-
8
-
-
0028952805
-
Inhibitory cross-talk between steroid hormone receptors: Differential targeting of estrogen receptor in the repression of its transcriptional activity in agonist-and antagonist-occupied progestin receptors
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 1847-1857
-
-
Kraus, W.L.1
Weis, K.E.2
Katzenellenbogen, B.S.3
-
9
-
-
0029685663
-
AROMe
-
Progress in Medicinal Chemistry. Ellis GP, Luscombe DK (Eds.), Elsevier Science, Amsterdam
-
(1996)
, vol.33
, pp. 147-184
-
-
Banting, L.1
-
10
-
-
0002500198
-
The irreversible inhibition of aromatase (oestrogen synthetase) by steroidal compounds
-
(1995)
Curr. Pharm. Des.
, vol.1
, pp. 23-50
-
-
Lombardi, P.1
-
11
-
-
0024793429
-
Recent developments in aromatase inhibition as a potential treatment for oestrogen-dependent breast cancer
-
Progress in Medicinal Chemistry. Ellis GP, West GB (Eds.), Elsevier, Amsterdam
-
(1989)
, vol.26
, pp. 253-298
-
-
Banting, L.1
Nicholls, P.J.2
Shaw, M.A.3
Smith, H.J.4
-
15
-
-
4243285935
-
Aromatase inhibitors and breast cancer
-
Hormones and Cancer. Vedeckis WV (Ed.), Birkhauser, Boston, USA
-
(1996)
-
-
Brodie, A.M.H.1
-
25
-
-
0004977205
-
From programme sanction to clinical trials: A partial view of the quest for Arimidex™, a potent selective inhibitor of aromatase
-
Introduction to the Principles of Drug Design and Action. Smith HJ (Ed.), Harwood Academic Publishers, Amsterdam
-
(1998)
, vol.3
, pp. 208-235
-
-
Edwards, P.N.1
-
26
-
-
0004951574
-
Enzyme inhibitors as drugs: From design to the clinic
-
Design of Enzyme Inhibitors as Drugs. Sandler M, Smith HJ (Eds.), OUP, Oxford
-
(1988)
, vol.2
, pp. 1-41
-
-
Luscombe, D.K.1
Tucker, M.2
Pepper, C.J.3
-
29
-
-
0032907539
-
The third-generation non-steroidal aromatase inhibitors: A review of their clinical benefits in the second-line hormonal treatment of advanced breast cancer
-
(1999)
Annal. Oncol.
, vol.10
, pp. 377-384
-
-
Hamilton, A.1
Piccart, M.2
-
30
-
-
0032979982
-
Synthesis and structure-activity relationships of 6-phenylaliphatic-substituted C-19 steroids having a 1,4-diene, 4,6-diene or 1,4,6-triene structure as aromatase inhibitors
-
(1999)
Steroids
, vol.64
, pp. 187-196
-
-
Numazawa, M.1
Yamaguchi, S.2
-
40
-
-
0022536513
-
Stimulation of cell proliferation and estrogenic response by adrenal C19-delta-5-steroids in the ZR-75-1 human breast cancer cell line
-
(1986)
Cancer Res.
, vol.46
, pp. 4933-4937
-
-
Poulin, R.1
Labrie, F.2
-
41
-
-
0001686506
-
Immunological consequences of inhibiting dehydroepiandrosterone sulfatase in vivo
-
In Steroid Hormones and the T-cell Cytokine Profile. (Rook GAW, Lightman S (Eds.), Springer, Berlin, Germany
-
(1997)
, pp. 135-152
-
-
Foulkes, R.1
Shaw, S.2
Suitters, A.3
-
45
-
-
0022834826
-
Human placental steryl sulfatase: Enzyme purification, production of antisera and immunoblotting reactions with normal and sulfatase-deficient patients
-
(1986)
Biol. Chem. Hoppe-Seyler
, vol.367
, pp. 1223-1229
-
-
Dibbelt, L.1
Kuss, E.2
-
48
-
-
0032539976
-
Crystal structure of human arylsulfatase A: The aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis
-
(1998)
Biochemistry
, vol.37
, pp. 3654-3664
-
-
Lukatela, G.1
Krauss, N.2
Theis, K.3
-
56
-
-
0032555172
-
17α-Alkyl- or 17α-substituted benzyl-17β-estradiols: A new family of oestrone sulphatase inhibitors
-
Boivin representative
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 1891-1896
-
-
Poirier, D.1
-
63
-
-
0032974115
-
Status of aromatase inhibitors in relation to other breast cancer treatment modalities
-
(1999)
Endocr. Rel. Cancer
, vol.6
, pp. 277-291
-
-
Ragaz, J.1
-
68
-
-
0024361957
-
Characterisation of cDNAs for human estradiol 17β-dehydrogenase and assignment of the gene to chromosome 17: Evidence of two mRNA species with distinct 5′ termini in human placenta
-
(1989)
Mol. Endocrinol.
, vol.3
, pp. 1301-1309
-
-
Luu-The, V.1
Labrie, C.2
Zhao, H.F.3
-
76
-
-
0025166516
-
A possible mechanism for increased breast cell-proliferation by progestins through increased reductive 17β-hydroxysteroid dehydrogenase activity
-
(1990)
Int. J. Cancer
, vol.45
, pp. 174-178
-
-
Coldham, N.G.1
James, V.H.T.2
-
92
-
-
0030272290
-
Synthesis and evaluation of oestradiol derivatives with 16α-(bromoalkylamide), 16α-(bromoalkyl) or 16α-(bromoalkynyl) side chain as inhibitor of 17β-hydroxysteroid dehydrogenase Type 1 without estrogenic activity
-
(1996)
Bioorg. Med. Chem.
, vol.4
, pp. 1617-1628
-
-
Pelletier, J.D.1
Poirier, D.2
-
99
-
-
0027283967
-
Genistein is an effective stimulator of sex hormone-binding globulin production in hepatocarcinoma human liver cancer cells and suppresses proliferation of these cells in culture
-
(1993)
Steroids
, vol.58
, pp. 301-304
-
-
Mousavi, Y.1
Adlercreutz, H.2
-
105
-
-
0033966934
-
Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17β-hydroxysteroid dehydrogenase- C-18/C-19 steroid discrimination and enzyme-induced strain
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 1105-1111
-
-
Han, Q.1
Campbell, R.L.2
Gangloff, A.3
-
109
-
-
0015375422
-
Carcinoma of the prostate: Prognostic evaluation of certain pathologic features in 208 radical prostatectomies. Examined by the step-section technique
-
(1972)
Cancer
, vol.30
, pp. 5-13
-
-
Byar, D.P.1
Mostofi, F.K.2
-
111
-
-
0025869392
-
Prostate specific antigen: A critical assessment of the most useful tumor marker for adenocarcinoma of the prostate
-
(1991)
J. Urol.
, vol.145
, pp. 907-923
-
-
Oesterling, J.E.1
-
114
-
-
0028880521
-
Androgen deprivation with radiation-therapy compared with radiation-therapy alone for locally advanced prostatic-carcinoma - A randomized comparative trial of the radiation-therapy oncology group
-
(1995)
Urology
, vol.45
, pp. 616-623
-
-
Pilepich, M.V.1
Krall, J.M.2
Alsarraf, M.3
-
115
-
-
0023265144
-
New methods of endocrine management of prostatic cancer
-
(1987)
J. Urol.
, vol.137
, pp. 1-10
-
-
Smith J.A., Jr.1
-
116
-
-
15444355594
-
Discovery of a novel, potent and orally-active non-peptide antagonist of the human luteinizing hormone - Releasing hormone (LHRH) receptor
-
(1998)
J. Med. Chem.
, vol.41
, pp. 4190-4195
-
-
Cho, N.1
Harada, M.2
Imaeda, T.3
-
125
-
-
0028799960
-
Combination finasteride and flutamide in advanced carcinoma of the prostate - Effective therapy with minimal side-effects
-
(1995)
J. Urol.
, vol.154
, pp. 1642-1645
-
-
Fleshner, N.E.1
Trachenberg, J.2
-
131
-
-
0029937631
-
Mechanism-based inhibition of human steroid 5 alpha-reductase by finasteride: Enzyme-catalyzed formation of NADP-dihydrofinasteride, potent bisubstrate analog inhibitor
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 2359-2365
-
-
Bull, M.G.1
-
139
-
-
0026720615
-
The effect of finasteride in men with benign prostatic hyperplasia
-
(1992)
J. Urol.
, vol.147
, pp. 1298-1302
-
-
Stoner, E.1
-
141
-
-
0028049193
-
Maintenance of clinical efficacy with finasteride therapy for 24 months in patients with benign prostatic hyperplasia
-
(1994)
Arch. Intern. Med.
, vol.154
, pp. 83-88
-
-
Stoner, E.1
-
142
-
-
0029098816
-
4-aza-3-oxo-5-alpha-androst-1-ene-17-beta-N-aryl-carboxamides as dual inhibitors of human type-1 and type-2 steroid 5-alpha-reductase - Dramatic effect of N-aryl substituents on type-1 and type-2 5-alpha reductase inhibitory potency
-
(1995)
J. Med. Chem.
, vol.38
, pp. 3189-3192
-
-
Bakshi, R.K.1
Rasmusson, G.H.2
Patel, G.F.3
-
143
-
-
0028807269
-
Mechanism of time-dependent inhibition of 5-alpha-reductase by delta(1)-4-azasteroids - Towards perfection of rates of time-dependent inhibition by using ligand-binding energies
-
(1995)
Biochemistry
, vol.43
, pp. 13453-13459
-
-
Tian, G.C.1
Mook, R.A.2
Moss, M.L.3
-
146
-
-
18744424138
-
Structure-activity-relationships for inhibition of type-1 and type-2 human 5-alpha-reductase and human adrenal 3-beta-hydroxy-delta(5)-steroid dehydrogenase 3-keto-delta(5)-steroid isomerase by of the C17 substituent
-
(1995)
J. Med. Chem.
, vol.38
, pp. 2621-2627
-
-
Frye, S.V.1
Haffner, C.D.2
Maloney, P.R.3
-
150
-
-
0026723090
-
Tissue distribution and kinetic characteristics of rat steroid 5-alpha-reductase isozymes - Evidence for distinct physiological functions
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 19548-19554
-
-
Normington, K.1
Russell, D.W.2
-
162
-
-
0032919289
-
Finasteride -An update of its use in the management of symptomatic benign prostatic hyperplasia
-
(1999)
Drugs
, vol.57
, pp. 557-581
-
-
Wilde, M.I.1
Goa, K.L.2
-
164
-
-
0031744756
-
Long-term effects of finasteride in patients with benign prostatic hyperplasia: A double-blind, placebo-controlled, multicenter study
-
(1998)
Urology
, vol.51
, pp. 677-686
-
-
Marberger, M.J.1
-
171
-
-
0000169761
-
17a-Hydroxylase/ 17,20-lyase
-
Design of Enzyme Inhibitors as Drugs. Sandler M, Smith HJ (Eds.), Oxford University Press, Oxford
-
(1994)
, vol.2
, pp. 438-461
-
-
Vanden Bossche, H.1
Moereels, H.2
-
176
-
-
0023601787
-
Inhibition of testicular 17 alpha-hydroxylase and 17,20-lyase but not 3 beta-hydroxysteroid dehydrogenase-isomerase or 17 beta-hydroxysteroid oxidoreductase by ketoconazole and other imidazole drugs
-
(1987)
J. Steroid Biochem.
, vol.28
, pp. 521-531
-
-
Ayub, M.1
Levell, M.J.2
-
179
-
-
0004926494
-
Retinoic acid and cytochrome P-450
-
Retinoic acid: 10 Years On. Saurat J-H (Ed.), Karger, Basel, Switzerland
-
(1991)
, pp. 79-88
-
-
Vanden Bossche, H.1
Willemsens, G.2
-
182
-
-
15644378537
-
The emerging role of retinoids and retinoic acid metabolism blocking agents in the treatment of cancer
-
(1998)
Cancer
, vol.83
, pp. 1471-1482
-
-
Miller, W.H.1
-
184
-
-
0029918184
-
Metabolism of all-trans, 9-cis and 13-cis isomers of retinal by purified isozymes of microsomal cytochrome P-450 and mechanism-based inhibition of retinoid oxidation by citral
-
(1996)
Mol. Pharmacol.
, vol.49
, pp. 515-522
-
-
Raner, G.M.1
Vaz, A.D.2
Coon, M.J.3
-
199
-
-
0031928439
-
Novel non-steroidal inhibitors of cytochrome P450 (17α) (17α-hydroxylase/C17-20 lyase), YM 116, decreased prostatic weights by reducing serum concentrations of testosterone and adrenal androgens in rats
-
(1998)
Prostate
, vol.37
, pp. 10-18
-
-
Ideyama, Y.1
Kudoh, M.2
Tanimoto, K.3
-
204
-
-
0029763048
-
3- and 4-pyridylalkyl-adamantanecarboxylates: Inhibitors of human cytochrome P450 (17 alpha) (17 alpha-hydroxylase/C-17,C-20-lyase): Potential nonsteroidal agents for the treatment of prostatic cancer
-
(1996)
J. Med. Chem.
, vol.39
, pp. 3319-3323
-
-
Chan, F.C.Y.1
Potter, G.A.2
Barrie, S.E.3
-
210
-
-
0032585605
-
The 16,17-double bond is needed for irreversible inhibition of human cytochrome P450 (17 alpha) by abiraterone (17-(3-pyridyl)androsta-5,16-dien-3-beta-ol) and related steroidal inhibitors
-
(1998)
J. Med. Chem.
, vol.41
, pp. 5375-5381
-
-
Jarman, M.1
Barrie, S.E.2
Llera, J.M.3
-
211
-
-
0032510321
-
Novel 17-azoyl steroids, potent inhibitors of human cytochrome 17-alpha-hydroxylase-C-17, C-20-lyase (P450 (17 alpha)): Potential agents for the treatment of prostate cancer
-
(1998)
J. Med. Chem.
, vol.41
, pp. 902-912
-
-
Njar, V.C.O.1
Kato, K.2
Nnane, I.P.3
Grigoryev, D.N.4
Long, B.J.5
Brodie, A.M.H.6
|