Interaction of Stat6 and NF-κB: Direct association and synergistic activation of interleukin-4-induced transcription

Molecular and Cellular Biology

Volumn 18, Issue 6, 1998, Pages 3395-3404

  Shen, Ching Hung ^a   Stavnezer, Janet ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLUTATHIONE TRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; STAT6 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B CELL LYMPHOMA; BINDING SITE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; KIDNEY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0031842614     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.18.6.3395     Document Type: Article

References (40)

1. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141-179.
2. Bhattacharya, S., R. Eckner, S. Grossman, E. Oldread, Z. Arany, A. D'Andrea, and D. M. Livingston. 1996. Cooperation of Stat2 and p300/CBP in signaling induced by interferon-α. Nature 383:344-347.
3. Darnell, J. E., Jr., I. M. Kerr, and G. R. Stark. 1994. Jak-Stat pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421.
4. Delphin, S. A., and J. Stavnezer. 1995. Characterization of an IL-4 responsive region in the immunoglobulin heavy chain ε promoter: regulation by NF-IL4, a C/EBP family member and NF-κB/p50. J. Exp. Med. 181:181-192.
5. Gilman, M. Z., R. N. Wilson, and R. A. Weinberg. 1986. Multiple protein-binding sites in the 5′-flanking region regulate c-fos expression. Mol. Cell. Biol, 6:4305-4316.
6. Gorman, G. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyl transferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
7. Hou, J., U. Schindler, W. J. Henzel, T. C. Ho, M. Brasseur, and S. L. McKnight. 1994. An interleukin-4-induced transcription factor: IL-4 Stat. Science 265:1701-1706.
8. Hsu, H., J. Xiong, and D. V. Goeddel. 1995. The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation. Cell 81:495-504.
9. Iciek, L. A., S. A. Delphin, and J. Stavnezer. 1997. CD40 cross-linking induces IgE germline transcripts in B cells via activation of NF-κB: synergy with IL-4 induction. J. Immunol. 158:4769-4779.
10. Ihle, J. N. 1996. STATs: signal transducers and activators of transcription. Cell 84:331-334.
11. Kaszubska, W., R. H. van Huijsduijnen, P. Ghersa, A.-M. DeRaemy-Schenk, B. P. C. Chen, T. Hai, J. F. DeLamarter, and J. Whelan. 1993. Cyclic AMP-independent ATF family members interact with NF-κB and function in the activation of the E-selection promoter in response to cytokines. Mol. Cell. Biol. 13:7180-7190.
12. Lai, J.-S., and W. Herr. 1992. Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations. Proc. Natl. Acad. Sci. USA 89:6958-6962.
13. LeClair, K. P., M. A. Blanar, and P. A. Sharp. 1992. The p50 subunit of NF-κB associates with NF-IL6 transcription factor. Proc. Natl. Acad. Sci. USA 89:8145-8149.
14. Li, X., S. Leung, S. Qureshi, J. E. Darnell, Jr., and G. R. Stark. 1996. Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-α. J. Biol. Chem. 271:5790-5794.
15. Lin, S. C., and J. Stavnezer. 1996. Activation of NF-κB/Rel by CD40 engagement induces the mouse germline immunoglobulin Cγ1 promoter. Mol. Cell. Biol. 16:4591-4603.
16. Messner, B., A. M. Stutz, B. Albrecht, S. Peiritsch, and M. Woisetschlager. 1997. Cooperation of binding sites for Stat6 and NF-κB/rel in the IL-4-induced up-regulation of the human IgE germline promoter. J. Immunol. 159:3330-3337.
17. Mikita, T., D. Campbell, P. Wu, K. Williamson, and U. Schindler. 1996. Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. Mol. Cell. Biol. 16:5811-5820.
18. Miyamoto, S., M. J. Schmitt, and I. M. Verma. 1994. Qualitative changes in the subunit composition of κB-binding complexes during murine B-cell differentiation. Proc. Natl. Acad. Sci. USA 91:5056-5060.
19. Miyamoto, S., and I. M. Verma. 1995. Rel/NF-κB/IκB story. Adv. Cancer Res. 66:255-292.
20. Ohara, J., and W. E. Paul. 1985. Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature 315:333-336.
21. Ohmori, Y., R. D. Schreiber, and T. A. Hamilton. 1997. Synergy between interferon-γ and tumor necrosis factor-α in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor κB. J. Biol. Chem. 272:14899-14907.
22. Quelle, F. W., K. Shimoda, W. Thierfelder, C. Fischer, A. Kim, S. M. Ruben, J. L. Cleveland, J. H. Pierce, A. D. Keegan, K. Nelms, W. E. Paul, and J. N. Ihle. 1995. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol. Cell. Biol. 15:3336-3343.
23. Qureshi, S. A., M. Salditt-Georgieff, and J. E. Darnell, Jr. 1995. Tyrosine-phosphorylated Stat1 and Stat2 plus 48-kDa proteins all contact DNA in forming interferon-stimulated-gene factor 3. Proc. Natl. Acad. Sci. USA 92:3829-3833.
24. Rice, N. R., and M. K. Ernst. 1993. In vivo control of NF-κB activation by IκBα EMBO J. 12:4685-4695.
25. Richards, M. L., and D. H. Katz. 1997. Analysis of the promoter elements necessary for IL-4 and anti-CD40 antibody induction of murine FcεRII (CD23). Comparison with the germline ε promoter. J. Immunol. 158:263-272.
26. Schaefer, T. S., L. K. Sanders, and D. Nathans. 1995. Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3. Proc. Natl. Acad. Sci. USA 92:9097-9101.
27. Schindler, U., P. Wu, M. Roth, M. Brasseur, and S. L. McKnight. 1995. Components of a Stat recognition code: evidence for two layers of molecular selectivity. Immunity 2:687-697.
28. Schmitz, M. L., and P. A. Baeuerle. 1991. The p65 subunit is responsible for the strong transcription activating potential of NF-κB. EMBO J. 10:3805-3817.
29. Schreiber, E., P. Matthias, M. M. Muller, and W. Schaffner. 1989. Rapid detection of octamer proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17:6419.
30. Seidel, H. M., L. H. Milocco, P. Lamb, J. E. Darnell, Jr., R. B. Stein, and J. Rosen. 1995. Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proc. Natl. Acad. Sci. USA 92:3041-3045.
31. Shirra, M. K., Q. Zhu, H.-C. Huang, D. Pallas, and U. Hansen. 1994. One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs. Mol. Cell. Biol. 14:5076-5087.
32. Shockett, P., and J. Stavnezer. 1991. Effect of cytokines on switching to IgA and α germline transcripts in the B lymphoma I.29μ: transforming growth factor-β activates transcription of the unrearranged Cα gene. J. Immunol. 147:4374-4383.
33. Stavnezer, J. 1996. Antibody class switching. Adv. Immunol. 61:79-146.
34. Stavnezer, J., S. Sirlin, and J. Abbott. 1985. Induction of immunoglohulin isotype switching in cultured I.29μ B lymphoma cells: characterization of the accompanying rearrangements of heavy chain genes. J. Exp. Med. 161:577-601.
35. Stein, B., A. S. Baldwin, Jr., D. W. Ballard, W. C. Greene, P. Angel, and P. Herrlich. 1993. Cross-coupling of the NF-κB p65 and Fos-Jun transcription factors produces potentiated biological function. EMBO J. 12:3879-3891.
36. Stein, B., P. C. Cogswell, and A. S. Baldwin, Jr. 1993. Functional and physical associations between NF-κB and C/EBP family members: a Rel domain-bZIP interaction. Mol. Cell. Biol. 13:3964-3974.
37. Wang, D. Z., A. Cherrington, B. Famakin-Mosuro, and M. Boothby. 1996. Independent pathways for de-repression of the mouse Ig heavy chain germline ε promoter: an IL-4 NAF/NF-1L-4 site as a context-dependent negative element. Int. Immunol. 8:977-989.
38. Warren, W. D., and M. T. Berton. 1995. Induction of germline γ1 and ε Ig gene expression in murine B cells: interleukin 4 and the CD40 ligand-CD40 interaction provide distinct but synergistic signals. J. Immunol. 155:5637-5646.
39. Xu, X., C. Prorock, H. Ishikawa, E. Maldonado, Y. Ito, and C. Gelinas. 1993. Functional interaction of the v-Rel and c-Rel oncoproteins with the TATA-binding protein and association with transcription factor IIB. Mol. Cell. Biol. 13:6733-6741.
40. Zhang, J. J., U. Vinkemeier, W. Gu, D. Chakravarti, C. M. Horvath, and J. E. Darnell, Jr. 1996. Two contact regions between Stat1 and CBP/p300 in interferon γ signaling. Proc. Natl. Acad. Sci. USA 93:15092-15096.