Cooperation of Binding Sites for STAT6 and NFκB/rel in the IL-4-Induced Up-Regulation of the Human IgE Germline Promoter

Journal of Immunology

Volumn 159, Issue 7, 1997, Pages 3330-3337

  Messner, Birgit ^a   Stütz, Adrian M ^a   Albrecht, Bettina ^a   Peiritsch, Susanna ^a   Woisetschläger, Maximilian ^a,b  

^a Brunnerstra e 59   (Austria)

^b NOVARTIS Forschungsinstitut Wien   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; ONCOPROTEIN; RELB PROTEIN, HUMAN; STAT6 PROTEIN; STAT6 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RELB;

ARTICLE; B LYMPHOCYTE; BINDING SITE; BURKITT LYMPHOMA; CELL CULTURE; CYTOLOGY; GENETICS; GERM CELL; HUMAN; IMMUNOLOGY; LYMPHOCYTE FUNCTION; METABOLISM; MOLECULAR GENETICS; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROMOTER REGION; SIGNAL TRANSDUCTION; TONSIL; UPREGULATION;

B-LYMPHOCYTES; BASE SEQUENCE; BINDING SITES; BURKITT LYMPHOMA; CELLS, CULTURED; GERM CELLS; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-4; LYMPHOCYTE COOPERATION; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; NF-KAPPA B; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; STAT6 TRANSCRIPTION FACTOR; TONSIL; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR RELB; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0031252357     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Coffman, R. L., D. A. Lebmann, and P. Rothman. 1993. Mechanism and regulation of immunoglobulin isotype switching. In Advances in Immunology, Vol. 54. F. J. Dixon, ed. Academic Press, San Diego, p. 229.
2. Stavnezer, J. 1996. Immunoglobulin class switching. Curr. Opin. Immunol. 8: 199.
3. Jung, S., K. Rajewsky, and A. Radbruch. 1993. Shutdown of class switch recombination by deletion of a switch region control element. Science 259:984.
4. Zhang, J., A. Bottaro, S. Li, V. Stewart, and F. W. Alt. 1993. A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon. EMBO J. 12:3529.
5. Gauchat, J.-F., G. G. Aversa, H. Gascan, R. De Waal Malefyt, and J. E. De Vries. 1992. Regulation of human IgE-asynthesis. In IL4: Structure and Function. H. Spits, ed. CRC Press, Boca Raton, p. 89.
6. Rothman, P., S. Lutzker, W. Cook, R. Coffman, and F. W. Alt. 1988. Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells. J. Exp. Med. 168:2385.
7. Rothman, P., Y. Y. Chen, S. Lutzker, S. C. Li, V. Stewart, R. Coffman, and F. W. Alt. 1990. Structure and expression of germ line immunoglobulin heavy-chain epsilon transcripts: interleukin-4 plus lipopolysaccharide-directed switching to C epsilon. Mol. Cell. Biol. 10:1672.
8. Gerondakis, S. 1990. Structure and expression of murine germ-line immunoglobulin epsilon heavy chain transcripts induced by interleukin 4. Proc. Natl. Acad. Sci. USA 87:1581.
9. Gauchat, J. F., D. A. Lebman, R. L. Coffman, H. Gascan, and J. E. De Vries. 1990. Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE-E production. J. Exp. Med. 172:463.
10. Punnonen, J., G. G. Aversa, B. G. Cocks, A. N. J. McKenzie, S. Menon, G. Zurawski, R. De Waal Malefyt, and J. E. De Vries. 1993. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc. Natl. Acad. Sci. USA 90:3730.
11. Albrecht, B., S. Peiritsch, and M. Woisetschlaeger. 1994. A bifunctional control element in the human IgE germline promoter involved in repression and IL-4 activation. Int. Immunol. 6:1143.
12. Ichiki, T., W. Takahashi, and T. Watanabe. 1993. Regulation of the expression of human C∈ germline transcript: identification of a novel IL-4 responsive element. J. Immunol. 150:5408.
13. Köhler, I., and E. P. Rieber. 1993. Allergy-associated I epsilon and Fc epsilon receptor II (CD23b) genes activated via binding of an interleukin-4-induced transcription factor to a novel responsive element. Eur. J. Immunol. 23:3066.
14. Rothman, P., S. C. Li, B. Gorham, L. Glimcher, F. W. Alt, and M. Boothby. 1991. Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line ∈ transcripts. Mol. Cell. Biol. 11:5551.
15. Fenghao, X., A. Saxon, A. Nguyen, Z. Ke, D. Diaz-Sanchez, and A. Nel. 1995. Interleukin 4 activates a signal transducer and activator of transcription (Stat) protein which interacts with an interferon-γ activation site-like sequence upstream of the I∈ exon in a human B cell line: evidence for the involvement of janus kinase 3 and interleukin-4 Stat. J. Clin. Invest. 96:907.
16. Hou, J., U. Schindler, W. J. Henzel, T. C. Ho, M. Brasseur, and S. L. McKnight. 1994. An interleukin-4-induced transcription factor: IL-4 Stat. Science 265:1701.
17. Takeda, K., T. Tanaka, W. Shi, M. Matsumoto, M. Minami, S. Kashiwamura, K. Nakanishi, N. Yoshida, T. Kishimoto, and S. Akira. 1996. Essential role of Stat6 in IL-4 signalling. Nature 380:627.
18. Shimoda, K., J. van Deursen, M. Y. Sangster, S. R. Sarawar, R. T. Carson, R. A. Tripp, C. Chu, F. W. Quelle, T. Nosaka, D. A. A. Vignali, P. C. Doherty, G. Grosveld, W. E. Paul, and J. N. Ihle. 1996. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380:630.
19. Kaplan, M. H., U. Schindler, S. T. Smiley, and M. J. Grusby. 1996. Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 4:313.
20. Yssel, H., J. E. De Vries, M. Koken, W. Van Blitterswijk, and H. Spits. 1984. Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones. J. Immunol. Methods 72:219.
21. Ho, S. N., H. D. Hunt, R. M. Horton, J. K. Pullen, and L. R. Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51.
22. Andrews, N. C., and D. V. Faller. 1991. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19:2499.
23. Delphin, S., and J. Stavnezer. 1995. Characterization of an Interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline ∈ promoter: regulation by NF-IL-4, a C/EBP family member and NF-ΚB/p50. J. Exp. Med. 181:181.
24. Wang, D. Z., A. Cherrington, B. Famakin-Mosuro, and M. Boothby. 1996. Independent pathways of the mouse Ig heavy chain germ-line ∈ promoter: an IL-4 NAF/NF-IL-4 site as a context-dependent negative element. Int. Immunol. 8:977.
25. Kotanides, H., and N. C. Reich. 1993. Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4. Science 262:1265.
26. Schindler, C., H. Kashleva, A. Pernis, R. Pine, and P. Rothman. 1994. STF-IL-4: a novel IL-4-induced signal transducing factor. EMBO J. 13:1350.
27. Ryseck, R.-P., P. Bull, M. Takamiya, V. Bours, U. Siebenlist, P. Dobrzanski, and R. Bravo. 1992. RelB, a new Rel family transcription activator that can interact with p50-NF-ΚB. Mol. Cell. Biol. 12:674.
28. Lernbecher, T., U. Müller, and T. Wirth. 1993. Distinct NF-ΚB/Rel transcription factors are responsible for tissue-specific and inducible gene activation. Nature 365:767.
29. Gauchat, J.-F., G. G. Aversa, H. Gascan, and J. E. de Vries. 1992. Modulation of IL-4 induced germline epsilon RNA synthesis in human B cells by tumor necrosis factor-alpha, anti-CD40 monoclonal antibodies or transforming growth factor-beta correlates with levels of IgB production. Int. Immunol. 4:397.
30. Berberich, I., G. L. Shu, and E. A. Clark. 1994. Cross-linking CD40 on B cells rapidly activates nuclear factor-KB. J. Immunol. 153:4357.
31. Iciek, L. A., S. A. Delphin, and J. Stavnezer. 1997. CD40 Cross-linking induces Ig∈ germline transcripts in B cells via activation of NF-ΚB. J. Immunol. 158: 4769.
32. Falvo, J. V., D. Thanos, and T. Maniatis. 1995. Reversal of intrinsic DNA bends in the IFNJ gene enhancer by transcription factors and the architectural protein HMG I(Y). Cell 83:1101.
33. Thanos, D., and T. Maniatis. 1995. NF-ΚB: a lesson in family values. Cell 80: 529.
34. Schreck, R., H. Zorbas, E.-L. Winnacker, and P. A. Baeuerle. 1990. The NF-ΚB transcription factor induces DNA bending which is modulated by its 65-kD subunit. Nucleic Acids Res. 18:6497.
35. Lewis, H., W. Kaszubska, J. F. de Lamarter, and J. Whelan. 1994. Cooperativity between two NF-ΚB complexes, mediated by high-mobility-group I(Y), is essential for cytokine induced expression of the E-selectin promoter. Mol. Cell. Biol. 14:5701.
36. Kaszubska, W., R. H. van Huijsduijnen, P. Ghersa, A.-M. deRaemy-Schenk, B. P. C. Chen, T. Hai, J. F. de Lamarter, and J. Whelan. 1993. Cyclic AMP-independent ATF family members interact with NF-ΚB and function in the activation of the E-selectin promoter in response to cytokines. Mol. Cell. Biol. 13:7180.
37. Whitley, M. Z., D. Thanos, M. A. Read, T. Maniatis, and T. Collins. 1994. A striking similarity in the organization of the E-selectin and beta interferon gene promoters. Mol. Cell. Biol 14:6464.
38. LeClair, K. P., M. A. Blanar, and P. A. Sharp. 1992. The p50 subunit of NF-ΚB associates with the NF-IL6 transcription factor. Proc. Natl. Acad. Sci. USA 89: 8145.
39. Stein, B., P. C. Cogswell, and A. S. Baldwin, Jr. 1993. Functional and physical associations between NF-ΚB and C/EBP family members: a Rel domain-bZIP interaction. Mol. Cell. Biol. 13:3964.
40. Stein, B., and A. S. Baldwin, Jr. 1993. Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-ΚB. Mol. Cell. Biol. 13:7191.
41. John, S., R. B. Reeves, J.-X. Lin, R. Child, J. M. Leiden, C. B. Thompson, and W. J. Leonard. 1995. Regulation of cell-type-specific interleukin-2 receptor α-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-ΚB family proteins. Mol. Cell. Biol. 15:1786.
42. Sha, W. C., H.-C. Liou, E. I. Tuomanen, and D. Baltimore. 1995. Targeted disruption of the p50 subunit of NF-ΚB leads to multifocal defects in immune responses. Cell 80:321.
43. H transcription, and Ig class switching. J. Immunol. 156:183.
44. Snapper, C. M., F. R. Rosas, P. Zelazowski, M. A. Moorman, M. R. Kehry, R. Bravo, and F. Weih. 1996. B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching. J. Exp. Med. 184:1537.