β2-Microglobulin-Deficient Mice Are Protected from Hypergammaglobulinemia and Have Defective Antibody Responses because of Increased IgG Catabolism

Journal of Immunology

Volumn 159, Issue 10, 1997, Pages 4781-4792

  Christianson, Gregory J ^a   Brooks, Warren ^a   Vekasi, Sarah ^a   Manolfi, Elizabeth A ^b   Niles, Jessica ^a   Roopenian, Shari L ^a   Roths, John B ^b   Rothlein, Robert ^c   Roopenian, Derry C ^a  

^a JACKSON LABORATORY   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; BETA 2 MICROGLOBULIN; DNP FICOLL; DNP-FICOLL; DRUG DERIVATIVE; FICOLL; GAMMA INTERFERON; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; IMMUNOGLOBULIN; INTERLEUKIN 4; LYMPHOCYTE ANTIGEN RECEPTOR; TAP1 PROTEIN, HUMAN; TAP1 PROTEIN, MOUSE; THYMUS INDEPENDENT ANTIGEN;

AGING; ANIMAL; ARTICLE; BIOSYNTHESIS; BLOOD; C3H MOUSE; C57BL MOUSE; CD8+ T LYMPHOCYTE; DISEASE PREDISPOSITION; FEMALE; FETOMATERNAL TRANSFUSION; GENETICS; HALF LIFE TIME; HYPERGAMMAGLOBULINEMIA; IMMUNOGLOBULIN G DEFICIENCY; IMMUNOLOGY; MOUSE; MURPHY ROTHS LARGE LYMPHOPROLIFERATIVE MOUSE; NATURAL KILLER CELL; NEW ZEALAND BLACK MOUSE; NONOBESE DIABETIC MOUSE; PHYSIOLOGY; PREGNANCY; SPECIES DIFFERENCE; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE SUBPOPULATION;

AGING; ANIMALS; ANTIGENS, T-INDEPENDENT; ATP-BINDING CASSETTE TRANSPORTERS; BETA 2-MICROGLOBULIN; CD8-POSITIVE T-LYMPHOCYTES; DISEASE SUSCEPTIBILITY; FEMALE; FICOLL; HALF-LIFE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; HYPERGAMMAGLOBULINEMIA; IGG DEFICIENCY; IMMUNOGLOBULINS; INTERFERON TYPE II; INTERLEUKIN-4; KILLER CELLS, NATURAL; LUPUS ERYTHEMATOSUS, SYSTEMIC; MATERNAL-FETAL EXCHANGE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED MRL LPR; MICE, INBRED NOD; MICE, INBRED NZB; PREGNANCY; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SPECIES SPECIFICITY; T-LYMPHOCYTE SUBSETS;

EID: 0031573205     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Mossman, T. R., and S. Sad. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17:138.
2. + T cells secreting Th1 and Th2 cytokines. Immunity 2:271.
3. + thymocytes selected by MHC class I molecules. Science 263:1774.
4. + thymocytes. J. Exp. Med. 180:395.
5. + T cells in a Th2 response and immunoglobulin E production. Science 270:1845.
6. Liao, N. S., M. Bix, M. Zijlstra, R. Jaenisch, and D. Raulet. 1991. MHC class I deficiency: susceptibility to natural killer (NK) cells and impaired NK activity. Science 253:199.
7. Mond, J. J., Q. Vos, A. Lees, and C. M. Snapper. 1995. T cell independent antigens. Curr. Opin. Immunol. 7:349.
8. Ahouse, J. J., C. L. Hagerman, P. Mittal, D. J. Gilbert, N. G. Copeland, N. A. Jenkins, and N. E. Simister. 1993. Mouse MHC class I-like Fc receptor encoded outside the MHC. J. Immunol. 151:6076.
9. Story, C. M., J. E. Mikulska, and N. H. Simister. 1994. A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus. J. Exp. Med. 180:2377.
10. Israel, E. J., V. K. Patel, S. F. Taylor, A. Marshak-Rothstein, and N. H. Simister. 1995. Requirement for a beta 2-microglobulin-associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice. J. Immunol. 154:6246.
11. 2-microglobulin deficient mice. Eur. J. Immunol. 26:690.
12. 2-microglobulin-containing neo-intestinal transport receptor (FcRn). Proc. Natl. Acad. Sci. USA 93:5512.
13. Simister, N. E., and K. E. Mostov. 1989. An Fc receptor structurally related to MHC class I antigens. Nature 337:184.
14. + cytolytic T cells. Nature 344:742.
15. Simister, N. E., C. M. Story, H. L. Chen, and J. S. Hunt. 1996. An IgG-transporting Fc receptor expressed in the syncytiotrophoblast of human placenta. Eur. J. Immunol. 26:1527.
16. Leach, J. L., D. D. Sedmak, J. M. Osborne, B. Rahill, M. D. Larimore, and C. L. Anderson. 1996. Isolation from human placenta of the IgG transporter. FcRn, and localization to the sycnytiotrophoblast. J. Immunol. 157:3317.
17. Israel, E. J., D. F. Wilsker, K. C. Hayes, D. Schoenfeld, and N. E. Simister. 1996. Increased clearance of IgG in mice that lack beta 2-microglobulin: possible protective role of FcRn. Immunology 89:573.
18. 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proc. Natl. Acad. Sci. USA 86:8932.
19. + T cells. Science 248:1227.
20. + T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses. Proc. Natl. Acad. Sci. USA 89:6070.
21. 2-microglobulin. J. Immunol. 154:2063.
22. Maldonado, M. A., R. A. Eisenberg, E. Roper, P. L. Cohen, and B. L. Kotzin. 1995. Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I. J. Exp. Med. 181:641.
23. 2 microglobulin dependence of lupus-like autoimmune syndrome of MRL-lpr mice. J. Immunol. 176:4933.
24. Moses, E., L. D. Kohn, F. Hakim, and D. S. Singer. 1993. Resistance of MHC class-I deficient mice to experimental systemic lupus erythematosus. Science 261:91.
25. Ghiasi, H., D. C. Roopenian, S. Slanina, S. Cai, A. B. Nesburn, and S. L. Wechsler. 1997. The role of MHC-I and MHC-II in protection of naive and vaccinated mice following lethal HSV-1 challenge. Immunology. 91:430.
26. Gosgrove, D., D. Gray, A. Dierich, J. Kaufman, M. Lemeur, C. Benoist, and D. Mathis. 1991. Mice lacking MHC class II molecules. Cell 66:1051.
27. Kuhn, R., K. Rajewsky, and W. Muller. 1991. Generation and analysis of interleukin-4 deficient mice. Science 254:707.
28. Dalton, D. K., S. Pitts-Meek, S. Keshav, I. S. Figari, A. Bradley, and T. A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science 259:1739.
29. Mombaerts, P., A. R. Clarke, M. A. Rudnicki, J. Lacomini, S. Itohara, J. J. Lafaille, L. Wang, Y. Ichikawa, R. Jaenisch, M. L. Hooper, and S. Tonegawa. 1992. Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages. Nature 360:225.
30. Cobbold, S. P., A. Jayasuriya, A. Nash, T. D. Prospero, and H. Waldmann. 1984. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 312:548.
31. Koo, G. C., and J. R. Peppard. 1984. Establishment of monoclonal anti-NK-1.1 antibody. Hybridoma 3:301.
32. Christianson, S. W., D. L. Greiner, I. B. Schweitzer, B. Gott, G. L. Beamer, P. A. Schweitzer, R. M. Hesselton, and L. D. Shultz. 1996. Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL6J-scid bg mice. Cell. Immunol. 171:186.
33. 2-microglobulin-deficient NON-scid mice. J. Immunol. 158:3578.
34. Sentman, C. C., J. Hackett, T. A. Moore, M. M. Tutt, M. Bennett, V. Kumar. 1989. Pan natural killer cell monoclonal antibodies and their relationship to the NK1.1 antigen. Hybridoma 8:605.
35. Theofilopolis, A. N., and F. J. Dixon. 1981. Etiopathogenesis of murine SLE. Immunol. Rev. 55:179.
36. Theofilopolus, A. N., and F. J. Dixon. 1985. Murine models of systemic lupus erythematosus. Adv. Immunol. 37:296.
37. Murphy, E. D., and J. B. Roths. 1979. A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum. 22:1188.
38. Murphy, E. D., and J. B. Roths. 1978. Autoimmunity and lymphoproliferation: induction by mutant gene lpr, and acceleration by a male-associated factor in strain BXSB mice. In Genetic Control of Autoimmune Disease, eds. Rose, Bigazzi, and Warner, eds. Elsevier/North Holland, Amsterdam, pp. 207-221.
39. + T cell. Cell 71:1205.
40. + T cells that promptly produce interleukin 4. Proc. Natl. Acad. Sci. USA 92:11931.
41. Kaminsky, S. G., I. Nakamura, and G. Cudkowicz. 1983. Selective defect of natural killer and killer cell activity against lymphomas in SJL mice: low responsiveness to interferon inducers. J. Immunol. 130:1980.
42. Serreze, D. V., and E. H. Leiter. 1988. Defective activation of T suppressor cell function in nonobese diabetic mice: potential relation to cytokine deficiencies. J. Immunol. 140:3801.
43. - T cells. Diabetes 46:572.
44. Mond, J. J., A. Lees, and C. M. Snapper. 1995. T cell-independent antigens type 2. Annu. Rev. Immunol. 13:655.
45. Markowitz, J. S., P. R. Rogers, M. J. Grusby, D. C. Parker, and L. H. Glimcher. 1993. B lymphocyte development and activation independent of MHC class II expression. J. Immunol. 150:1223.
46. Mombaerts, P., J. Iacomini, R. S. Johnson, K. Herrup, S. Tonegawa, and V. E. Papaioannou. 1992. RAG-1 deficient mice have no mature B and T lymphocytes. Cell 68:869.
47. Fung Leung, W. P., M. W. Schilham, A. Rahemtulla, T. M. Kundig, M. Vollenweider, J. Potter, W. van Ewijk, and T. W. Mak. 1991. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 65:443.
48. + T cells. Curr. Biol. 7:367.
49. + T cells: a new family of T cells. Immunol. Today 17:71.
50. +) T cells that express αβ T cell receptors in transporters associated with antigen presentation: null and thymus leukemia antigen positive mice. J. Exp. Med. 184:1579.
51. Yoshimoto, T., and W. E. Paul. 1994. CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179:1285.
52. Wilder, J. A., C. Y. Koh, and D. Yuan. 1996. The role of NK cells during in vivo antigen-specific antibody responses. J. Immunol. 156:146.
53. Brambell, F. W. R., W. A. Hemmings, and I. G. Morris. 1964. A theoretical model of γ-globulin catabolism. Nature 203:1352.
54. Blumberg, R. S., T. Koss, C. M. Story, D. Barisani, J. Polischuk, A. Lipin, L. Pablo, R. Green, and N. E. Simister. 1995. A major histocompatibility complex class I-related Fc receptor for IgG on rat hepatocytes. J. Clin. Invest. 95:2397.
55. 2 Microglobulin-deficient mice are resistant to bullous pemphigoid. J. Exp. Med. 180:777.
56. Wicker, L. S., E. H. Leiter, J. A. Todd, R. J. Renjilian, E. Peterson, P. A. Fischer, P. L. Podolin, M. Zijlstra, R. Jaenisch, and L. B. Peterson. 1994. Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes. Diabetes 43: 500.
57. null mice are diabetes and insulitis resistant. Diabetes 43:505.
58. null mice. J. Exp. Med. 184:2149.
59. Morel, L., C. Mohan, Y. Yu, B. P. Croker, N. Tian, A. Deng, and E. K. Wakeland. 1997. Functional dissection of systemic lupus erythematosus using congenic mouse strains. J. Immunol. 158:6019.
60. Morel, L., U. H. Rudofsky, J. A. Longmate, J. Schiffenbauer, and E. K. Wakeland. 1994. Polygenic control of susceptibility to murine systemic lupus erythematosus. Immunity 1:219.
61. Watson, M. L., J. K. Rao, G. S. Gilkeson, P. Ruiz, E. M. Eicher, D. S. Pisetsky, A. Matsuzawa, J. M. Rochelle, and M. F. Seldin. 1992. Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J. Exp. Med. 176:1645.