Controlling allergic inflammation by signaling regulation of eosinophils

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 56, Issue 3, 2001, Pages 204-214

  Koenderman, L ^a   Coffer, P J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3; INTERLEUKIN 5;

ALLERGIC REACTION; EOSINOPHIL; HUMAN; IMMUNOREGULATION; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; REVIEW; SIGNAL TRANSDUCTION;

EOSINOPHILS; HUMANS; HYPERSENSITIVITY; INFLAMMATION; SIGNAL TRANSDUCTION;

EID: 0035092759     PISSN: 01054538     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1398-9995.2001.056003204.x     Document Type: Review

References (144)

1. Mechanisms of eosinophil-associated inflammation
2. Pulmonary immune cells in health and disease: The eosinophil leucocyte. I
3. Changes in bone marrow inflammatory cell progenitors after inhaled allergen in asthmatic subjects
4. Comparative study of simultaneous blood and nasal secretion eosinophilia in children with allergic diseases
5. Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions
6. Leukocytes and mediators in bronchoalveolar lavage during allergen-induced late-phase asthmatic reactions
7. The airway inflammatory response in allergic asthma and its relationship to clinical disease
8. In vivo priming of platelet-activating factor-induced eosinophil chemotaxis in allergic asthmatic individuals
9. Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects
10. IL-4 controls the selective endothelium-driven transmigration of eosinophils from allergic individuals
11. Human eosinophil-granule major basic protein and synthetic polycations induce airway hyperresponsiveness in vivo dependent on bradykinin generation
12. Episodic angioedema associated with eosinophilia
13. Inflammation and cell-cell interactions in airway hyperresponsiveness
14. Eosinophil-associated TGF-beta 1 mRNA expression and airways fibrosis in bronchial asthma
15. Expression of Th1 and Th2 immunoregulatory cytokines by human eosinophils
16. Eosinophils and eosinophil-associated cytokines in allergic inflammation
17. Eokines: Synthesis, storage and release from human eosinophils
18. Regulation of the function of eosinophils and basophils
19. Eosinophil priming by cytokines: From cellular signal to in vivo modulation
20. Intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and regulated on activation normal T cell expressed and secreted are expressed by human breast carcinoma cells and support eosinophil adhesion and activation
21. Stimulation of the beta(2) integrin, alpha(M)beta(2), triggers tyrosine phosphorylation and cellular degranulation on human eosinophils
22. Ecalectin/galectin-9, a novel eosinophil chemoattractant: Its function and production
23. The functionality of HLA-G is emerging
24. Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily
25. Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils
26. Signal transduction by the GM-CSF, IL-3 and IL-5 receptors
27. Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family
28. Signaling domains of the beta c chain of the GM-CSF/IL-3/IL-5 receptor
29. Characterization of critical residues in the cytoplasmic domain of the human interleukin-5 receptor alpha chain required for growth signal transduction
30. A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction
31. A model for assembly and activation of the GM-CSF, IL-3 and IL-5 receptors: Insights from activated mutants of the common beta subunit
32. The mechanism of IL-5 signal transduction
33. Advances in understanding the postreceptor mechanisms of action of GM-CSF, G-CSF, and Steel factor
34. JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor and its activation requires the membrane-proximal region
35. Heterodimerization of the alpha and beta chains of the interleukin-3 (IL-3) receptor is necessary and sufficient for IL-3-induced mitogenesis
36. Mechanism of activation of the GM-CSF, IL-3, and IL-5 family of receptors
37. Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils
38. The intracellular signal transduction mechanism of interleukin 5 in eosinophils: The involvement of lyn tyrosine kinase and the Ras-Raf-1-MEK-microtubule-associated protein kinase pathway
39. Evidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor
40. Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/SoS and Grb2/p140 complexes to the beta receptor subunit
41. Regulation and function of protein kinase B and MAP kinase activation by the IL-5/GM-CSF/IL-3 receptor
42. Multiple tyrosine residues in the intracellular domain of the common beta subunit of the interleukin 5 receptor are involved in activation of STAT5
43. Binding of src-like kinases to the beta-subunit of the interleukin-3 receptor
44. Granulocyte macrophagecolony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells
45. Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation
46. Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
47. Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1 alpha
48. The activation of the Jak-STAT 1 signaling pathway by IL-5 in eosinophils
49. Activation of a functionally distinct 80-kDa STAT5 isoform by IL-5 and GM-CSF in human eosinophils and neutrophils
50. Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival
51. Association of RACK 1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor
52. Interleukin 5 regulates the isoform expression of its own receptor alpha-subunit
53. G proteins: Critical control points for transmembrane signals
54. Molecular analysis of CCR-3 events in eosinophilic cells
55. Signal transduction in activation of human eosinophils: G protein-dependent and -independent pathways
56. An improved method for the isolation of eosinophilic granulocytes from peripheral blood of normal individuals
57. 2+ and protein kinase C via distinct mechanisms
58. 2+, protein kinase C and phospholipases C and D
59. Priming of the respiratory burst in human eosinophils is accompanied by changes in signal transduction
60. Eosinophil leukocyte degranulation in response to serum-opsonized beads: C5a and platelet-activating factor enhance ECP release, with roles for protein kinases A and C
61. A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits
62. Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation
63. Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction
64. Function of PI3Kgamma in thymocyte development. T cell activation, and neutrophil migration
65. Platelet-activating factor stimulates a rapid accumulation of inositol (1, 4, 5)trisphosphate in guinea pig eosinophils: Relationship to calcium mobilization and degranulation
66. Shape changes, exocytosis, and cytosolic free calcium changes in stimulated human eosinophils
67. Modulatory role of protein kinase C on the signal transduction pathway utilized by platelet-activating factor in eosinophil activation
68. 2+ and guanine nucleotides
69. The role of cyclic nucleotides in neutrophil migration
70. ERK1 and ERK2 activation by chemotactic factors in human eosinophils is interleukin 5-dependent and contributes to leukotriene C(4) biosynthesis
71. Analysis of signal transduction pathways in human eosinophils activated by chemoattractants and the T-helper 2-derived cytokines interleukin-4 and interleukin-5
72. Human eosinophils constitutively express a functional interleukin-4 receptor: Interleukin-4-induced priming of chemotactic responses and induction of PI-3 kinase activity
73. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia
74. Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody
75. High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines
76. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
77. The chemokine, eotaxin, activates guinea-pig eosinophils in vitro and causes their accumulation into the lung in vivo
78. Eotaxin-2 activates chemotaxis-related events and release of reactive oxygen species via pertussis toxin-sensitive G proteins in human eosinophils
79. Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases
80. CCR3-active chemokines promote rapid detachment of eosinophils from VCAM-1 in vitro
81. Eotaxin stimulates eosinophil adhesion to human lung microvascular endothelial cells
82. Eotaxin: A potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation
83. Human eotaxin induces eosinophil-derived neurotoxin release from normal human eosinophils
84. The tumor suppressor. PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
85. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
86. SHP1 and SHP2 protein-tyrosine phosphatases associate with beta c after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates
87. Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis
88. Inhibitors keep cytokines in check
89. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
90. Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice
91. Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phosphatase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival
92. Mutagenesis of the beta 2-adrenergic receptor: How structure elucidates function
93. Adrenergic receptors: Recent insights into their mechanism of activation and desensitization
94. G-protein coupled receptor kinases as modulators of G-protein signaling
95. Regulatory mechanisms that modulate signaling by G-protein-coupled receptors
96. A G protein-coupled receptor phosphatase required for rhodopsin function
97. Chemoattractant cross-desensitization of the human neutrophil IL-8 receptor involves receptor internalization and differential receptor subtype regulation
98. Negative cross-talk between RelA and the glucocorticoid receptor: A possible mechanism for the antiinflammatory action of glucocorticoids
99. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor
100. Molecular basis underlying functional pleiotropy of cytokines and growth factors
101. Specificity in cytokine signal transduction: Lessons learned from the IL-3/IL-5/GM-CSF receptor family
102. Integrins and actin filaments: Reciprocal regulation of cell adhesion and signaling
103. Integrins in the immune system
104. A critical role for PI 3-kinase in cytokine-reduced Fcalpha-receptor activation
105. Differential effects of the T helper cell type 2-derived cytokines IL-4 and IL-5 on ligand binding to IgG and IgA receptors expressed by human eosinophils
106. Granulocyte-macrophage colony-stimulating factor induces sequential activation and deactivation of binding via a low-affinity IgG Fc receptor, hFc gamma RII, on human eosinophils
107. In vivo printing of FcalphaR functioning on eosinophils of allergic asthmatics
108. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C
109. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses
110. Immune complex-induced integrin activation and L-plastin phosphorylation require protein kinase A
111. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells
112. Synthesis and characterization of calmodulin antagonistic drugs
113. Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function
114. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
115. Analysis of signal transduction pathways regulating cytokine-mediated Fc receptor activation on human eosinophils
116. Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function
117. The 40-kDa Fc gamma receptor (FcRII) on human neutrophils is essential for the IgG-induced respiratory burst and IgG-induced phagocytosis
118. Lipids on the move: Phosphoinositide 3-kinases in leukocyte function
119. Calcium and signal transduction in granulocytes
120. The respiratory burst oxidase
121. 2)
122. Cytokine-mediated cPLA(2) phosphorylation is regulated by multiple MAPK family members
123. 2 is phosphorylated and activated by MAP kinase
124. Role for tyrosine phosphorylation and Lyn tyrosine kinase in fas receptor-mediated apoptosis in eosinophils
125. Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin 5, whereas only Raf-1 kinase is essential for eosinophil activation and degranulation
126. The differential role of extracellular signal-regulated kinases and p38 mitogen-activated protein kinase in eosinophil functions
127. Expression profiling: DNA arrays in many guises
128. Expression profile of active genes in granulocytes
129. Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: A general mechanism to accumulate effector cells in inflammation
130. Molecular characterization of a granulocyte macrophage-colony-stimulating factor receptor alpha subunit-associated protein
131. Protein transduction: Unrestricted delivery into all cells?
132. In vivo protein transduction: Delivery of a biologically active protein into the mouse
133. A role for the actin-bundling protein L-plastin in the regulation of leukocyte integrin function
134. Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein
135. Biochemical properties, activities, and presence in biologic fluids of eosinophil granule major basic protein
136. Pharmacokinetics and metabolism in early drug discovery
137. Measurement of signal transduction pathways by phosphospecific antibody cell-based ELISA
138. Involvement of IL-5 in a murine model of allergic pulmonary inflammation: Prophylactic and therapeutic effect of an anti-IL-5 antibody
139. SB 24063, a humanized anti-IL-5 monoclonal antibody. Initial single dose safety and activity in patients with asthma
140. A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry
141. The CC chemokine antagonist Met-RANTES inhibits eosinophil effector functions through the chemokine receptors CCR1 and CCR3
142. Differential activation of CC chemokine receptors by AOP-RANTES
143. A potent dimeric peptide antagonist of interleukin-5 that binds two interleukin-5 receptor alpha chains