE; HUMAN GROWTH HORMONE; IMIDAZOLES; JANUS KINASE 2; LIGANDS; MICE; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; RECEPTORS, SOMATOTROPIN; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0034674624     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.288.5473.2042     Document Type: Article

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31. The authors acknowledge funding from the Norvartis Research Foundation.