메뉴 건너뛰기




Volumn 274, Issue 6 43-6, 1998, Pages

Leptin produces anorexia and weight loss without inducing an acute phase response or protein wasting

Author keywords

Cachexia; Liver; Mouse; Tumor necrosis factor

Indexed keywords

LEPTIN;

EID: 0031778290     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.274.6.r1518     Document Type: Article
Times cited : (25)

References (46)
  • 1
    • 0030919919 scopus 로고    scopus 로고
    • Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: Leptin inhibits cortisol release directly
    • Bornstein, S. R., K. Uhlmann, A. Haidan, M. EhrhartBornstein, and W. A. Scherbaum. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: leptin inhibits cortisol release directly. Diabetes 46: 1235-1238, 1997.
    • (1997) Diabetes , vol.46 , pp. 1235-1238
    • Bornstein, S.R.1    Uhlmann, K.2    Haidan, A.3    Ehrhartbornstein, M.4    Scherbaum, W.A.5
  • 2
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • Chehab, F. F., M. E. Lim, and R. Lu. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat. Genet. 12: 318-320, 1996.
    • (1996) Nat. Genet. , vol.12 , pp. 318-320
    • Chehab, F.F.1    Lim, M.E.2    Lu, R.3
  • 4
    • 0029860791 scopus 로고    scopus 로고
    • Modulation of insulin activities by leptin
    • Cohen, B., D. Novick, and M. Rubinstein. Modulation of insulin activities by leptin. Science 274: 1185-1188, 1996.
    • (1996) Science , vol.274 , pp. 1185-1188
    • Cohen, B.1    Novick, D.2    Rubinstein, M.3
  • 6
    • 0030965884 scopus 로고    scopus 로고
    • Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion
    • Emilsson, V., Y. L. Liu, M. A. Cawthorne, N. M. Morton, and M. Davenport. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 46: 313-316, 1997.
    • (1997) Diabetes , vol.46 , pp. 313-316
    • Emilsson, V.1    Liu, Y.L.2    Cawthorne, M.A.3    Morton, N.M.4    Davenport, M.5
  • 7
    • 0029818204 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor is catabolic and shares with IL-6 the capacity to induce an acute phase response
    • Regulatory Integrative Comp. Physiol. 40
    • Espat, N. J., T. Auffenberg, J. J. Rosenberg, M. Rogy, D. Martin, C. H. Fang, P. O. Hasseigren, E. M. Copeland, and L. L. Moldawer. Ciliary neurotrophic factor is catabolic and shares with IL-6 the capacity to induce an acute phase response. Am. J. Physiol. 271 (Regulatory Integrative Comp. Physiol. 40): R185-R190, 1996.
    • (1996) Am. J. Physiol. , vol.271
    • Espat, N.J.1    Auffenberg, T.2    Rosenberg, J.J.3    Rogy, M.4    Martin, D.5    Fang, C.H.6    Hasseigren, P.O.7    Copeland, E.M.8    Moldawer, L.L.9
  • 8
    • 0031010408 scopus 로고    scopus 로고
    • Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
    • Fei, H., H. J. Okano, C. Li, G. H. Lee, C. Zhao, R. Darnell, and J. M. Friedman. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc. Natl.Acad. Sci. USA 94: 7001-7005, 1997.
    • (1997) Proc. Natl.Acad. Sci. USA , vol.94 , pp. 7001-7005
    • Fei, H.1    Okano, H.J.2    Li, C.3    Lee, G.H.4    Zhao, C.5    Darnell, R.6    Friedman, J.M.7
  • 11
    • 0026022698 scopus 로고
    • Role of endogenous tumor necrosis factor alpha and interleukin 1 for experimental tumor growth and the development of cancer cachexia
    • Gelin, J., L. L. Moldawer, C. Lonnroth, B. Sherry, R. Chizzonite, and K. Lundholm. Role of endogenous tumor necrosis factor alpha and interleukin 1 for experimental tumor growth and the development of cancer cachexia. Cancer Res. 51: 415-421, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 415-421
    • Gelin, J.1    Moldawer, L.L.2    Lonnroth, C.3    Sherry, B.4    Chizzonite, R.5    Lundholm, K.6
  • 16
    • 0029976373 scopus 로고    scopus 로고
    • Early and late stimulation of ob mRNA expression in meal-fed and overfed rats
    • Harris, R. B., T. G. Ramsay, S. R. Smith, and R. C. Bruch. Early and late stimulation of ob mRNA expression in meal-fed and overfed rats. J. Clin. Invest. 97: 2020-2026, 1996. .
    • (1996) J. Clin. Invest. , vol.97 , pp. 2020-2026
    • Harris, R.B.1    Ramsay, T.G.2    Smith, S.R.3    Bruch, R.C.4
  • 17
    • 0021843147 scopus 로고
    • Isolation of alpha 1-acid glycoprotein from human plasma using high-performance liquid chromatography
    • Hellerstein, M. K., V. Sasak, J. Ordovas, and H. N. Munro. Isolation of alpha 1-acid glycoprotein from human plasma using high-performance liquid chromatography. Anal. Biochem. 146: 366-371, 1985.
    • (1985) Anal. Biochem. , vol.146 , pp. 366-371
    • Hellerstein, M.K.1    Sasak, V.2    Ordovas, J.3    Munro, H.N.4
  • 21
    • 0028939345 scopus 로고
    • Finding an obesity gene-a tale of mice and man
    • Lindpaintner, K. Finding an obesity gene-a tale of mice and man. N. Engl. J. Med. 332: 679-680, 1995.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 679-680
    • Lindpaintner, K.1
  • 22
    • 0031567614 scopus 로고    scopus 로고
    • Leptin inhibits glycogen synthesis in the isolated soleus muscle of obese
    • Liu, Y. L., V. Emilsson, and M. A. Cawthorne. Leptin inhibits glycogen synthesis in the isolated soleus muscle of obese (ob/ob) mice. FEBS Lett. 41: 351-355, 1997.
    • (1997) (Ob/ob) Mice. FEBS Lett. , vol.41 , pp. 351-355
    • Liu, Y.L.1    Emilsson, V.2    Cawthorne, M.A.3
  • 23
    • 0025222461 scopus 로고
    • Tumor necrosis factor-alpha and interleukin-1 alpha production in cachectic, tumor-hearing mice
    • Lonnroth, C., L. L. Moldawer, J. Gelin, L. Kindblom, B. Sherry, and K. Lundholm. Tumor necrosis factor-alpha and interleukin-1 alpha production in cachectic, tumor-hearing mice. Int. J. Cancer 46: 889-896, 1990.
    • (1990) Int. J. Cancer , vol.46 , pp. 889-896
    • Lonnroth, C.1    Moldawer, L.L.2    Gelin, J.3    Kindblom, L.4    Sherry, B.5    Lundholm, K.6
  • 24
    • 0029078449 scopus 로고
    • Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes
    • MacDougald, O. A., C. S. Hwang, H. Fan, and M. D. Lane. Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc. Natl. Acad. Sci. USA 92: 9034-9037, 1995.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9034-9037
    • MacDougald, O.A.1    Hwang, C.S.2    Fan, H.3    Lane, M.D.4
  • 27
    • 0023879726 scopus 로고
    • Regulation of food intake and hepatic protein synthesis by recombinant-derived cytokines
    • Gastrointest. Liver Physiol. 17
    • Moldawer, L. L., C. Andersson, J. Gelin, and K. G. Lundholm. Regulation of food intake and hepatic protein synthesis by recombinant-derived cytokines. Am. J. Physiol. 254 (Gastrointest. Liver Physiol. 17): G450-G456, 1988.
    • (1988) Am. J. Physiol. , vol.254
    • Moldawer, L.L.1    Andersson, C.2    Gelin, J.3    Lundholm, K.G.4
  • 28
    • 0020534745 scopus 로고
    • The contribution of phenylalanine to tyrosine metabolism in vivo. Studies in the post-absorptive and phenylalanine-loaded rat
    • Moldawer, L. L., I. Kawamura, B. R. Bistrian, and G. L. Blackburn. The contribution of phenylalanine to tyrosine metabolism in vivo. Studies in the post-absorptive and phenylalanine-loaded rat. Biochem. J. 210: 811-817, 1983.
    • (1983) Biochem. J. , vol.210 , pp. 811-817
    • Moldawer, L.L.1    Kawamura, I.2    Bistrian, B.R.3    Blackburn, G.L.4
  • 30
    • 0040381066 scopus 로고    scopus 로고
    • Leptin impairs metabolic actions of insulin in isolated rat adipocytes
    • Muller, G., J. Ertl, M. Gerl, and G. Preibisch. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J. Biol. Chem. 272: 10585-10593, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 10585-10593
    • Muller, G.1    Ertl, J.2    Gerl, M.3    Preibisch, G.4
  • 32
    • 0028972884 scopus 로고
    • Dexamethasone regulates obese expression in isolated rat adipocytes
    • Murakami, T., M. lida, and K. Shima. Dexamethasone regulates obese expression in isolated rat adipocytes. Biochem. Biophys. Res. Commun. 214: 1260-1267, 1995.
    • (1995) Biochem. Biophys. Res. Commun. , vol.214 , pp. 1260-1267
    • Murakami, T.1    Lida, M.2    Shima, K.3
  • 37
    • 0029157428 scopus 로고
    • Transient increase in obese gene expression after food intake or insulin administration
    • Saladin, R., P. De Vos, M, Guerre Millo, A. Leturque, J. Girard, B. Staels, and J. Auwerx. Transient increase in obese gene expression after food intake or insulin administration. Nature 377: 527-529, 1995.
    • (1995) Nature , vol.377 , pp. 527-529
    • Saladin, R.1    De Vos, P.2    Guerre Millo, M.3    Leturque, A.4    Girard, J.5    Staels, B.6    Auwerx, J.7
  • 40
    • 0026689535 scopus 로고
    • Evidence for -the involvement of interleukin 6 in experimental cancer cachexia
    • Strassmann, G., M. Fong, J. S. Kenney, and C. O. Jacob. Evidence for -the involvement of interleukin 6 in experimental cancer cachexia. J. Clin. Invest. 89: 1681-1684, 1992.
    • (1992) J. Clin. Invest. , vol.89 , pp. 1681-1684
    • Strassmann, G.1    Fong, M.2    Kenney, J.S.3    Jacob, C.O.4
  • 43
    • 0029166158 scopus 로고
    • Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob/ob) mice
    • Trayhurn, P., M. E. Thomas, J. S. Duncan, and D. V. Rayner. Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob/ob) mice. FEBS Lett. 368: 488-490, 1995.
    • (1995) FEBS Lett. , vol.368 , pp. 488-490
    • Trayhurn, P.1    Thomas, M.E.2    Duncan, J.S.3    Rayner, D.V.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.