A murine model of allergic rhinitis: Studies on the role of IgE in pathogenesis and analysis of the eosinophil influx elicited by allergen and eotaxin

Journal of Allergy and Clinical Immunology

Volumn 102, Issue 1, 1998, Pages 65-74

  Van De Rijn, Matthijs ^a   Mehlhop, Paul D ^b   Judkins, Alex ^a   Rothenberg, Marc E ^c   Luster, Andrew D ^d   Oettgen, Hans C ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Allergic rhinitis; Eotaxin; IgE; IL 5; Mouse model

Indexed keywords

CHEMOKINE; EOTAXIN; IMMUNOGLOBULIN E; INTERLEUKIN 5;

ALLERGIC RHINITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ARTICLE; CELL INFILTRATION; EOSINOPHIL; HISTOPATHOLOGY; IMMUNOPATHOGENESIS; INFLAMMATORY CELL; LEUKOCYTE MIGRATION; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; NOSE MUCOSA; PRIORITY JOURNAL; TIME;

EID: 0031844008     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(98)70056-9     Document Type: Article

References (64)

1. Settipane GA. Allergic rhinitis - an update. Otolaryngol Head Neck Surg 1986;94:470-5.
2. Nathan RA, Meltzer EO, Selner JC, Storms W. Prevalence of allergic rhinitis in the United States. J Allergy Clin Immunol 1997;99:S808-14.
3. Meltzer EO, Nathan RA, Selner JC, Storms W. Quality of life and rhinitic symptoms: results of a nationwide survey with the SF-36 and RQLQ questionnaires. J Allergy Clin Immunol 1997;99:S815-9.
4. Bentley AM, Jacobson MR, Cumberworth V, Barkans JR, Moqbel R, Schwartz LB, et al. Immunohistology of the nasal mucosa in seasonal allergic rhinitis: increases in activated eosinophils and epithelial mast cells. J Allergy Clin Immunol 1992;89:877-83.
5. Naclerio RM, Baroody FM, Kagey-Sobotka A, Lichtenstein LM. Basophils and eosinophils in allergic rhinitis. J Allergy Clin Immunol 1994;94(suppl):1303-9.
6. Varney VA, Jacobson MR, Sudderick RM, Robinson DS, Irani AM, Schwartz LB, et al. Immunohistology of the nasal mucosa following allergen-induced rhinitis. Identification of activated T lymphocytes, eosinophils, and neutrophils. Am Rev Respir Dis 1992;146:170-6.
7. Rennick DM, Thompson SL, Coffman RL, Seymour BW, Jackson JD, Hudak S. In vivo administration of antibody to interleukin-5 inhibits increased generation of eosinophils and their progenitors in bone marrow of parasitized mice. Blood 1990;76:312-6.
8. Nakajima H, Iwamoto I, Tomoe S, Matsumura R, Tomioka H, Takatsu K, et al. CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. Am Rev Respir Dis 1992;146:374-7.
9. Foster PS, Hogan SP, Ramsay AJ, Matthaei KI, Young IG. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J Exp Med 1996;183:195-201.
10. Walsh GM, Mermod JJ, Hartnell A, Kay AB, Wardlaw AJ. Human eosinophil, but not neutrophil, adherence to IL-1-stimulated human umbilical vascular endothelial cells is alpha 4 beta 1 (very late antigen-4) dependent. J Immunol 1991;146:3419-23.
11. Bochner BS, Luscinskas FW, Gimbrone MJ, Newman W, Sterbinsky SA, Derse AC, et al. Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules. J Exp Med 1991;173:1553-7.
12. Weg VB, Williams TJ, Lobb RR, Nourshargh S. A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo. J Exp Med 1993;177:561-6.
13. Jose PJ, Griffiths-Johnson DA, Collins PD, Walsh DT, Moqbel R, Totty NF, et al. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J Exp Med 1994;179:881-7.
14. Rothenberg ME, Luster AD, Leder P. Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression. Proc Natl Acad Sci USA 1995;92:8960-4.
15. Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat Med 1996;2:449-56.
16. Baraniuk JN. Pathogenesis of allergic rhinitis. J Allergy Clin Immunol 1997;99:S763-72.
17. Druce HM. Allergic and nonallergic rhinitis. In: Middleton E, Reed CE, Ellis EF, Adkinson NF, Yunginger JW, Busse WW, editors. Allergy principles and practice. St. Louis: Mosby; 1993. p. 1433-53.
18. Tada T, Ishizaka K. Distribution of gamma E-forming cells in lymphoid tissues of the human and monkey. J Immunol 1970;104:377-87.
19. Bascom R, Pipkorn U, Lichtenstein LM, Naclerio RM. The influx of inflammatory cells into nasal washings during the late response to antigen challenge. Effect of systemic steroid pretreatment. Am Rev Respir Dis 1988;138:406-12.
20. Iliopoulos O, Proud D, Adkinson NFJ, Norman PS, Kagey-Sabotka A, Lichtenstein LM, et al. Relationship between the early, late and rechallenge reaction to nasal challenge with antigen: observations on the role of inflammatory mediators and cells. J Allergy Clin Immunol 1990;86:851-61.
21. Kehry MR, Yamashita LC. Low-affinity IgE receptor (CD23) function on mouse B cells: role in IgE-dependent antigen focusing. Proc Natl Acad Sci USA 1989;86:7556-60.
22. Heyman B, Liu T, Gustavsson S. In vivo enhancement of the specific antibody response via the low-affinity receptor for IgE. Eur J Immunol 1993;23:1739-42.
23. Gustavsson S, Hjulstrom S, Liu T, Heyman B. CD23/IgE-mediated regulation of the specific antibody response in vivo. J Immunol 1994;152:4793-800.
24. Fujiwara H, Kikutani H, Suematsu S, Naka T, Yoshida K, Yoshida K, et al. The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice. Proc Natl Acad Sci USA 1994;91:6835-9.
25. Mudde GC, Bheekha R, Bruijnzeel-Koomen CAFM. Consequences of IgE/CD23-mediated antigen presentation in allergy. Immunol Today 1995;16:380-3.
26. Lack G, Oshiba A, Bradley KL, Loader JE, Amran D, Larsen GL, et al. Transfer of immediate hypersensitivity and airway hyperresponsiveness by IgE-positive B cells. Am J Respir Crit Care Med 1995;152:1765-73.
27. Eum S, Haile S, Lefort J, Huerre M, Vargaftig BB. Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin 5-dependent bronchial hyperresponsiveness. Proc Natl Acad Sci USA 1995;92:12290-4.
28. Coyle AJ, Wagner K, Bertrand C, Tsuyuki S, Bews J, Heusser C. Central role of immunoglobulin (Ig) E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: inhibition by a non-anaphylactogenic anti-IgE antibody. J Exp Med 1996;183:1303-10.
29. Wang D, Clement P, De Waele M, Derde MP. Study of nasal cytology in atopic patients after nasal allergen challenge. Rhinology 1995;33:78-81.
30. Wang DY, Clement P, Smitz J, De Waele M, Derde MP. Quantification of eosinophil cationic protein and eosinophils in nasal secretions of allergen-induced nasal inflammation. Allergol Immunopathol 1994;22:179-83.
31. Beppu T, Ohta N, Gon S, Sakata K, Inamura K, Fukase S, et al. Eosinophil and eosinophil cationic protein in allergic rhinitis. Acta Otolaryngol Suppl (Stockh) 1994;511:221-3.
32. Lim MC, Taylor RM, Naclerio RM. The histology of allergic rhinitis and its comparison to cellular changes in nasal lavage. Am J Respir Crit Care Med 1995;151:136-44.
33. Igarashi Y, Goldrich MS, Kaliner MA, Irani AM, Schwartz LB, White MV. Quantitation of inflammatory cells in the nasal mucosa of patients with allergic rhinitis and normal subjects. J Allergy Clin Immunol 1995;95:716-25.
34. Minshall E, Cameron L, Lavigne F, Leung DM, Hamilos D, Garcia-Zepeda EA, et al. Eotaxin mRNA expression in chronic sinusitis and allergen-induced nasal responses in seasonal allergic rhinitis. Am J Respir Cell Mol Biol 1997;17:683-90.
35. Kokron CM, Bonilla FA, Oettgen HC, Ramesh N, Geha RS, Pandolfi F. Searching for genes involved in the pathogenesis of primary immunodeficiency diseases: lessons from mouse knockouts. J Clin Immunol 1997;17:109-26.
36. Renz H, Smith HR, Henson JE, Ray BS, Irvin CG, Gelfand EW. Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse. J Allergy Clin Immunol 1992;89:1127-38.
37. Kurup VP, Mauze S, Choi H, Seymour BW, Coffman RL. A murine model of allergic broncho pulmonary aspergillosis with elevated eosinophils and IgE. J Immunol 1992;148:3783-8.
38. Brusselle GG, Kips JC, Tavernier JH, van der Heyden JG, Cuvelier CA, Pauwels RA, et al. Attenuation of allergic airway inflammation in IL-4 deficient mice. Clin Exp Allergy 1994;24:73-80.
39. Mehlhop PD, van de Rijn M, Goldberg AB, Kurup VP, Martin TR, Oettgen HC. Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma. Proc Natl Acad Sci USA 1997;94:1344-9.
40. MacLean JA, Ownbey R, Luster AD. T cell-dependent regulation of eotaxin in antigen-induced pulmonary eosinophilia. J Exp Med 1996;184:1461-9.
41. Merayo-Lloves J, Zhao TZ, Dutt JE, Foster CS. A new murine model of allergic conjunctivitis and effectiveness of nedocromil sodium. J Allergy Clin Immunol 1996;97:1129-40.
42. Tanaka K, Okamoto Y, Nagaya Y, Nishimura F, Takeoka A, Hanada S, et al. A nasal allergy model developed in the guinea pig by intranasal application of 2,4-toluazene diisocyanate. Int Arch Allergy Appl Immunol 1988;85:392-7.
43. Ishida M, Amesara R, Ukai K, Sakakura Y Antigen (DNP-As)-induced allergic rhinitis model in guinea pigs. Ann Allergy 1994;72:240-4.
44. Takahashi N, Aramaki Y, Tsuchiya S. Allergic rhinitis model with Brown Norway rat and evaluation of antiallergic drugs. J Pharmacobiodynamics 1990;13:414-20.
45. Oettgen HC, Martin TR, Wynshaw-Boris A, Deng C, Drazen JM, Leder P. Active anaphylaxis in IgE-deficient mice. Nature 1994;370:367-70.
46. Dent LA, Strath M, Mellor AL, Sanderson CJ. Eosinophilia in transgenic mice expressing interleukin 5. J Exp Med 1990;172:1425-31.
47. Rothenberg ME, Ownbey R, Mehlhop PD, Loiselle M, van de Rijn M, Bonventre JV, et al. Eotaxin triggers eosinophil selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin-5 in mice. Mol Med 1996;2:334-48.
48. Luna LG. AFIP manual of histologic staining methods. New York: McGraw Hill; 1986.
49. Kurup VW, Seymour BWP, Choi H, Coffman RL. Particulate Aspergillus fumigatus antigens elicit a Th2 response in BALB/c mice. J Allergy Clin Immunol 1994;93:1013-20.
50. Jose PJ, Adcock IM, Griffiths-Johnson DA, Berkman N, Wells TN, Williams TJ, et al. Eotaxin: cloning of an eosinophil chemoattractant cytokine and increased mRNA expression in allergen-challenged guinea-pig lungs. Biochem Biophys Res Commun 1994;205:788-94.
51. Collins PD, Marleau S, Griffiths-Johnson DA, Jose PJ, Williams TJ. Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. J Exp Med 1995;182:1169-74.
52. Mould AW, Matthaei KI, Young IG, Foster PS. Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice. J Clin Invest 1997;99:1064-71.
53. Kurup VP, Choi H, Resnick A, Kalbfleisch J, Fink JN. Immunopathological response of C57BL/6 and C3H/HeN mice to Aspergillus fumigatus antigens. Int Arch Allergy Appl Immunol 1990;91:145-54.
54. Murali PS, Dai G, Kumar A, Fink JN, Kurup VP. Aspergillus antigen-induced eosinophil differentiation in a murine model. Infect Immun 1992;60:1952-6.
55. Murali PS, Kumar A, Choi H, Bansal NK, Fink JN, Kurup VP. Aspergillus fumigatus antigen induced eosinophilia in mice is abrogated by anti-IL-5 antibody. J Leukoc Biol 1993;53:264-7.
56. Kurup VP, Choi H, Murali PS, Coffman RL. IgE and eosinophil regulation in a murine model of allergic aspergillosis. J Leukoc Biol 1994;56:593-8.
57. Fox PC, Basciano LK, Siraganian RP. Mouse mast cell activation and desensitization for immune aggregate-induced histamine release. J Immunol 1982;129:314-9.
58. Katz HR, Raizman MB, Gartner CS, Scott HC, Benson AC, Austen KF. Secretory granule mediator release and generation of oxidative metabolites of arachidonic acid via Fc-IgG receptor bridging in mouse mast cells. J Immunol 1992;148:868-71.
59. Vaz EM, Silveira IHS, Dodd VMB, Monteiro MR, Vaz NM. Anaphylactic antibodies in mouse. Int Arch Allergy 1970;39:459-68.
60. Nussenzweig RS, Merryman C, Benacerraf B. Electrophoretic separation and properties of mouse anti-hapten antibodies involved in passive cutaneous anaphylaxis and passive hemolysis. J Exp Med 1964;120:315-28.
61. Garssen J, Nijkamp FP, Van Der Vliet H, Van Loveren H. A role for T helper-1 cells in the induction of airway hyperresponsiveness. Chest 1993;103(suppl):129S-30S.
62. Garssen J, Van Loveren H, Van Der Vliet H, Bot H, Nijkamp FP. T cell-mediated induction of airway hyperresponsiveness and altered lung functions in mice are independent of increased vascular permeability and mononuclear cell infiltration. Am Rev Respir Dis 1993;147:307-13.
63. Pipkorn U, Karlsson G, Enerback L. Nasal mucosal response to repeated challenges with pollen allergen. Am Rev Respir Dis 1989;140:729-36.
64. Burke-Gaffney A, Hellewell PG. Eotaxin stimulates eosinophil adhesion to human lung microvascular endothelial cells. Biochem Biophys Res Commun 1996;227:35-40.