Reduced leptin levels in starvation increase susceptibility to endtoxic shock

American Journal of Pathology

Volumn 156, Issue 5, 2000, Pages 1781-1787

  Faggioni, R ^a   Moser, A ^a   Feingold, K R ^a   Grunfeld, C ^a  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; INFECTION RESISTANCE; INFECTION RISK; LETHALITY; MALNUTRITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPTIC SHOCK; STARVATION;

EID: 0033847637     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65049-3     Document Type: Article

References (40)

1. Leptin and the regulation of body weight in mammals
2. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
3. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
4. Role of leptin in the neuroendocrine response to fasting
5. Seminars in medicine of the Beth Israel Deaconess Medical Center. Neuroendocrine responses to starvation and weight loss
6. A longitudinal hormonal profile of the genetically obese mouse
7. Nutrition, immunity and infection: From basic knowledge of dietary manipulation of immune responses to practical application of ameliorating Suffering and improving survival
8. Cell-mediated immunity in nutritional imbalance
9. Cell-mediated immunity in anorexia nervosa
10. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
11. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice
12. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters
13. Multiple cytokines and acute inflammation raise mouse leptin levels: Potential role in inflammatory anorexia
14. IL-1β mediates leptin induction during inflammation
15. Identification and expression cloning of a leptin receptor OB-R
16. Abnormal splicing of the leptin receptor in diabetic mice
17. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
18. Crystal structure of the obese protein leptin-E100
19. Leptin deficiency enhances sensitivity to endotoxin-induced lethality
20. Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor
21. Immune-neuro-endocrine interactions: Facts and hypotheses
22. Effects of protein calorie malnutrition on tuberculosis in mice
23. Cytokines as mediators in the pathogenesis of septic shock
24. Leptin causes body weight loss in the absence of in vivo activities typical of cytokines of the IL-6 family
25. Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxic role of tumor necrosis factor alpha and IL-18
26. Prevention of lymphocyte cell death n sepsis improves survival in mice
27. Role of the hypothalamus-pituitary-adrenal axis in the regulation of TNF production in mice Effect of stress and inhibition of endogenous glucocorticoids
28. Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function
29. Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress
30. A regulatory loop between the hypothalamo-pituitary-adrenal (HPA) axis and circulating leptin: A physiologica role of ACTH
31. Anti-inflammatory actions of the neuroimmuno-modulator alpha-MSH
32. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and in ob/ob and db/db mice, but is stimulated by leptin
33. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
34. Melanocortin receptors in leptin effects
35. Recombinant IL-1 receptor antagonist protects against TNF-induced ethality in mice
36. Leptin actions on food intake and body temperature are mediated by IL-1
37. A role for leptin and its cognate receptor in hematopoiesis
38. Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction
39. Leptin stimulates the proliferation of murine myelocytic and primitive hematopoietic progenitor cells
40. Early onset of reproductive function in normal female mice treated with leptin