In vivo IL-4 responses to anti-IgD antibody are MHC class II dependent and β2-microglobulin independent and develop normally in the absence of IL- 4 priming of T cells

Journal of Immunology

Volumn 160, Issue 7, 1998, Pages 3299-3304

  Morris, Suzanne C ^a,b   Coffman, Robert L ^c   Finkelman, Fred D ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; IMMUNOGLOBULIN D ANTIBODY; IMMUNOGLOBULIN E; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGENICITY; ARTICLE; IMMUNOGLOBULIN PRODUCTION; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN SYNTHESIS REGULATION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL; BETA 2-MICROGLOBULIN; GOATS; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INJECTIONS, INTRAVENOUS; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, NUDE; MICE, TRANSGENIC; STAT6 TRANSCRIPTION FACTOR; T-LYMPHOCYTES; TRANS-ACTIVATORS;

EID: 0032055195     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Finkelman, F. D., J. Holmes, I. M. Katona, J. F. Urban, M. P. Beckmann, L. S. Park, K. A. Schooley, R. L. Coffman, T. R. Mosmann, and W. E. Paul. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8:303.
2. Finkelman, F. D., T. Shea-Donohue, J. Goldhill, C. A. Sullivan, S. C. Morris, K. B. Madden, W. C. Cause, and J. F. Urban, Jr. 1997. Cytokine regulation of host defense against parasitic gastrointestinal helminths: lessons from studies with rodent models. Annu. Rev. Immunol. 15:505.
3. Maggi, E., and S. Romagnani. 1994. Role of T cells and T-cell-derived cytokines in the pathogenesis of allergic diseases. Ann. NY Acad. Sci. 725:2.
4. Corry, D. B., H. G. Folkesson, M. L Warnock, D. J. Erle, M. A. Matthay, J. P. Wiener-Kronish, and R. M. Locksley. 1996. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 183:109.
5. LeGros, G., S. Z. Ben-Sasson, R. Seder, F. D. Finkelman, and W. E. Paul. 1990. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172:921.
6. Ben-Sasson, S. Z., G. Le Gros, D. H. Conrad, F. D. Finkelman, and W. E. Paul. 1990. Cross-linking Fc receptors stimulate splenic non-B, non-T cells to secrete IL-4 and other lymphokines. Proc. Natl. Acad. Sci. USA 87:1421.
7. Seder, R. A., W. E. Paul, A. M. Dvorak, S. J. Sharkis, A. Kagey-Sobotka, Y. Niv, F. D. Finkelman, S. A. Barbieri, S. J. Galli, and M. Plaut. 1991. Mouse splenic and bone marrow cell populations that express high affinity Feε receptors and produce IL-4 are highly enriched in basophils. Proc. Natl. Acad. Sci. USA 88:2835.
8. Sabin, E. A., M. A. Kopf, and E. J. Pearce. 1996. Schistosoma mansoni egg-induced early IL-4 production is dependent upon IL-5 and eosinophils. J. Exp. Med. 184:1871.
9. + T cell subsets: a subset (Thy0) that secretes diverse cytokines and overexpresses the Vβ8 T cell receptor gene family. J. Exp. Med. 176:269.
10. Yoshimoto, T., and W. E. Paul. 1994. CD4pos NK1.1pos T cells promptly produced IL-4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179:1285.
11. Bendelac, A., M. N. Rivera, S.-H. Park, and J. H. Roark. 1997. Mouse CD1-specific NK1 T cells: Development, specificity and function. Annu. Rev. Immunol. 15:535.
12. + T cells by CD1-expressing cortical thymocytes. J. Exp. Med. 182:2091.
13. + thymocytes selected by MHC class I molecules. Science 263:1774.
14. + thymocytes. J. Exp. Med. 180:395.
15. Smiley, S. T., M. H. Kaplan, and M. J. Grusby. 1997. Immunoglobulin E production in the absence of interleukin-4-secreting cD1-dependent cells. Science 275:977.
16. + T cell development and early IL-4 production in CD1-deficient mice. Immunity 6:459.
17. Mendiratta, S. K., W. D. Martin, S. Hong, A. Boesteanu, S. Joyce, and L. V. Kaer. 1997. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6:469.
18. + T cells in a TH2 response and in immunoglobulin E production. Science 270:1845.
19. 2-microglobulin dependent surface expression of functional mouse CD1.1. J. Exp. Med. 182:1913.
20. Morris, S. C., A. Lees, J. Inman, and F. D. Finkelman. 1992. Role of antigen-specific T cell help in the generation of in vivo antibody responses. I. Antigen-specific T cell help is required to generate a polyclonal IgG1 response in anti-IgD antibody-injected mice. J. Immunol. 149:3836.
21. Finkelman, F. D., I. Scher, J. J. Mond, S. Kessler, J. T. Kung and E. S. Metcalf. 1982. Poiyclonal activation of the murine immune system by an antibody to IgD. II. Generation of polyclonal antibody production and cells with surface IgG. J. Immunol. 129:638.
22. Morris, S. C., A. Lees, J. Holmes, R. Jeffries, and F. D. Finkelman. 1994. Induction of B cell and T cell tolerance in vivo by anti-CD23 mAb. J. Immunol. 152:3768.
23. + T cells are not essential for T helper cell 2 immune responses. J. Exp. Med. 184:1295.
24. 2-microglobulin-deficient BALB/c mice. J. Exp. Med. 183:484.
25. - T cell population. J. Immunol. 157:4421.
26. 2-microglobulin-containing neonatal intestinal transport receptor. Proc. Natl. Acad. Sci. USA 93:5512.
27. 2-microglobulin-deficient mice. Eur. J. Immunol. 26:690.
28. Finkelman, F. D., J. Smith, N. Villacreses and E. S. Metcalf. 1984. Polyclonal activation of the murine immune system by an antibody to IgD. VII. Demonstration of the role of non-antigen specific T help in in vivo B cell activation. J. Immunol. 133:550.
29. + T cells Science 248:1227.
30. + T cells in major histocompatibility complex class II-deficient mice. Science 253:1417.
31. Shimoda, K., J. van Deursen, M. Y. Sangster, S. R. Sarawar, R. T. Carson, R. A. Tripp, C. Chu, R. W. Quelle, T. Nosaka, D. A. Vignali, P. C. Doherty, G. Grosveld, W. E. Paul, and J. N. Ihle. 1996. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380:630.
32. Finkelman, F. D., S. W. Kessler, J. F. Mushinski and M. Potter. 1981. IgD secreting murine plasmacytomas: identification and characterization of two IgD myeloma proteins. J. Immunol. 126:680.
33. Zitron, I. M., D. E. Mosier, and W. E. Paul. 1977. The role of surface IgD in the response to thymic-independent antigens. J. Exp. Med. 146:1707.
34. Goroff, D. K., A. Stall, J. J. Mond, and F. D. Finkelman. 1986. In vitro and in vivo B lymphocyte activating properties of monoclonal anti-δ antibodies. I. Determinants of B lymphocyte activating properties. J. Immunol. 135:2382.
35. Finkelman, F. D., C. M. Snapper, J. D. Mountz and I. M. Katona. 1987. Polyclonal activation of the murine immune system by a goat antibody to mouse IgD. IX. Induction of a polyclonal IgE response. J. Immunol. 138:2826.
36. Abrams, J. S., M. G. Roncarolo, H. Yssel, U. Anderson, G. J. Gleich, and J. Silver. 1992. Strategies of anti-cytokine monoclonal antibody development. Immunol. Rev. 127:5.
37. Leo, O., M. Roo, D. Sachs, L. Samelson, and J. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA 84:1374.
38. Baniyash, M., and Z. Eshhar. 1984. Inhibition of IgE binding to mast cells and basophils by monoclonal antibodies to murine IgE. Eur. J. Immunol. 14:799.
39. Kehry, M. R., and L. C. Yamashita. 1989. Low affinity IgE receptor (CD23) function on mouse B cells: role of IgE-dependent antigen focusing. Proc. Natl. Acad. Sci. USA 86:7556.
40. Kaplan, M. H., U. Schindler, S. T. Smiley, and M. J. Grusby. 1996. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4:313.
41. Finkelman, F. D., J. Ohara, D. K. Goroff, J. Smith, N. Villacreses, J. J. Mond, and W. E. Paul. 1986. Production of BSF-1 during an in vivo, T-dependent immune response. J. Immunol. 137:2878.
42. Svetic, A., F. D. Finkelman, Y. C. Jian, C. W. Dieffenbach, D. E. Scott, K. F. McCarthy, A. D. Steinberg, and W. C. Gause. 1991. Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody. J. Immunol. 147:2391.
43. Takeda, K., T. K. Tanaka, W. Shi, M. Matsumoto, M. Minami, S. Kashiwamura, K. Nakanishi, N. Yoshida, T. Kishimoto, and S. Akira. 1996. Essential role of Stat6 in IL-4 signalling. Nature 380:627.
44. Scott, D. E., W. C. Gause, F. D. Finkelman, and A. D. Steinberg. 1990. Anti-CD3 antibody induces rapid expression of cytokine genes in vivo. J. Immunol. 145:2183.
45. + T cell IL-4 production is revealed by interleukin-4 receptor-deficient mice. Proc. Natl. Acad. Sci. USA. 94:10838.
46. Finkelman, F. D., I. Scher, J. J. Mond, J. T. Kung, and E. S. Metcalf. 1982. Polyclonal activation of the murine immune system by an antibody to IgD. I. Increase in cell size and DNA synthesis. J. Immunol. 129:629.
47. Morris, S. C., A. Lees, and F. D. Finkelman,. 1994. In vivo activation of naive T cells by antigen-presenting B cells. J. Immunol. 152:3777.
48. Mond, J. J., E. Sehgal, J. Kung, and F. D. Finkelman. 1981. Increased expression of I-region-associaled antigen (Ia) on B cells after cross-linking of surface immunoglobulin. J. Immunol. 127:881.
49. Lu, P., X. di Zhou, S.-J. Chen, M. Moorman, A. Schoneveld, S. Morris, F. D. Finkelman, P. Linsley, E. Classen, and W. C. Gause. 1995. Requirement for CTLA-4 counter receptors for IL-4 but not IL-10 elevations during a primary systemic in vivo immune response. J. Immunol. 154:1078.
50. + T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type. J. Exp. Med. 181:1081.
51. Finkelman, F. D., A. Svetic, I. Gresser, C. Snapper, J. Holmes, P. P. Trotta, I. M. Katona, and W. C. Gause. 1991. Regulation by interferon-α of immunoglobulin isotype selection and lymphokine production in mice. J. Exp. Med. 174: 1179.
52. Brunda, M. J. 1994. Interleukin-12. J. Leukocyte Biol. 55:280.
53. Germann, T., and E. Rude. 1995. Interleukin-12. Int. Arch. Allergy Immunol. 108:103.
54. Trinchieri, G., and F. Gerosa. 1996. Immunoregulation by interleukin-12. J. Leukocyte Biol. 59:505.