Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin 5, whereas only Raf-1 kinase is essential for eosinophil activation and degranulation

Journal of Experimental Medicine

Volumn 188, Issue 3, 1998, Pages 421-429

  Pazdrak, Konrad ^a   Olszewska Pazdrak, Barbara ^a   Stafford, Susan ^a   Garofalo, Roberto P ^a   Alam, Rafeul ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Degranulation; Eosinophil; Interleukin 5; Raf 1 kinase; Signal transduction

Indexed keywords

EOSINOPHIL CATIONIC PROTEIN; INTEGRIN; INTERLEUKIN 5; PROTEIN TYROSINE KINASE; TYRPHOSTIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DEGRANULATION; EOSINOPHIL; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

APOPTOSIS; BLOOD PROTEINS; CELL DEGRANULATION; CELL SURVIVAL; ENZYME INHIBITORS; EOSINOPHIL GRANULE PROTEINS; EOSINOPHILS; HUMANS; INTERLEUKIN-5; JANUS KINASE 2; MACROPHAGE-1 ANTIGEN; MITOGENS; NITRILES; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RAF; RIBONUCLEASES; SRC-FAMILY KINASES; TYRPHOSTINS;

EID: 0032479926     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.3.421     Document Type: Article

References (39)

1. Corrigan, C.J., and A.B. Kay. 1992. T cells and eosinophils in the pathogenesis of asthma. Immunol. Today. 13:501-503.
2. Owen, W.F., Jr., and K.F. Austen. 1994. Cytokine regulation of eosinophil-mediated inflammatory reactions by modulation of eosinophil programmed cell death and subsequent priming for augmented function. In Eosinophils In Allergy and Inflammation. G.J. Gleich and A.B. Kay, editors. Marcel Decker, New York. 239-253.
3. Resnick, M.B., and P.F. Weller. 1993. Mechanisms of eosinophil recruitment. Am. J. Res. Cell Mol. Biol. 8:349-355.
4. Yamaguchi, Y., T. Tsuda, J. Suda, M. Eguchi, Y. Miura, N. Harada, A. Tominaga, and K. Takatsu. 1988. Purified interleukin-5 supports the terminal differentiation and proliferation of murine eosinophilic precursors. J. Exp. Med. 167:43-56.
5. Walsh, G.M., A. Hartnell, A.J. Wardlaw, K. Kurihara, C.J. Sanderson, and A.B. Kay. 1990. IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leukocyte integrin (CD11/CD18)-dependent manner. Immunology. 71:258-265.
6. Yamaguchi, Y., T. Sudo, S. Ohata, K. Tominaga, Y. Miura, and T. Kasa. 1991. Analysis of the survival of mature eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils. Blood. 78:2542-2547.
7. Fujisawa, T., R. Abu-Ghazaleh, H. Kita, C.J. Sanderson, and G.J. Gleich. 1990. Regulatory effect of cytokines on eosinophil degranulation. J. Immunol. 144:642-646.
8. Pazdrak, K., D. Schreiber, P. Forsythe, L. Justement, and R. Alam. 1995. The signal transduction mechanism of IL-5 in eosinophils: the involvement of Lyn tyrosine kinase and the Ras-Raf-1-MEK-MAP kinase pathway. J. Exp. Med. 181: 1827-1834.
9. Pazdrak, K., S. Stafford, and R. Alam. 1995. The activation of the Jak-STAT1 signaling pathway in eosinophils by IL-5. J. Immunol. 155:397-402.
10. 59fynT in interleukin-5 receptor signaling. J. Exp. Med. 182: 811-820.
11. Yousefi, S., D.C. Hoessli, K. Blaser, G.B. Mills, and H.U. Simon. 1996. Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils. J. Exp. Med. 183:1407-1414.
12. Pazdrak, K., T. Adachi, and R. Alam. 1997. SHPTP2/SHP2 tyrosine phosphatase is a positive regulator of the interleukin-5 receptor signal transduction pathways leading to the prolongation of eosinophil survival. J. Exp. Med. 186:561-568.
13. Watanabe, S., T. Itoh, and K. Arai. 1996. Jak2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells. J. Biol Chem. 271: 12681-12686.
14. Muszynski, K.W., F.W. Ruscetti, G. Heidecker, U. Rapp, J. Troppmair, J.M. Gooya, and J.R. Keller. 1995. Raf-1 protein is required for growth factor-induced proliferation of hematopoietic cells. J. Exp. Med. 181:2189-2199.
15. Gartner, I. 1980. Separation of human eosinophils in density gradients of polyvinylpyrrolidone-coated silica gel (Percoll). Immunology. 40:133-136.
16. Pazdrak, K., L. Justement, and R. Alam. 1995. Mechanism of inhibition of eosinophil activation by transforming growth factor-β. J. Immunol. 155:4454-4458.
17. Inhorn, R.C., N. Carlesso, M. Durstin, D.A. Frank, and J.D. Griffin. 1995. Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor β chain involving tyrosine-750. Proc. Natl. Acad. Sci. USA. 92: 8665-8669.
18. 2+ independent and accompanied by induction of tyrosine kinase activity. J. Leukoc. Biol. 53:347-353.
19. Meydean, N.T., T. Grunberger, H. Dadi, M. Shahar, E. Arpaia, Z. Lapidot, J.S. Leeder, M. Freedman, A. Cohen, A. Gazit, et al. 1996. Inhibition of acute lymphoblastic leukemia by a Jak-2 inhibitor. Nature. 379:645-648.
20. Beauvais, F., L. Michel, and Dubertret. 1995. Human eosinophils in culture undergo a striking and rapid shrinkage during apoptosis. Role of K+ channels. J. Leukoc. Biol. 57: 861-865.
21. Wooley, K.L., P.G. Gibson, K. Carty, A.J. Wilson, S.H. Twaddell, and M.J. Wooley. 1996. Eosinophil apoptosis and the resolution of airway inflammation in asthma. Am. J. Respir. Crit. Care Med. 154:237-243.
22. Reed, J.C. 1997. Double identity for proteins of the Bcl-2 family. Nature. 387:773-776.
23. Middleton, G., G., Nunez, and A.M. Davies. 1996. Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors. Development (Camb.). 122:695-701.
24. Wang, H.G., U.R. Rapp, and J.C. Reed. 1996 Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell. 81:629-638.
25. Zha, J., H. Harada, E. Yang, J. Jockel, and S.J. Korsmeyer. 1996. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-XL. Cell. 87:619-628.
26. Baffy, G., T. Miyashita, J.R. Wiliamson, and J.G. Reed. 1993. Apoptosis induced by withdrawal of IL-3 from IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production. J. Biol. Chem. 268:6511-6519.
27. Pulverer, B.J., J.M. Kyriakis, J. Avruch, E. Nikolakaki, and J.R. Woodgett. 1991. Phosphorylation of c-jun mediated by MAP kinase. Nature. 353:670-672.
28. Sato, N., K. Sakamaki, N. Terada, K. Arai, and A. Miyajima. 1993. Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common β subunit responsible for different signaling. EMBO (Eur. Mol. Biol. Organ.) J. 11:4181-4189.
29. Rajote, D., H.B. Sadowski, A. Haman, K. Gopalbhai, S. Meloche, L. Liu, G. Krystal, and T. Hoang. 1996. Contribution of both STAT and SRF/TCF to c-fos promoter activation by GM-CSF. Blood. 88:2906-2916.
30. Li, S., and J.M. Sedivy. 1993. Raf-1 protein kinase activates the NFκB transcription factor by dissociating the cytoplasmic NFκB-IκB complex. Proc. Natl. Acad. Sci. USA. 90:9247-9251.
31. Beg, A.A., and D. Baltimore. 1996. An essential role for NFκB in preventing TNF-α-induced cell death. Science. 274: 782-784.
32. Neeley, S.P., K.J. Hamman, S.R. White, S.L. Baranowski, R.A. Burch, and A.R. Leff. 1993. Selective regulation of expression of surface adhesion molecules Mac-1, L-selectin, and VLA-4 on human eosinophils and neutrophils. Am. J. Respir. Cell Mol. Biol. 8:633-638.
33. Blom, M., A.T.J. Tool, P.T.M. Kok, L. Koenderman, D. Roos, and A.J. Verhoeven. 1994. GM-CSF. IL-3 and IL-5 greatly enhance the interaction of human eosinophils with opsonized particles by changing the affinity of complement receptor type 3. Blood. 83:2978-2984.
34. O'Shea, J., E.J. Brown, B.E. Seligmann, J.A. Metcalf, M.M. Frank, and J.I. Gallin. 1985. Evidence for distinct intracellular pools of receptors for C3b and C3bi in human neutrophils. J. Immunol. 134:2580-2585.
35. Sokoloski, J., A.C. Sartorelli, C.A. Rosen, and R. Narayanan. 1993. Antisense oligonucleotides to the p65 subunit of NFkB block CD11b expression and alter adhesion properties of differentiated HL-60 granulocytes. Blood. 82:625-632.
36. 2+ mobilization, but not degranulation, in Lyn-deficient bone marrow-derived mast cells. J. Immunol. 158:2350-2355.
37. Sato, S., T. Katagiri, S. Takaki, Y. Kikuchi, Y. Hitoshi, S. Yonehara, S. Tsukada, D. Kitamura, T. Watanabe, O. Witte, and K. Takatsu. 1994. IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases. J. Exp. Med. 180: 2101-2111.
38. Gold, M.R., V. Duromo, S.P. Saxena, J.W. Schrader, and R. Aebersold. 1994. Multiple cytokmes activate PI-3 kinase in hematopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins. J. Biol. Chem. 269:3403-5412.
39. Hone, S., and H. Kita. 1994. CD11b/CD18 (Mac-1) is required for degranulation of human eosinophils induced by human recombinant granulocyte-macrophage colony stimulating factor and platelet-activating factor. J. Immunol. 152: 5457-5467.