Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function

Journal of Biological Chemistry

Volumn 274, Issue 14, 1999, Pages 9617-9626

  Lee, Benhur ^a,b   Sharron, Matthew ^a   Blanpain, Cedric ^c   Doranz, Benjamin J ^a   Vakili, Jalal ^c   Setoh, Pui ^d   Berg, Ellen ^d   Liu, Gao ^d   Guy, H Robert ^e   Durell, Stewart R ^e   Parmentier, Marc ^c   Chang, Chung Nan ^d   Price, Ken ^f   Tsang, Monica ^f   Doms, Robert W ^a,g  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b WISTAR INSTITUTE   (United States)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^d PDL Inc   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

^f R and D Systems Inc   (United States)

^g HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CCR5; GLUTAMIC ACID; GLYCOPROTEIN GP 120; LYSINE; MACROPHAGE INFLAMMATORY PROTEIN; MONOCLONAL ANTIBODY; PHENYLALANINE; RANTES; TYROSINE; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; EPITOPE MAPPING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MEMBRANE FUSION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; VIRUS INHIBITION;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; CELL LINE; CHEMOKINES; COMPUTER SIMULATION; EPITOPE MAPPING; FLOW CYTOMETRY; GENE PRODUCTS, ENV; HIV-1; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0033515588     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.14.9617     Document Type: Article

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