IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-γ

Journal of Immunology

Volumn 162, Issue 1, 1999, Pages 51-59

  Hoshino, Tomoaki ^a   Winkler Pickett, Robin T ^a   Mason, Anna T ^a   Ortaldo, John R ^a   Young, Howard A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 2;

ARTICLE; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; KNOCKOUT GENE; LYMPHOCYTE CLONE; LYMPHOCYTE DIFFERENTIATION; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; T LYMPHOCYTE ACTIVATION;

ANIMALS; CELL LINE; CLONE CELLS; DNA-BINDING PROTEINS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-13; INTERLEUKIN-2; INTERLEUKIN-5; KILLER CELLS, NATURAL; LIVER; LYMPHOCYTE SUBSETS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, SCID; NUCLEAR PROTEINS; SPLEEN; T-LYMPHOCYTES; TRANSPOSASES;

EID: 0032909720     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. 1986. Two types of murine helper T cell clone. 1. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
2. Fiorentino, D. F., M. W. Bond, and T. R. Mosmann. 1989. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170:2081.
3. Del Prete, G. F., M. De Carli, C. Mastromauro, R. Biagiotti, D. Macchia, P. Falagiani, M. Ricci, and S. Romagnani. 1991. Purified protein derivative (PPD) of Mycobacterium tuberculosis and excretory-secretory antigen(s) (TES) of Toxocara canis select human T cell clones with stable and opposite (TH1 or TH2) profiles of cytokine production. J. Clin. Invest. 88:346.
4. + Th0, Th1 and Th2 T cell clones and EBV-transformed B cells. Int. Immunol. 7:1405.
5. de Vries, J. E. 1996, Molecular and biological characteristics of interleukin-13. Chem. Immunol. 63:204.
6. Salgame, P., J. S. Abrams, C. Clayberger, H. Goldstein, J. Convit, R. L. Modlin, and B. R. Bloom. 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 254:279.
7. Powrie, F., and R. L. Coffman. 1993. Cytokine regulation of T-cell function: potential for therapeutic intervention. Immunol. Today 14:270.
8. Kärre, A. 1997. How to recognize a foreign submarine. 1997. Immunol. Rev. 155:1.
9. Young, H. A., and J. R. Ortaldo. 1987. One-signal requirement for interferon-γ production by human large granular lymphocytes. J. Immunol. 139:724.
10. Hayakawa, K., M. A. Salmeron, J. Kornbluth, C. Bucana, and K. Itoh. 1991. The role of IL-4 in proliferation and differentiation of human natural killer cells: study of an IL-4-dependent versus an IL-2-dependent natural killer cell clone. J. Immunol. 146:2453.
11. Hunter, C. A., J. Timans, P. Pisacane, S. Menon, G. Cai, W. Walker, M. Aste-Amezaga, R. Chizzonite, J. F. Bazan, and R. A. Kastelein. 1997. Comparison of the effects of interleukin-1α, interleukin-1β and interferon-γ-inducing factor on the production of interferon-γ by natural killer. Eur. J. Immunol. 27: 2787.
12. Ye, J., J. R. Ortaldo, K. Conlon, R. Winker-Pickett, and H. A. Young. 1995. Cellular and molecular mechanisms of IFN-γ production induced by IL-2 and IL-12 in a human NK cell line. J. Leukoc. Biol. 58:225.
13. Chan, S.H., M. Kobayashi, D. Santoli, B. Perussia, and G. Trinchieri. 1992. Mechanisms of IFN-γ induction by natural killer cell stimulatory factor (NKSF/IL-12): role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2. J. Immunol. 148:92.
14. Okamura, H., H. Tsutsui, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, K. Torigoe, T. Okura, Y. Nukada, K. Hattori, et al. 1995. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 378:88.
15. Bancroft, G. J., K. C. Sheehan, R. D. Schreiber, and E. R. Unanue. 1989. Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in scid mice. J. Immunol. 143:127.
16. Warren, H.S., B. F. Kinnear, J. H. Phillips, and L. L. Lanier. 1995. Production of IL-5 by human NK cells and regulation of IL-5 secretion by IL-4, IL-10, and IL-12. J. Immunol. 154:5144.
17. Mehrotra, P. T., R. P. Donnelly, S. Wong, H. Kanegane, A. Geremew, H. S. Mostowski, K. Furuke, J. P. Siegel, and E. T. Bloom. 1998. Production of IL-10 by human natural killer cells stimulated with IL-2 and/or IL-12. J. Immunol. 160:2637.
18. Voss, S.D., P. M. Sondel, and R. J. Robb. 1992. Characterization of the interleukin 2 receptors (IL-2R) expressed on human natural killer cells activated in vivo by IL-2: association of the p64 IL-2Rγ chain with the IL-2Rβ chain in functional intermediate-affinity IL-2R. J. Exp. Med. 176:531.
19. Carson, W. E., T. A. Fehniger, S. Haldar, K. Eckhert, M. J. Lindemann, C.-F. Lai, C. M. Croce, H. Baumann, and M. A. Caligiuri. 1997. A potential role for interleukin-15 in the regulation of human natural killer cell survival. J. Clin. Invest. 99:937.
20. + hematopoietic progenitor cells. Blood 87:2632.
21. Carson, W. E., J. G. Giri, M. J. Lindemann, M. L. Linett, M. Ahdieh, R. Paxton, D. Anderson, J. Eisenmann, K. Grabstein, and M. A. Caligiuri. 1994. Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J. Exp. Med. 180:1395.
22. Yu, C., R. A. Kirken, M. G. Malabarba, H. A. Young, and J. R. Ortaldo. Differential regulation of the Janus kinase-STAT pathway and biologic function of IL-13 in primary human NK and T cells: a comparative study with IL-4. J. Immunol. 161:218.
23. Punnonen, J., G. Aversa, B. G. Cocks, A. N. J. McKenzie, S. Menon, G. Zurawski, R. de Waal Malefyt, and J. E. de Vries. 1993. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc. Natl. Acad. Sci. USA 90:3730.
24. Orchansky, P. L., S. D. Ayres, D. J. Hilton, and J. W. Schrader. 1997. An interleukin (IL)-13 receptor lacking the cytoplasmic domain fails to transduce IL-13-induced signals and inhibits responses to IL-4. J. Biol. Chem. 272:22940.
25. + T cells in the affected organs of sarcoidosis patients. Clin. Exp. Immunol. 102:399.
26. Hoshino, T., N. Seki, M. Kikuchi, T. Kuramoto, O. Iwamoto, I. Kodama, K. Koufuji, J. Takeda, and K. Itoh. 1997. HLA class-I-restricted and tumor-specific CTL in tumor-infiltrating lymphocytes of patients with gastric cancer. Int. J. Cancer 70:631.
27. Shinkai, Y., G. Tathbun, K.-P. Lam, E. M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A. M. Stall, and F. W. Alt. 1992. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68:855.
28. Dalton, D. K., S. Pitts-Meek, S. Keshav, I. S. Figari, A. Bradley, and T. A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 259:1739.
29. + T cells. J. Immunol. 151:2237.
30. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
31. Watanabe, M., K. L. McCormick, K. Volker, J. R. Ortaldo, J. M. Wigginton, M. J. Brunda, R. H. Wiltrout, and W. E. Fogler. 1997. Regulation of local host-mediated anti-tumor mechanisms by cytokines, Am. J. Pathol. 150:1869.
32. pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179:1285.
33. h2 response and in immunoglobulin E production. Science 270:1845.
34. O'Garra, A. 1998. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8:275.
35. Mason, L. H., P. Gosselin, S. K. Anderson, W. E. Fogler, J. R. Ortaldo, and D. W. McVicar. 1997. Differential tyrosine phosphorylation of inhibitory versus activating Ly-49 receptor proteins and their recruitment of SHP-1 phosphatase. J. Immunol. 159:4187.
36. Wiltrout, R. H., A. M. Pilaro, M. E. Gruys, J. E. Talmadge, D. L. Longo, J. R. Ortaldo, and C. W. Reynolds. 1989. Augmentation of mouse liver-associated natural killer activity by biologic response modifiers occurs largely via rapid recruitment of large granular lymphocytes from the bone marrow. J. Immunol. 143:372.
37. Foy, T. M., A. Aruffo, J. Bajorath, J. E. Buhlmann, and R. J. Noelle. 1996. Immune regulation by CD40 and its ligand gp39. Annu. Rev. Immunol. 14:591.
38. Gauchat, J. F., S. Henchoz, D. Fattah, G. Mazzei, J. P. Aubry, T. Jomotte, L. Dash, K. Page, R. Solari, D. Aldebert, M. Capron, C. Dahinden, and J. Y. Bonnefoy. 1995. CD40 ligand is functionally expressed on human eosinophils. Eur. J. Immunol. 25:863.
39. Grammar, A. C., M. C. Bergman, Y. Miura, K. Fujita, L. S. Davis, and P. E. Lipsky. 1995. The CD40 ligand expressed by human B cells costimulates B cell responses. J. Immunol. 154:4996.
40. Gray, J. D., and D. A. Horwitz. 1995. Activated human NK cells can stimulate resting B cells to secrete immunoglobulins. J. Immunol. 154:5656.
41. Carbone, E., G. Ruggiero, G. Terrazzano, C. Palomba, C. Manzo, S. Fontana, H. Spits, K. Kärre, and S. Zappacost. 1997. A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction. J. Exp. Med. 185:2053.
42. Tanaka, T., F. Kitamura, Y. Nagasaka, K. Kuida, H. Suwa, and M. Miyasaka. 1993. Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor β chain monoclonal antibody in mice. J. Exp. Med. 178: 1103.
43. Veis, D. J., C. M. Sorenson, J. R. Shutter, and S. J. Korsmeyer. 1993. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75:229.
44. Nakayama, K., K.-I. Nakayama, I. Negishi, K. Kuida, H. Sawa, and D. Y. Loh. 1994. Targeted disruption of Bcl-2 αβ in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc. Natl. Acad. Sci. USA 91:3700.
45. Broome, H. E., C. M. Dargan, S. Krajewski, and J. C. Reed. 1995. Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal. J. Immunol. 155:2311.
46. Gajewski, T. F., and F. W. Fitch. 1988. Anti-proliferative effect of IFN-γ in immune regulation. I. IFN-γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J. Immunol. 140:4245.
47. Guide for the Care and Use of Laboratory Animals. National Institutes of Health Publication No. 86-23, 1985. Washington, DC: U.S. Government Printing Office.