Novel nonsteroidal inhibitor of cytochrome P450(17α) (17α- hydroxylase/C17-20 lyase), YM116, decreased prostatic weights by reducing serum concentrations of testosterone and adrenal androgens in rats

Prostate

Volumn 37, Issue 1, 1998, Pages 10-18

  Ideyama, Y ^a   Kudoh, M ^a   Tanimoto, K ^a   Susaki, Y ^a   Nanya, T ^a   Nakahara, T ^a   Ishikawa, H ^a   Yoden, T ^a   Okada, M ^a   Fujikura, T ^a   Akaza, H ^a   Shikama, H ^a  

^a Inst for Drug Discovery Research   (Japan)

Author keywords

Adrenal gland; CB7630; Ketoconazole; Leuprolide; Liarozole; Orchiectomy

Indexed keywords

2 (1H IMIDAZOL 4 YL METHYL) 9H CARBAZOLE; 2 (1H IMIDAZOL 4 YLMETHYL) 9H CARBAZOLE; ALDOSTERONE; ANDROGEN; BICALUTAMIDE; CYTOCHROME P450 INHIBITOR; ESTRADIOL; FLUTAMIDE; GONADORELIN; HYDROCORTISONE; KETOCONAZOLE; LEUPRORELIN; LIAROZOLE; PRASTERONE SULFATE; SERIC GONADOTROPIN; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE; TESTOSTERONE; TETRACOSACTIDE; UNCLASSIFIED DRUG;

ADRENAL GLAND; ALDOSTERONE BLOOD LEVEL; ANDROGEN BLOOD LEVEL; ANDROGEN SYNTHESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CASTRATION; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; FEMALE; GUINEA PIG; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; MICROSOME; NONHUMAN; ORAL DRUG ADMINISTRATION; ORCHIECTOMY; ORGAN WEIGHT; PRIORITY JOURNAL; PROSTATE; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TESTIS; TESTOSTERONE BLOOD LEVEL;

ADRENAL GLANDS; ADRENOCORTICOTROPIC HORMONE; ANDROGENS; ANDROSTADIENES; ANIMALS; CARBAZOLES; ENZYME INHIBITORS; GONADOTROPIN-RELEASING HORMONE; GUINEA PIGS; IMIDAZOLES; KETOCONAZOLE; MALE; ORCHIECTOMY; ORGAN SIZE; PROSTATE; RATS; SEMINAL VESICLES; STEROID 17-ALPHA-HYDROXYLASE; TESTOSTERONE;

EID: 0031928439     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0045(19980915)37:1<10::AID-PROS3>3.0.CO;2-C     Document Type: Article

References (34)