Self glycolipids as T-cell autoantigens

European Journal of Immunology

Volumn 29, Issue 5, 1999, Pages 1667-1675

  Shamshiev, Abdijapar ^a   Donda, Alena ^a   Carena, Ilaria ^a   Mori, Lucia ^a   Kappos, Ludwig ^a   De Libero, Gennaro ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Autoimmunity; CD1; Glycolipid; Multiple sclerosis; TCR

Indexed keywords

AUTOANTIGEN; CD8 ANTIGEN; GALACTOSYLCERAMIDE; GAMMA INTERFERON; GANGLIOSIDE; GLYCOLIPID; SULFATIDE; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD1; AUTOANTIGENS; CARBOHYDRATE SEQUENCE; CATTLE; CELL LINE; FEMALE; G(M1) GANGLIOSIDE; GANGLIOSIDES; GLYCOLIPIDS; HUMANS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MULTIPLE SCLEROSIS; RECEPTOR-CD3 COMPLEX, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 0032902960     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199905)29:05<1667::AID-IMMU1667>3.0.CO;2-U     Document Type: Article

References (33)

1. Lucchinetti, C. F., Bruck, W., Rodriguez, M. and Lassmann, H., Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis. Brain Pathol. 1996. 6: 259-74.
2. Moore, G. R. and Raine, C. S., Immunogold localization and analysis of IgG during immune-mediated demyelination. Lab. Invest. 1988. 59: 641-8.
3. Lassmann, H. and Wisniewski, H. M., Chronic relapsing experimental allergic encephalomyelitis: morphological sequence of myelin degradation. Brain Res. 1979. 169: 357-68.
4. Lumsden, C. E., The neuropathology of multiple sclerosis. In Vinken, P. I. and Bruyn, G. W. (Eds.), Handbook of Clinical Neurology, Elsevier, New York 1970, p. 217-309.
5. - T lymphocytes to a microbial antigen. Nature 1992. 360: 593-7.
6. + T cells. Nature 1994. 372: 691-4.
7. Sieling, P. A., Chatterjee, D., Porcelli, S. A., Prigozy, T. I., Mazzaccaro, R. J., Soriano, T., Bloom, B. R., Brenner, M. B., Kronenberg, M., Brennan, P. J. and Modlin, R. L., CD1-restricted T cell recognition of microbial lipoglycan antigens. Science 1995. 269: 227-30.
8. Battistini, L., Fischer, F. R., Raine, C. S. and Brosnan, C. F., CD1b is expressed in Multiple Sclerosis lesions. J. Neuroimmunol. 1996. 67: 145-51.
9. - T cells. J. Exp. Med. 1994. 180: 1171-6.
10. Valitutti, S., Muller, S., Cella, M., Padovan, E. and Lanzavecchia, A., Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 1995. 375: 148-51.
11. Chan, A. C., Desai, D. M. and Weiss, A., The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Annu. Rev. Immunol. 1994. 12: 555-92.
12. Steinman, L., Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 1996. 85: 299-302.
13. Mokhtarian, F., McFarlin, D. E. and Raine, C. S., Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice. Nature 1984. 309: 356-8.
14. Acarin, N., Rio, J., Fernandez, A. L., Tintore, M., Duran, I., Galan, I. and Montalban, X., Different anti-ganglioside antibody pattern between relapsing-remitting and progressive multiple sclerosis. Acta Neurol. Scand. 1996. 93: 99-103.
15. Bansal, A. S., Abdul-Karim, B., Malik, R. A., Goulding, P., Pumphrey, R. S., Boulton, A. J., Holt, P. L. and Wilson, P. B., IgM ganglioside GM1 antibodies in patients with autoimmune disease or neuropathy, and controls. J. Clin. Pathol. 1994. 47: 300-2.
16. Stevens, A., Weller, M. and Wietholter, H., CSP and serum ganglioside antibody patterns in MS. Acta Neurol. Scand. 1992. 86: 485-9.
17. Lubetzki, C., Thuillier, Y., Galli, A., Lyon-Caen, O., Lhermitte, F. and Zalc, B., Galactosylceramide: a reliable serum index of demyelination in multiple sclerosis. Ann. Neurol. 1989. 26: 407-9.
18. Sela, B. A., Konat, G. and Offner, H., Elevated ganglioside concentration in serum and peripheral blood lymphocytes from multiple sclerosis patients in remission. J. Neurol. Sci. 1982. 54: 143-8.
19. Brenner, M. and Porcelli, S., Antigen presentation: a balanced diet. Science 1997. 277: 332.
20. Zeng, Z., Castano, A. R., Segelke, B. W., Stura, E. A., Peterson, P. A. and Wilson, I. A., Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove. Science 1997. 277: 339-45.
21. Moody, D. B., Reinhold, B. B., Guy, M. R., Beckman, E. M., Frederique, D. E., Furlong, S. T., Ye, S., Reinhold, V. N., Sieling, P. A., Modlin, R. L., Besra, G. S. and Porcelli, S. A., Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells. Science 1997. 278: 283-6.
22. Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Motoki, K., Ueno, H., Nakagawa, R., Sato, H., Kondo, E., Koseki, H. and Taniguchi, M., CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides. Sciences 1997. 278: 1626-9.
23. Saito, M. and Yu, R. K., Glycolipids of the CNS. In Russel, W. C. (Ed.) Molecular Biology of Multiple Sclerosis. John Wiley & Sons, Ltd., New York 1997, p. 219-229.
24. Steck, A. J. and Kappos, L., Changing concepts in inflammatory and paraneoplastic neuropathies. Current Neurology 1996. 16: 191-212.
25. Ropper, A. H. and Gorson, K. C., Neuropathies Associated with Paraproteinemia. N. Engl. J. Med. 1998. 338: 1601-7.
26. Wilson, S. B., Kent, S. C., Patton, K. T., Orban, T., Jackson, R. A., Exley, M., Porcelli, S., Schatz, D. A., Atkinson, M. A., Balk, S. P., Strominger, J. L. and Hafler, D. A., Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes. Nature 1998. 391: 177-81.
27. Bürk, M. R., Carena, I., Donda, A., Mariani, F., Mori, L. and De Libero, G., Functional inactivation in the whole population of human Vγ9/Vδ2 T lymphocytes induced by a nonpeptidic antagonist. J. Exp. Med. 1997. 185: 91-7.
28. De Libero, G., Methods for generation of T cell clones and epithelial cell lines from excised human biopsies or needle aspirates. In Fernandez, N. and Butcher, G. (Eds.) MHC. A practical approach. IRL, Oxford 1997, p. 123-140.
29. Dreyfus, H., Guerold, B., Freysz, L. and Hicks, D., Successive isolation and separation of the major lipid fractions including gangliosides from single biological samples. Anal. Biochem. 1997. 249: 67-78.
30. Sallusto, F. and Lanzavecchia, A., Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 1994. 179: 1109-18.
31. McCutcheon, M., Wehner, N., Wensky, A., Kushner, M., Doan, S., Hsiao, L., Calabresi, P., Ha, T., Tran, T. V., Tate, K. M., Winkelhake, J. and Spack, E. G., A sensitive ELISPOT assay to detect low-frequency human T lymphocytes. J. Immunol. Methods 1997. 210: 149-66.
32. Andersson, U., Andersson, J., Lindfors, A., Wagner, K., Moller, G. and Heusser, C. H., Simultaneous production of interleukin 2, interleukin 4 and interferon-gamma by activated human blood lymphocytes. Eur. J. Immunol. 1990. 20: 1591-6.
33. Carena, I., Shamshiev, A., Donda, A., Colonna, M. and De Libero, G. D., Major histocompatibility complex class I molecules modulate activation threshold and early signaling of T cell antigen receptor-g/d stimulated by nonpeptidic ligands. J. Exp. Med. 1997. 186: 1769-74.