Breast tumor aromatase: Functional role and transcriptional regulation

Endocrine-Related Cancer

Volumn 6, Issue 2, 1999, Pages 149-156

  Chen, S ^a   Zhou, D ^a   Okubo, T ^a   Kao, Y C ^a   Yang, C ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; CELL NUCLEUS RECEPTOR; CYCLIC AMP; DNA; ESTROGEN; TRANSCRIPTION FACTOR;

ARTICLE; BREAST TUMOR; CYCLIC AMP RESPONSIVE ELEMENT; ENZYME ACTIVITY; ESTROGEN SYNTHESIS; FIBROBLAST; HUMAN; IMMUNOCYTOCHEMISTRY; NONHUMAN; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SILENCER GENE; STROMA CELL; TRANSCRIPTION REGULATION;

ANIMALS; AROMATASE; BREAST NEOPLASMS; CYCLIC AMP; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS, HORMONE-DEPENDENT; PROMOTER REGIONS (GENETICS); RECEPTORS, ESTROGEN; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0032977196     PISSN: 13510088     EISSN: None     Source Type: Journal    
DOI: 10.1677/erc.0.0060149     Document Type: Article

References (35)

1. Aronica SM, Kraus WL & Katzenellenbogen BS 1994 Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription. Proceedings of the National Academy of Sciences of the USA 91 8517-8521.
2. Bulun SE, Price TM, Mahendroo MS, Aitken J & Simpson ER 1993 A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription. Journal of Clinical Endocrinology and Metabolism 77 1622-1628.
3. Bulun SE, Noble LS, Takayama K, Michael MD, Agarwal V, Fisher C, Zhao Y, Hinshelwood MM, Ito Y & Simpson ER 1997 Endocrine disorders associated with inappropriately high aromatase expression. Journal of Steroid Biochemistry and Molecular Biology 61 133-139.
4. Burak Jr WE, Quinn AL, Farrar WB & Brueggemeier RW 1997 Androgens influence estrogen-induced responses in human breast carcinoma cells through cytochrome P450 aromatase. Breast Cancer Research and Treatment 44 57-64.
5. Esteban JM, Warsi Z, Haniu M, Hall PF, Shively JE & Chen S 1992 Detection of intratumoral aromatase in breast carcinomas, an immunohistochemical study with clinicopathologic correlation. Journal of American Pathology 140 337-343.
6. Harada N 1993 A unique aromatase (P-450arom) mRNA formed by alternative use of tissue-specific exons I in human skin fibroblasts. Biochemical and Biophysical Research Communications 189 1001-1007.
7. Harada N 1997 Aberrant expression of aromatase in breast cancer tissues. Journal of Steroid Biochemistry and Molecular Biology 61 175-184.
8. James VHT, McNeill JM, Lai LC, Newton CJ, Ghilchik MW & Reed MJ 1987 Aromatase activity in normal breast and breast tumor tissues: in vivo and in vitro studies. Steroids 50 269-279.
9. Kitawaki J, Fukuoka M, Yamamoto T, Honjo H & Okada H 1992 Contribution of aromatase to the deoxyribonucleic acid synthesis of MCF-7 human breast cancer cells and its suppression by aromatase inhibitors. Journal of Steroid Biochemistry and Molecular Biology 42 267-277.
10. Klinge CM, Silver BF, Driscoll MD, Sathya G, Bambara RA & Hilf R 1997 Chicken ovalbumin upstream promoter-transcription factor interacts with estrogen receptor, binds to estrogen response elements and half-sites, and inhibits estrogen-induced gene expression. Journal of Biological Chemistry 272 31465-31474.
11. Lu Q, Nakamura J, Savinov A, Yue W, Weisz J, Dabbs DJ, Wolz G & Brodie A 1996 Expression of aromatase protein and messenger ribonucleic acid in tumor epithelial cells and evidence of functional significance of locally produced estrogen in human breast cancers. Endocrinology 137 3061-3077.
12. Mahendroo MS, Mendelson CR & Simpson ER 1993 Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue. Journal of Biological Chemistry 268 19463-19470.
13. Michael MD, Kilgore MW, Morohashi KI & Simpson ER 1995 Ad4BP/SF-1 regulates cyclic AMP-induced transcription from the proximal promoter (PII) of the human aromatase P450 (CYP 19) gene in the ovary. Journal of Biological Chemistry 270 13561-13566.
14. Michael MD, Michael LF & Simpson ER 1997 A CRE-like sequence that binds CREB amd contributes to cAMP-dependent regulation of the proximal promoter of the human aromatase P450 (CYP 19) gene. Molecular and Cellular Endocrinology 134 147-156.
15. Miller WR & O'Neill J 1987 The importance of local synthesis of estrogen within the breast. Steroids 50 537-548.
16. Miller WR, Mullen P, Sourdaine P, Watson C, Dixon JM & Telford J 1997 Regulation of aromatase activity within the breast. Journal of Steroid Biochemistry and Molecular Biology 61 193-202.
17. Pasqualini JR, Chetrite G, Blacker C, Feinstein MC, De la Londe L, Talbi M & Maloche C 1996 Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre-and postmenopausal breast cancer patients. Journal of Clinical Endocrinology and Metabolism 81 1460-1464.
18. Santen RJ, Martel J, Hoagland M, Naftolin F, Roa L, Harada N, Hafer L, Zaino R & Santner SJ 1994 Stromal spindle cells contain aromatase in human breast tumors. Journal of Clinical Endocrinology and Metabolism 79 627-632.
19. Santner SJ, Chen S, Zhou D, Korsunsky Z, Martel J & Santen RJ 1993 Effect of androstenedione on growth of untransfected and aromatase-transfected MCF-7 cells in culture. Journal of Steroid Biochemistry and Molecular Biology 44 611-616.
20. Sasano H, Nagura H, Harada N, Goukon Y & Kimura M 1994 Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders. Human Pathology 25 530-535.
21. Shibata H, Nawaz Z, Tsai SY, O'Malley BW & Tsai MJ 1997 Gene silencing by chicken ovalbumin upstream promoter-transcription factor 1 (COUP-TF1) is mediated by transcriptional corepressors, nuclear receptor-corepressor (N-CoR) and silencing mediator for retinoic acid receptor and thyroid hormone receptor (SMRT). Molecular Endocrinology 11 714-724.
22. Shozu M, Zhao Y, Bulun SE & Simpson ER 1998 Multiple splicing events involved in regulation of human aromatase expression by a novel promoter, I.6. Endocrinology 139 1610-1617.
23. Sun XZ, Zhou D & Chen S 1997 Autocrine and paracrine actions of breast tumor aromatase. A three-dimensional cell culture study involving aromatase transfected MCF-7 and T-47D cells. Journal of Steroid Biochemistry and Molecular Biology 63 29-36.
24. Tada H, Shiho O, Kuroshima KI, Koyama M & Tsukamoto K 1986 An improved colorimetric assay for interleukin 2. Journal of Immunological Methods 93 157-165.
25. Tekmal RR, Ramachandra N, Gubba S, Durgam VR, Mantione J, Toda K, Shizuta Y & Dillehay DL 1996 Overexpression of int-5/aromatase in mammary glands of transgenic mice results in the induction of hyperplasia and nuclear abnormalities. Cancer Research 56 3180-3185.
26. Wang J & Chen S 1992 Identification of a promoter and a silencer at the 3'-end of the first intron of the human aromatase gene. Molecular Endocrinology 6 1479-1488.
27. Yang C, Zhou D & Chen S 1998 Modulation of aromatase expression in breast tissue by ERRα-1 orphan receptor. Cancer Research 58 5695-5700.
28. Yue W, Zhou, Chen S & Brodie A 1994 A new nude mouse model for postmenopausal breast cancer using MCF-7 cells transfected with the human aromatase gene. Cancer Research 54 5092-5095.
29. Zhao Y, Mendelson CR & Simpson ER 1955 Characterization of the sequences of the human CYP19 (aromatase) gene that mediate regulation by glucocorticoids in adipose stromal cells and fetal hepatocytes. Molecular Endocrinology 9 340-349.
30. Zhao Y, Agarwal VR, Mendelson CR & Simpson ER 1997 Transcriptional regulation of CYP19 gene (aromatase) expression in adipose stromal cells in primary culture. Journal of Steroid Biochemistry and Molecular Biology 61 203-210.
31. Zhou D & Chen S 1998 Characterization of a silencer element in the human aromatase gene. Archives of Biochemistry and Biophysics 353 213-220.
32. Zhou D, Pompon D & Chen S 1990 Stable expression of human aromatase cDNA in mammalian cells - a useful system for aromatase inhibitor screening. Cancer Research 50 6949-6954.
33. Zhou D, Wang J, Chen E, Murai J, Siiteri PK & Chen S 1993 Aromatase gene is amplified in MCF-7 human breast cancer cells. Journal of Steroid Biochemistry and Molecular Biology 46 147-153.
34. Zhou D, Clarke P, Wang J & Chen S 1996a Identification of a promoter that controls aromatase expression in human breast cancer and adipose stromal cells. Journal of Biological Chemistry 271 15194-15202.
35. Zhou C, Zhou D, Esteban J, Murai J, Siiteri PK, Wilczynski S & Chen S 1996b Aromatase gene expression and its exon I usage in human breast tumors. Detection of aromatase messenger RNA by reverse transcription-polymerase chain reaction (RT-PCR). Journal of Steroid Biochemistry and Molecular Biology 59 163-171.