Expression of Th1 and Th2 immunoregulatory cytokines by human eosinophils

International Archives of Allergy and Immunology

Volumn 118, Issue 2-4, 1999, Pages 95-97

  Woerly, Gaëtane ^a   Roger, Nadine ^a   Loiseau, Sylvie ^a   Capron, Monique ^a,b  

^a INSERM   (France)

^b INSTITUT PASTEUR DE LILLE   (France)

Author keywords

Eosinophils; Th1 Th2 cytokines

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5;

CONFERENCE PAPER; EOSINOPHIL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOREGULATION; PRIORITY JOURNAL;

EID: 0032957948     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000024038     Document Type: Conference Paper

References (12)

1. Desreumaux P, Capron M: Eosinophils in allergic reactions. Curr Opin Immunol 1996;8: 790-795.
2. Dubucquoi S, Capron M: L'éosinophile, une cellule à deux visages dans la réponse inflammatoire; dans L'inflammation. London, Libbey, 1998, pp 55-68.
3. Desreumaux P, Janin A, Colombel JF, Prin L, Plumas J, Emilie D, Torpier G, Capron A, Capron M: Interleukin-5 messenger RNA expression by eosinophils in the intestinal mucosa of patients with coeliac disease. J Exp Med 1992;175:293-296.
4. Dubucquoi S, Desreumaux P, Janin A, Klein O, Goldman M, Tavernier J, Capron A, Capron M: Interleukin 5 synthesis by eosinophils: Association with granules and immunoglobulin-dependent secretion. J Exp Med 1994;179: 703-708.
5. Broide DH, Paine MM, Firestein GS: Eosinophils express interleukin-5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics. J Clin Invest 1992;90:1414-1424.
6. Tanaka YE, Delaporte E, Dubucquoi S, Soussi Gounni A, Porchet E, Capron A, Capron M: IL-5 messenger RNA and immunoreactive protein expression by activated eosinophils in lesional atopic dermatitis skin. J Invest Dermatol 1994:103:589-592.
7. Tomassini M, Tsicopoulos A, Tai PC, Gruart V, Tonnel AB, Prin L, Capron A, Capron M: Release of granule proteins by eosinophils from allergic and nonallergic patients with eosinophilia on immunoglobulin-dependent activation. J Allergy Clin Immunol 1991:88:365-375.
8. Nonaka M, Nonaka R, Woolley K, Adelroth E, Miura K, Okhawara Y, Glibetic M, Nakano K, O'Byrne P, Dolovich J, Jordana M: Distinct immunohistochemical localization of IL-4 in human inflamed airway tissues. Il-4 is localized to eosinophils in vivo and is released by peripheral blood eosinophils. J Immunol 1995; 155:3234-3244.
9. Moqbel R, Ying S, Barkans J, Newman TM, Kimmitt P, Wakelin M, Taborda-Barata L, Meng Q, Corrigan CJ, Durham SR, Kay AB: Identification of messenger RNA for IL-4 in human eosinophils with granule localization and release of the translated product. J Immunol 1995;155:4939-4947.
10. Swain SL, Weinberg AD, English M, Huston G: IL-4 directs the development of Th2-like helper effectors. J Immunol 1990;145:3796-3806.
11. Levi-Schaffer F, Barkans J, Newman TM, Ying S, Wakelin M, Hohenstein R, Barak V, Lacy P, Kay AB, Moqbel R: Identification of interleukin-2 in human peripheral blood eosinophils. Immunology 1996;87:155-161.
12. Lamkhioued B, Soussi Gounni A, Aldebert D, Delaporte E, Prin L, Capron A, Capron, M: Synthesis of type 1 (IFN-γ) and type 2 (IL-4, IL-5, and IL-10) cytokines by human eosinophils. Ann NY Acad Sci 1996;796:203-208.