The cysteine protease activity of the major dust mite allergen der p 1 selectively enhances the immunoglobulin E antibody response

Journal of Experimental Medicine

Volumn 190, Issue 12, 1999, Pages 1897-1901

  Gough, Lucy ^a   Schulz, Oliver ^a   Sewell, Herb F ^a   Shakib, Farouk ^a,b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

Cysteine protease; Der p 1; IgE

Indexed keywords

ALLERGEN; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; IMMUNOGLOBULIN E;

ALLERGENICITY; ANIMAL CELL; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DERMATOPHAGOIDES PTERONYSSINUS; ENZYME ACTIVITY; HYPERSENSITIVITY REACTION; IMMUNIZATION; IMMUNOGLOBULIN PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ALLERGENS; ANIMALS; ANTIBODIES; ANTIGENS; ANTIGENS, DERMATOPHAGOIDES; CYSTEINE ENDOPEPTIDASES; GLYCOPROTEINS; IMMUNOGLOBULIN E; MICE; MITES;

EID: 0033388991     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.12.1897     Document Type: Article

References (16)

1. Sutton, B.J., and H.J. Gould. 1993. The human IgE network. Nature. 366:421-428.
2. Tovey, E.R., M.D. Chapman, and T.A.E. Harts-Mills. 1981. Mite faeces are a major source of house dust allergens. Nature. 289:592-593.
3. Shakib, F., O. Schulz, and H.F. Sewell. 1998. A mite subversive: cleavage of CD23 and CD25 by Der p 1 enhances allergenicity. Immunol. Today. 19:313-316.
4. Schulz, O., H.F. Sewell, and F. Shakib. 1998. Proteolytic cleavage of CD25, the α subunit of the human T cell interleukin 2 receptor, by Der p 1, a major mite allergen with cysteine protease activity. J. Exp. Med. 187:271-275.
5. Abbas, A.K., K.M. Murphy, and A. Sher. 1996. Functional diversity ot helper T lymphocytes. Nature. 383:787-793.
6. Schulz, O., H.F. Sewell, and F. Shakib. 1998. A sensitive fluorescent assay tor measuring the cysteine protease activity of Der p 1, a major allergen from the dust mite Dermatophagoides pteronyssinus. Mol. Pathol. 51:222-224.
7. Topham, C.M., N. Srinivasan, C.J. Thorpe, J.P. Overington, and N.A. Kalsheker. 1994. Comparative modelling of major house dust mite allergen Der p 1: structure validation using an extended environmental animo acid propensity table. Protein Eng. 7:869-894.
8. Chua, K.Y., G.A. Stewart, W.K. Thomas, R.J. Simpson, R.J. Dilworth, T.M. Plozza, and K.J. Turner. 1988. Sequence analysis of cDNA coding for a major house dust mite allergen, Der p 1. Homology with cysteine proteases. J. Exp. Med. 167:175-182.
9. Barrett, A.J., A.A. Kembhavi, M.A. Brown, H. Kirschke, C.G. Knight, M. Tamai, and K. Hanada. 1982. L-trans-epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem. J. 201:189-198.
10. Yamamoto, D., K. Matsumoto, H. Ohishi, T. Ishida, M. Inoue, K. Kitamura, and H. Mizuno. 1991. Refined x-ray structure of papain.E-64-c complex at 2.1-A resolution. J. Biol. Chem. 266:14771-14777.
11. Cosman, D., D.P. Cerretti, A. Larsen, L. Park, C. March, S. Dower, S. Gillis, and D. Urdal. 1984. Cloning, sequence and expression of human interleukin-2 receptor. Nature. 312: 768-771.
12. Miller, J., T.R. Malek, W.J. Leonard, W.C. Greene, E.M. Shevach, and R.N. Germain. 1985. Nucleotide sequence and expression of a mouse interleukin 2 receptor cDNA. J. Immunol. 134:4212-4217.
13. Comoy, E.E., J. Pestel, C. Duez, G.A. Stewart, C. Vendeville, C. Fournier, F. Finkelman, A. Capron, and G. Thyphronitis. 1998. The house dust mite allergen, Dermatophagoides pteronyssinus, promotes type 2 responses by modulating the balance between IL-4 and IFN-γ. J. Immunol. 160:2456-2462.
14. Alexander, J., G.H. Coombs, and J.C. Mottram. 1998. Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a Th1 response. J. Immunol. 161:6794-6801.
15. Herbert, C.A., C.M. King, P.C. Ring, S.T. Holgate, G.A. Stewart, P.J. Thompson, and C. Robinson. 1995. Augmentation of permeability in the bronchial epithelium by the house dust mite allergen Der p 1. Am. J. Respir. Cell Mol. Biol. 12:369-378.
16. Winton, H.L., H. Wan, M.B. Cannell, P.J. Thompson, D.R. Garrod, G.A. Stewart, and C. Robinson. 1998. Class specific inhibition of house dust mite proteinases which cleave cell adhesion, induce cell death and which increase the permeability of lung epithelium. Br. J. Pharmacol. 124:1048-1059.