Leptin directly induces the secretion of interleukin 1 receptor antagonist in human monocytes

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 2, 2001, Pages 783-791

  Gabay, Cem ^a   Dreyer, Magali G ^a   Pellegrinelli, Nathalie ^a   Chicheportiche, Rachel ^a   Meier, Christoph A ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 12; INTERLEUKIN 6; LEPTIN; LEPTIN RECEPTOR; LIPOPOLYSACCHARIDE; MESSENGER RNA; STAT PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ANIMAL EXPERIMENT; APPETITE; ARTICLE; CELL FUNCTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNE FUNCTION TEST; IMMUNOMODULATION; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TH2 CELL;

3T3 CELLS; ANIMALS; CELL DIFFERENTIATION; CELL LINE; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; KINETICS; LEPTIN; MICE; MONOCYTES; POLYMYXIN B; PROMOTER REGIONS (GENETICS); RECEPTORS, INTERLEUKIN-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIALOGLYCOPROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSFECTION;

ANIMALIA;

EID: 0035095953     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.86.2.783     Document Type: Article

References (35)

1. Weight-reducing effects of the plasma protein encoded by the obese gene
2. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells
3. Direct effects of leptin on brown and white adipose tissue
4. Direct intraovarian effects of leptin: Impairment of the synergistic action of insulin-like growth factor-I on follicle-stimulating hormone-dependent estradiol-17β production by rat ovarian granulosa cells
5. Leptin receptors expressed on pancreatic beta-cells
6. Leptin in the regulation of immunity, inflammation, and hematopoiesis
7. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
8. Leptin regulates proinflammatory immune responses
9. Leptin deficiency enhances sensitivity to endotoxin-induced lethality
10. Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor
11. Human leptin stimulates proliferation and activation of human circulating monocytes
12. A urine inhibitor of interleukin 1 activity that blocks ligand binding
13. Interleukin-1 receptor antagonist: Role in biology
14. Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice
15. Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene
16. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice
17. Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis
18. Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation
19. Interleukin-4 (IL-4) and IL-13 enhance the effect of IL-1β on production of IL-1 receptor antagonist by human primary hepatocytes and hepatoma HepG2 cells: Differential effect on C-reactive protein production
20. Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor α by phosphorylation of a ligand-independent trans-activating domain
21. Defective STAT signaling by the leptin receptor in diabetic mice
22. Intracellular IL-1 receptor antagonist promoter: Cell type-specific and inducible regulatory regions
23. The human intracellular interleukin 1 receptor antagonist promoter appropriately regulates gene expression in keratinocytes and gastrointestinal epithelial cells in vivo
24. Characterization of a low molecular weight isoform of IL-1 receptor antagonist
25. Leptin actions on food intake and body temperature are mediated by IL-1
26. Mouse IL-1 receptor antagonist isoforms: Complementary DNA cloning and protein expression of intracellular isoform and tissue distribution of secreted and intracellular IL-1 receptor antagonist in vivo
27. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
28. Acute-phase proteins and other systemic responses to inflammation
29. Plasma leptin levels are increased in survivors of acute sepsis: Associated loss of diurnal rhythm, in cortisol and leptin secretion
30. Leptin and interleukin-6 in sepsis
31. The effects of interleukin-10 on interleukin-1 receptor antagonist and interleukin-1 β production in human monocytes and neutrophils
32. Interleukin-13 (IL-13) induces IL-1 receptor antagonist gene expression and protein synthesis in peripheral blood mononuclear cells: Inhibition by an IL-4 mutant protein
33. Coordinated antiinflammatory effects of interleukin 4: Interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist
34. Balance of IL-1 receptor antagonist/IL-1 β in rheumatoid synovium and its regulation by IL-4 and IL-10
35. Activation of downstream signals by the long form of the leptin receptor