Allergen-specific IgE and IL-5 Are Essential for the Development of Airway Hyperresponsiveness

American Journal of Respiratory Cell and Molecular Biology

Volumn 16, Issue 6, 1997, Pages 674-682

  Hamelmann, Eckard ^a   Oshiba, Akihiro ^a   Schwarze, Jürgen ^a   Bradley, Katherine ^a   Loader, Joan ^a   Larsen, Gary L ^a   Gelfand, Erwin W ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUS MUSCULUS;

ALLERGEN; IMMUNOGLOBULIN E; INTERLEUKIN 5; OVALBUMIN;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BLOOD; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIVISION; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; EOSINOPHIL; FEMALE; IMMUNOLOGY; LEUKOCYTE COUNT; LYMPHOID TISSUE; MOUSE; NUDE MOUSE; PASSIVE IMMUNIZATION; RESPIRATORY TRACT ALLERGY; SMOOTH MUSCLE; TRACHEA;

ALLERGENS; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; EOSINOPHILS; FEMALE; IMMUNIZATION, PASSIVE; IMMUNOGLOBULIN E; INTERLEUKIN-5; LEUKOCYTE COUNT; LYMPHOID TISSUE; MICE; MICE, INBRED BALB C; MICE, NUDE; MUSCLE, SMOOTH; OVALBUMIN; RESPIRATORY HYPERSENSITIVITY; TRACHEA;

EID: 0031156474     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.16.6.9191469     Document Type: Article

References (54)

1. O'Byrne, P. M. 1988. Allergen-induced airway hyperresponsiveness. J. Allergy Clin. Immunol. 81:119-127.
2. Broide, D. H., G. J. Gleich, A. J. Cuomo, D. A. Coburn, E. C. Federman, L. B. Schwartz, and S. I. Wasserman. 1991. Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway. J. Allergy Clin. Immunol. 88:637-648.
3. Rizzo, M. C., L. K. Arruda, M. D. Chapman, E. Fernandez-Caldas, D. Baggio, T. A. Platts-Mills, and C. K. Naspitz. 1993. IgG and IgE antibody responses to dust mite allergens among children with asthma in Brazil. Ann. Allergy 71:152-158.
4. Galli, S. J. 1993. New concepts about the mast cell. N. Engl. J. Med. 328: 257-265.
5. Martin, T. R., T. Takeishi, H. R. Katz, K. F. Austen, J. M. Drazen, and S. J. Galli. 1993. Mast cell activation enhances airway responsiveness to methacholine in the mouse. J. Clin. Invest. 91:1176-1182.
6. Busse, W. W., and J. B. Sedgwick. 1992. Eosinophils in asthma. Ann. Allergy 68:286-290.
7. Kay, A. B., and C. J. Corrigan. 1992. Asthma. Eosinophils and neutrophils. Br. Med. Bull. 48:51-64.
8. Wardlaw, A. J., S. Dunnette, G. J. Gleich, J. V. Collins, and A. B. Kay. 1988. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity. Am. Rev. Respir. Dis. 137:62-69.
9. Azzawi, M., B. Bradley, P. K. Jeffery, A. J. Frew, A. J. Wardlaw, G. Knowles, B. Assoufi, J. V. Collins, S. Durham, and A. B. Kay. 1990. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am. Rev. Respir. Dis. 142:1407-1413.
10. Djukanovic, R., W. R. Roche, J. W. Wilson, C. R. Beasley, O. P. Twentyman, R. H. Howarth, and S. T. Holgate. 1990. Mucosal inflammation in asthma [Review]. Am. Rev. Respir. Dis. 142:434-457.
11. Gibson, P. G., P. J. Manning, P. M. O'Byrne, A. Girgis-Gabardo, J. Dolovich, J. A. Denburg, and F. E. Hargreave. 1991. Allergen-induced asthmatic responses: relationship between increases in airway responsiveness and increases in circulating eosinophils, basophils, and their progenitors. Am. Rev. Respir. Dis. 143:331-335.
12. Dunn, C. J., G. A. Elliott, J. A. Oostveen, and I. M. Richards. 1988. Development of a prolonged eosinophil-rich inflammatory leukocyte infiltration in the guinea-pig asthmatic response to ovalbumin inhalation. Am. Rev. Respir. Dis. 137:541-547.
13. Frew, A. J., R. Moqbel, M. Azzawi, A. Hartnell, J. Barkans, P. K. Jeffery, A. B. Kay, R. J. Scheper, J. Varley, M. K. Church, and S. T. Holgate. 1990. T lymphocytes and eosinophils in allergen-induced late-phase asthmatic reactions in the guinea pig. Am. Rev. Respir. Dis. 141:407-413.
14. Renzi, P. M., R. Olivenstein, and J. G. Martin. 1993. Inflammatory cell populations in the airways and parenchyma after antigen challenge in the rat. Am. Rev. Respir. Dis. 147:967-974.
15. Yamaguchi, Y., Y. Hayashi, Y. Sugama, Y. Miura, T. Kasahara, S. Kitamura, M. Torisu, S. Mita, A. Tominaga, and K. Takatsu. 1988. Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor. J. Exp. Med. 167:1737-1742.
16. Yamaguchi, Y., T. Suda, J. Suda, M. Eguchi, Y. Miura, N. Harada, A. Tominaga, and K. Takatsu. 1988. Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors. J. Exp. Med. 167:43-56.
17. Lopez, A. F., C. J. Sanderson, J. R. Gamble, H. D. Campbell, I. G. Young, and M. A. Vadas. 1988. Recombinant human interleukin 5 is a selective activator of human eosinophil function. J. Exp. Med. 167:219-224.
18. Corrigan, C. J., A. Haczku, V. Gemou-Engesaeth, S. Doi, Y. Kikuchi, K. Takatsu, S. R. Durham, and A. B. Kay. 1993. CD4 T-lymphocyte activation in asthma is accompanied by increased serum concentrations of interleukin-5. Effect of glucocorticoid therapy. Am. Rev. Respir. Dis. 147:540-547.
19. Hamid, Q., M. Azzawi, S. Ying, R. Moqbel, A. J. Wardlaw, C. J. Corrigan, B. Bradley, S. R. Durham, J. V. Collins, P. K. Jeffery, D. J. Quint, and A. B. Kay. 1991. Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J. Clin. Invest. 87:1541-1546.
20. Pretolani, M., J. Lefort, D. Leduc, and B. B. Vargaftig. 1992. Effect of human recombinant interleukin-5 on in vitro responsiveness to PAF of lung from actively sensitized guinea-pigs. Br. J. Pharmacol. 106:677-684.
21. Iwama, T., H. Nagai, N. Tsuruoka, and A. Koda. 1993. Effect of murine recombinant interleukin-5 on bronchial reactivity in guinea-pigs. Clin. Exp. Allergy 23:32-38.
22. Van Oosterhout, A. J., A. R. Ladenius, H. F. Savelkoul, I. Van Ark, K. C. Delsman, and F. P. Nijkamp. 1993. Effect of anti-IL-5 and IL-5 on airway hyperreactivity and eosinophils in guinea pigs. Am. Rev. Respir. Dis. 147: 548-552.
23. Mauser, P. J., A. M. Pitman, X. Fernandez, S. K. Foran, G. K. Adams, 3rd, W. Kreutner, R. W. Egan, and R. W. Chapman. 1995. Effects of an antibody to interleukin-5 in a monkey model of asthma. Am. J. Respir. Crit. Care Med. 152:467-472.
24. Robinson, D. S., Q. Hamid, S. Ying, A. Tsicopoulos, J. Barkans, A. M. Bentley, C. Corrigan, S. R. Durham, and A. B. Kay. 1992. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326:298-304.
25. Lebman, D. A. and R. L. Coffman. 1988. Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures. J. Exp. Med. 168:853-862.
26. Walsh, G. M., A. Hartnell, A. J. Wardlaw, K. Kurihara, C. J. Sanderson, and A. B. Kay. 1990. IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leukocyte integrin (CD11/18)-dependent manner. Immunology 71:258-265.
27. Oshiba, A., E. Hamelmann, K. Takeda, K. L. Bradley, J. E. Loader, G. L. Larsen, and E. W. Gelfand. 1996. Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific IgE and IgG1 in mice. J. Clin. Invest. 97:1398-1408.
28. Renz, H., H. R. Smith, J. E. Henson, B. S. Ray, C. G. Irvin, and E. W. Gelfand. 1992. Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse. J. Allergy Clin. Immunol. 89:1127-1138.
29. Schumacher, J. H., A. O'Garra, B. Shrader, A. van Kimmenade, M. W. Bond, T. R. Mosmann, and R. L. Coffman. 1988. The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent. J. Immunol. 141: 1576-1581.
30. Saloga, J., H. Renz, G. Lack, K. L. Bradley, J. L. Greenstein, G. Larsen, and E. W. Gelfand. 1993. Development and transfer of immediate cutaneous hypersensitivity in mice exposed to aerosolized antigen. J. Clin. Invest. 91:133-140.
31. Larsen, G. L., H. Renz, J. E. Loader, K. L. Bradley, and E. W. Gelfand. 1992. Airway response to electrical field stimulation in sensitized inbred mice: passive transfer of increased responsiveness with peribronchial lymph nodes. J. Clin. Invest. 89:747-752.
32. Larsen, G. L., T. M. Fame, H. Renz, J. E. Loader, J. Graves, M. Hill, and E. W. Gelfand. 1994. Increased acetylcholine release in tracheas from allergen-exposed IgE-immune mice. Am. J. Physiol. 266:263-270.
33. Lavnikova, N., S. Prokhorova, L. Helyar, and D. L. Laskin. 1993. Isolation and partial charaeterization of subpopulations of alveolar macrophages, granulocytes, and highly enriched interstitial macrophages from rat lung. Am. J. Respir. Cell Mol. Biol. 8:384-392.
34. Strath, M., D. J. Warren, and C. J. Sanderson. 1985. Detection of eosinophils using an eosinophil peroxidase assay: its use as an assay for eosinophil differentiation factors. J. Immunol. Methods 83:209-215.
35. Renz, H., K. Bradley, J. Saloga, J. Loader, G. L. Larsen, and E. W. Gelfand. 1993. T cells expressing specific V beta elements regulate immunoglobulin E production and airways responsiveness in vivo. J. Exp. Med. 177:1175-1180.
36. Renz, H., K. Bradley, and E. W. Gelfand. 1996. Production of IL-4 and Interferon-gamma by TCR-Vbeta expressing T-cell subsets in allergen sensitized mice. Am. J. Respir. Cell Mol. Biol. 14:36-43.
37. Hamelmann, E., A. Oshiba, J. Loader, G. L. Larsen, G. J. Gleich, J. Lee, and E. W. Gelfand. 1997. Anti-interleukin-5 (IL-5) antibody prevents airway hyperresponsiveness in a murine model of airway sensitization. Am. J. Respir. Crit. Care Med. (In press)
38. Hamelmann, E., A. Oshiba, J. Paluh, K. Bradley, J. Loader, T. A. Potter, G. L. Larsen, and L. W. Gelfand. 1996. Requirement for CD8+ T cells in the development of airway hyperresponsiveness in a murine model of airway sensitization. J. Exp. Med. 183:1719-1730.
39. Foster, P. S., S. P. Hogan, A. J. Ramsay, K. I. Matthaei, and I. G. Young. 1996. Interleukin 5 deficieney abolishes eosinophilia, airway hyperreactivity, and lung damage in a mouse asthma model. J. Exp. Med. 183:195-201.
40. Corry, D. B., H. G. Folkesson, M. L. Warnock, D. J. Erle, M. A. Matthay, J. P. Wiener-Kronish, and R. M. Locksley. 1996. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 183:109-117.
41. Eum, S. Y., S. Haile, J. Lefort, M. Huerre, and B. B. Vargaftig. 1995. Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin 5-dependent bronchial hyperresponsiveness. Proc. Natl. Acad Sci. USA 92:12290-12294.
42. Drazen, J. M., J. P. Arm, and K. F. Austen. 1996. Sorting out the cytokines of asthma. J. Exp. Med. 183:1-5.
43. Plaut, M., J. H. Pierce, C. J. Watson, J. Hanley-Hyde, R. P. Nordan, and W. E. Paul. 1989. Mast cell lines produce lymphokines in response to cross-linkage of Fe epsilon RI or to calcium ionophores. Nature 339:64-67.
44. Bradding, P., J. A. Roberts, K. M. Britten, S. Montefort, R. Djukanovic, R. Mueller, C. H. Heusser, P. H. Howarth, and S. I. Holgate. 1994. Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am. J. Respir. Cell Mol. Biol. 10:471-480.
45. Rochester, C. L., and J. A. Rankin. 1991. Is asthma T-cell mediated? Am. Rev. Respir. Dis. 144:1005-1007.
46. Bochner, B, S., and R. P. Schleimer. 1994. The role of adhesion molecules in human eosinophil and basophil recruitment. J. Allergy Clin. Immunol. 94: 427-438.
47. Jose P. J., D. A. Griffiths-Johnson, P. D. Collins, D. T. Walsh, R. Moqbel, N. F. Totty, O. Truong, J. J. Hsuan, and T. J. Williams. 1994. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J. Exp. Med. 179:881-887.
48. Arock, M., L. Le Goff, P. A. Becherel, B. Dugas, P. Debre, and M. D. Mossalayi. 1994. Involvement of Fc epsilon RII/CD23 and L-arginine dependent pathway in IgE mediated activation of human eosinophils. Biochem. Biophys. Res. Commun. 203:265-271.
49. Truong, M. J., V. Gruart, F. T. Liu, L. Prin, A. Capron, and M. Capron. 1993. IgF-binding molecules (Mac-2/epsilon BP) expressed by human eosinophils. Implication in IgE-dependent eosinophil cytoloxicity. Eur. J. Immunol. 23:3230-3235.
50. Gounni, A. S., B. Lamkhioued, K. Ochiai, Y. Tanaka, E. Delaporte, A. Capron, J. P. Kinet, and M. Capron. 1994. High-affinily IgE receptor on cosinophils is involved in defense against parasites. Nature 367:183-186.
51. Kaneko, M., M. C. Swanson, G. J. Gleich, and H. Kita. 1995. Allergen-specific IgG1 and IgG3 through Fc gamma RII induce eosinophil degranulation. J. Clin. Invest. 95:2813-2821.
52. Bousquet, J., P. Chanez, J. Y. Lacoste, G. Barneon, N. Ghavanian, I. Enander, P. Venge, S. Ahlstedt, J. Simony-Lafontaine, P, Godard, and F. B. Michel. 1990. Eosinophilic inflammation in asthma. N. Engl. J. Med. 323: 1033-1039.
53. Gulbenkian, A. R., X. Fernandez, W. Kreutner, M. Minnicozzi, A. S. Watnick, T. Kung, and R. W. Egan. 1990. Anaphylactic challenge causes eosinophil accumulation in bronchoalveolar lavage fluid of guinea pigs. Modulation by betamethasone, phenidone, indomethacin. WEB 2086, and a novel antiallergy agent. SCH 37224. Am. Rev. Respir. Dis. 142:680-685.
54. Van Oosterhout, A. J., I. Van Ark, G. Folkerts, H. J. van der Linde, H. F. Savelkoul, A. K. Verheyen, and F. P. Nijkamp. 1995. Antibody to interleukin 5 inhibits virus-induced airway hyperresponsiveness to histamine in guinea pigs. Am. J. Respir. Crit. Care Med. 151:177-183.