Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair

Journal of Clinical Investigation

Volumn 106, Issue 4, 2000, Pages 501-509

  Frank, Stefan ^a   Stallmeyer, Birgit ^a   Kämpfer, Heiko ^a   Kolb, Nicole ^a   Pfeilschifter, Josef ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN RECEPTOR; RECOMBINANT LEPTIN; STAT3 PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; EPITHELIZATION; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; WOUND HEALING IMPAIRMENT;

EID: 0033862589     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI9148     Document Type: Article

References (42)

1. Zhang, Y., et al. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:425-432.
2. Masuzaki, H., et al. 1995. Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue. Diabetes. 44:855-858.
3. Halaas, J.L., et al. 1995. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 269:543-546.
4. Vaisse, C., et al. 1996. Leptin activation of STAT3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat. Genet. 14:95-97.
5. Ghilardi, N., et al. 1996. Defective STAT signaling by the leptin receptor in diabetic mice. Proc. Natl. Acad. Sci. USA. 93:6231-6235.
6. Fei, H., et al. 1997. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc. Natl. Acad. Sci. USA. 94:7001-7005.
7. Lollmann, B., Gruninger, S., Stricker-Krongrad, A., and Chiesi, M. 1997. Detection and quantification of the leptin receptor splice variants Ob-Ra, b, and e in different mouse tissues. Biochem. Biophys. Res. Commun. 238:648-652.
8. Hoggard, N., et al. 1997. Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization. Biochem. Biophys. Res. Commun. 232:383-387.
9. Chehab, F.F., Lim, M.E., and Lu, R. 1996. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat. Genet. 12:318-320.
10. Chehab, F.F., Mounzih, K., Lu, R., and Lim, M.E. 1997. Early onset of reproductive function in normal female mice treated with leptin. Science. 275:88-90.
11. Bouloumie, A., Drexler, H.C., Lafontan, M., and Busse, R. 1998. Leptin, the product or Ob gene, promotes angiogenesis. Circ. Res. 83:1059-1066.
12. Santos-Alvarez, J., Goberna, R., and Sanchez-Margaler, V. 1999. Human leptin stimulates proliferation and activation of human circulating monocytes. Cell. Immunol. 194:6-11.
13. Tsuchiya, T., Shimizu, H., Horie, T., and Mori, M. 1999. Expression of leptin receptor in lung: leptin as a growth factor. Eur. J. Pharmacol. 365:273-279.
14. Tanabe, K., Okuya, S., Tanizawa, Y., Matsutani, A., and Oka, Y. 1997. Leptin induces proliferation of pancreatic beta cell line MIN6 through activation of mitogen-activated protein kinase. Biochem. Biophys. Res. Commun. 241:765-768.
15. Islam, M.S., Morton, N.M. Hansson, A., and Emilsson, V. 1997. Rat insulinoma-derived pancreatic beta-cells express a functional leptin receptor that mediates a proliferative response. Biochem. Biophys. Res. Commun. 238:851-855.
16. Konpleva, M., et al. 1999. Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: proliferative and anti-apoptotic activities. Blood. 93:1668-1676.
17. Sierra-Honigmann, M.R., et al. 1998. Biological action of leptin as an angiogenic factor. Science. 281:1683-1686.
18. Martin, P. 1997. Wound healing: aiming for perfect skin regeneration. Science. 276:75-81.
19. Nanney, L.B. 1990. Epidermal and dermal effects of epidermal growth factor during wound repair. J. Invest. Dermatol. 94:624-629.
20. Marchese, C., et al. 1995. Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin. J. Exp. Med. 182:1369-1376.
21. Frank, S., Stallmeyer, B., Kämpfer, H., Kolb, N., and Pfeilschifter, J. 1999. Nitric oxide triggers enhanced induction of vascular endothelial growth factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair. FASEB J. 13:2002-2014.
22. Chomczynski, P., and Sacchi, N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
23. Werner, S., et al. 1992. Large induction of keratinocyte growth factor expression in the dermis during wound healing. Proc. Natl. Acad. Sci. USA. 89:6896-6900.
24. Tartaglia, L.A., et al. 1995. Identification and expression cloning of a leptin receptor, OB-R. Cell. 83:1263-1271.
25. Boukamp, P., et al. 1988. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol. 106:761-771.
26. Schreiber, E., Matthias, P., Müller, M.M., and Schaffner, W. 1989. Rapid detection of octamer binding proteins with "mini-extracts" prepared from a small number of cells. Nucl. Acids Res. 17:6419.
27. Gerdes, J., et al. 1984. Cell cycle analysis of a cell proliferation associated human nuclear antigen defined by the monoclonal antibody Ki67. J. Immunol. 133:1710-1715.
28. Cavey, M.T., Cavey, D., Shroot, B., Reichert, U., and Gazith, J. 1986. Receptor-linked adenylate cyclase in the membranes of cultured human epidermal keratinocytes. Arch. Dermatol. Res. 278:293-297.
29. Takahashi, H., Tamura, T., Tsutsui, M., and Iizuka, H. 1990. Adenylate cyclase in fetal rat keratinizing epidermal cells (FRSK cells) and SV40-transformed human keratinocytes. J. Dermatol. 17:457-464.
30. Darnell, J.E., Jr. 1997. STATS and gene regulation. Science. 277:1630-1635.
31. Klingbeil, C.K., Cesar, L.B., and Fiddes, J C. 1991. Basic fibroblast growth factor accelerates tissue repair in models of impaired wound healing. Prog. Clin. Biol. Res. 365:443-458.
32. Coleman, D.I., 1982. Diabetes: obesity syndromes in mice. Diabetes. 31:1-6.
33. Brown, G.L., et al. 1989. Enhancement of wound healing by topical treatment with epidermal growth factor. N. Engl. J. Med. 321:76-79.
34. Schultz, G.S., et al. 1987. Epithelial wound healing enhanced by transforming growth factor-alpha and vaccinia growth factor. Science. 235:350-352.
35. Werner, S., et al. 1994. The function of KGF in morphogenesis of epithelium and reepithelialization of wounds. Science. 266:819-822.
36. Wenczak, B.A., Lynch, J.B., and Nanney, L.B. 1992. Epidermal growth factor receptor distribution in burn wounds. Implications for growth factor-mediated repair. J. Clin. Invest. 90:2392-2401.
37. Mansbridge, J.N., and Knapp, A.M. 1987. Changes in keratinocyte maturation during wound healing. J. Invest. Dermatol. 89:253-263.
38. Stoscheck, C.M., Nanney, L.B., and King, L.E. 1992. Quantitative determination of EGF-R during epidermal wound healing. J. Invest. Dermatol. 99:645-649.
39. Tsuboi, R., Shi, C.M., Ritkin, D.B., and Ogawa, H. 1992. A wound healing model using healing-impaired diabetic mice. J. Dermatol. 19:673-675.
40. Gainsford, T., et al. 1996. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc. Natl. Acad. Sci. USA. 93:14564-14568.
41. Takahashi, Y., et al. 1997. Leptin induces mitogen-activated protein kinase-dependent proliferation of C3H10T1/2 cells. J. Biol. Chem. 272:12897-12900.
42. Sano, S., et al. 1999. Keratinocyte-specific ablation of STAT3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J. 18:4657-4668.