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Volumn 3, Issue 1, 1996, Pages 41-56

17β-Hydroxysteroid dehydrogenase: Inhibitors and inhibitor design

Author keywords

[No Author keywords available]

Indexed keywords

ANTIESTROGEN; CLOMIFENE; DIETHYLSTILBESTROL; ENZYME INHIBITOR; ESTROGEN; HEXESTROL; PYRAZOLE DERIVATIVE; TESTOSTERONE 17BETA DEHYDROGENASE;

EID: 0029998812     PISSN: 13510088     EISSN: None     Source Type: Journal    
DOI: 10.1677/erc.0.0030041     Document Type: Review
Times cited : (80)

References (64)
  • 1
    • 0023933308 scopus 로고
    • Steroidal regulation of oestradiol-17β dehydrogenase activity of the human breast cancer cell line MCF-7
    • Adams EF, Coldham NG & James VH 1988 Steroidal regulation of oestradiol-17β dehydrogenase activity of the human breast cancer cell line MCF-7. Journal of Endocrinology 118 149-154.
    • (1988) Journal of Endocrinology , vol.118 , pp. 149-154
    • Adams, E.F.1    Coldham, N.G.2    James, V.H.3
  • 4
    • 0015935806 scopus 로고
    • Affinity labeling of steroid binding sites. Study of the active site of 20βhydroxysteroid dehydrogenase with 6β- and 11αbromoacetoxy-progesterone
    • Arias F, Sweet F & Warren JC 1973 Affinity labeling of steroid binding sites. Study of the active site of 20βhydroxysteroid dehydrogenase with 6β- and 11αbromoacetoxy-progesterone. Journal of Biological Chemistry 248 5641-5647.
    • (1973) Journal of Biological Chemistry , vol.248 , pp. 5641-5647
    • Arias, F.1    Sweet, F.2    Warren, J.C.3
  • 5
    • 0022845066 scopus 로고
    • Mechanism-based inactivation of 17β,20α-hydroxysteroid dehydrogenase by an acetylenic secoestradiol
    • Auchus RJ & Covey DF 1986 Mechanism-based inactivation of 17β,20α-hydroxysteroid dehydrogenase by an acetylenic secoestradiol. Biochemistry 25 7295-7300.
    • (1986) Biochemistry , vol.25 , pp. 7295-7300
    • Auchus, R.J.1    Covey, D.F.2
  • 7
    • 0023732025 scopus 로고
    • Solid-state NMR observation of cysteine and lysine Michael adducts of inactivated estradiol dehydrogenase
    • Auchus RJ, Covey DF, Bork V & Schaefer J 1988 Solid-state NMR observation of cysteine and lysine Michael adducts of inactivated estradiol dehydrogenase. Journal of Biological Chemistry 263 11640-11645.
    • (1988) Journal of Biological Chemistry , vol.263 , pp. 11640-11645
    • Auchus, R.J.1    Covey, D.F.2    Bork, V.3    Schaefer, J.4
  • 8
    • 0015217629 scopus 로고
    • Reaction mechanism of 17β-estradiol dehydrogenase determined by equilibrium rate exchange
    • Betz G 1971 Reaction mechanism of 17β-estradiol dehydrogenase determined by equilibrium rate exchange. Journal of Biological Chemistry 246 2063-2068.
    • (1971) Journal of Biological Chemistry , vol.246 , pp. 2063-2068
    • Betz, G.1
  • 10
    • 0021705989 scopus 로고
    • Inhibition of 17β-hydroxysteroid dehydrogenase (17βHSD) activities of human placenta by steroids and nonsteroidal hormone agonists and antagonists
    • Blomquist CH, Lindemann NJ & Hakanson EY 1984 Inhibition of 17β-hydroxysteroid dehydrogenase (17βHSD) activities of human placenta by steroids and nonsteroidal hormone agonists and antagonists. Steroids 43 571-586.
    • (1984) Steroids , vol.43 , pp. 571-586
    • Blomquist, C.H.1    Lindemann, N.J.2    Hakanson, E.Y.3
  • 11
    • 0021884506 scopus 로고
    • 17β-Hydroxysteroid and 20α-hydroxysteroid dehydrogenase activities of human placental microsomes: Kinetic evidence for two enzymes differing in substrate specificity
    • Blomquist CH, Lindemann NJ & Hakanson EY 1985 17β-Hydroxysteroid and 20α-hydroxysteroid dehydrogenase activities of human placental microsomes: kinetic evidence for two enzymes differing in substrate specificity. Archives of Biochemistry and Biophysics 239 206-215.
    • (1985) Archives of Biochemistry and Biophysics , vol.239 , pp. 206-215
    • Blomquist, C.H.1    Lindemann, N.J.2    Hakanson, E.Y.3
  • 12
    • 0016784261 scopus 로고
    • The mechanism of the bond forming events in pyridine nucleotide linked oxidoreductases. Studies with epoxide inhibitors of lactic dehydrogenase and β-hydroxy-butyrate dehydrogenase
    • Bloxham DP, Giles IG, Wilton DC & Akhtar M 1975 The mechanism of the bond forming events in pyridine nucleotide linked oxidoreductases. Studies with epoxide inhibitors of lactic dehydrogenase and β-hydroxy-butyrate dehydrogenase. Biochemistry 14 2235-2241.
    • (1975) Biochemistry , vol.14 , pp. 2235-2241
    • Bloxham, D.P.1    Giles, I.G.2    Wilton, D.C.3    Akhtar, M.4
  • 13
    • 0027309435 scopus 로고
    • Site-specific mutagenesis of Drosophila alcohol dehydrogenase: Evidence for involvement of tyrosine-152 and lysine-156 in catalysis
    • Chen Z, Jiang JC, Lin ZG, Lee WR, Baker ME & Chang SH 1993 Site-specific mutagenesis of Drosophila alcohol dehydrogenase: evidence for involvement of tyrosine-152 and lysine-156 in catalysis. Biochemistry 32 3342-3346.
    • (1993) Biochemistry , vol.32 , pp. 3342-3346
    • Chen, Z.1    Jiang, J.C.2    Lin, Z.G.3    Lee, W.R.4    Baker, M.E.5    Chang, S.H.6
  • 14
    • 0016593954 scopus 로고
    • Synthesis of 16α-bromoacetoxyestradiol 3-methyl ether and study of the steroid binding site of human placental estradiol 17βdehydrogenase
    • Chin CC & Warren JC 1975 Synthesis of 16α- bromoacetoxyestradiol 3-methyl ether and study of the steroid binding site of human placental estradiol 17βdehydrogenase. Journal of Biological Chemistry 250 7682-7686.
    • (1975) Journal of Biological Chemistry , vol.250 , pp. 7682-7686
    • Chin, C.C.1    Warren, J.C.2
  • 15
    • 0027473495 scopus 로고
    • Androgen receptor-mediated stimulation of 17βhydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxyprogesterone acetate in ZR-75-1 human breast cancer cells
    • Couture P, Theriault C, Simard J & Labrie F 1993 Androgen receptor-mediated stimulation of 17βhydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxyprogesterone acetate in ZR-75-1 human breast cancer cells. Endocrinology 132 179-185.
    • (1993) Endocrinology , vol.132 , pp. 179-185
    • Couture, P.1    Theriault, C.2    Simard, J.3    Labrie, F.4
  • 16
    • 0018728769 scopus 로고
    • Synthesis of 17β-[(1S)-1-hydroxy-2-propynyl]- and 17β-[(1R)-1-hydroxy-2propynyl]androst-4-en-3-one. Potential suicide substrates of 20α- and 20β-hydroxysteroid dehydrogenases
    • Covey DF 1979 Synthesis of 17β-[(1S)-1-hydroxy-2-propynyl]- and 17β-[(1R)-1-hydroxy-2propynyl]androst-4-en-3-one. Potential suicide substrates of 20α- and 20β-hydroxysteroid dehydrogenases. Steroids 34 199-206.
    • (1979) Steroids , vol.34 , pp. 199-206
    • Covey, D.F.1
  • 18
    • 0027285384 scopus 로고
    • Ten years experience with masculinizing genitoplasty in male pseudohermaphroditism due to 17β-hydroxysteroid dehydrogenase deficiency
    • Farkas A & Rosler A 1993 Ten years experience with masculinizing genitoplasty in male pseudohermaphroditism due to 17β-hydroxysteroid dehydrogenase deficiency. European Journal of Pediatrics 152 (Suppl) S88-S90.
    • (1993) European Journal of Pediatrics , vol.152 , Issue.SUPPL.
    • Farkas, A.1    Rosler, A.2
  • 21
    • 0028773893 scopus 로고
    • The refined three-dimensional structure of 3α,20β-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases
    • Ghosh D, Wawrzak Z, Weeks CM, Duax WL & Erman M 1994 The refined three-dimensional structure of 3α,20β-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases. Structure 2 629-640.
    • (1994) Structure , vol.2 , pp. 629-640
    • Ghosh, D.1    Wawrzak, Z.2    Weeks, C.M.3    Duax, W.L.4    Erman, M.5
  • 24
    • 0016685032 scopus 로고
    • Relationship between steroids and pyridine nucleotides in the oxido-reduction catalyzed by the 17&-hydroxysteroid dehydrogenase purified from the porcine testicular microsomal fraction
    • Inano H & Tamaoki B 1975 Relationship between steroids and pyridine nucleotides in the oxido-reduction catalyzed by the 17&-hydroxysteroid dehydrogenase purified from the porcine testicular microsomal fraction. European Journal of Biochemistry 53 319-326.
    • (1975) European Journal of Biochemistry , vol.53 , pp. 319-326
    • Inano, H.1    Tamaoki, B.2
  • 25
    • 0023212828 scopus 로고
    • Testicular 17β-hydroxysteroid dehydrogenase: Molecular properties and reaction mechanism
    • Inano H & Tamaoki B 1986 Testicular 17β-hydroxysteroid dehydrogenase: molecular properties and reaction mechanism. Steroids 48 1-26.
    • (1986) Steroids , vol.48 , pp. 1-26
    • Inano, H.1    Tamaoki, B.2
  • 26
    • 2342459418 scopus 로고
    • Stereospecificity of hydrogen transfer by pyridine nucleotide-linked hydroxysteroid dehydrogenases
    • Jarabak J & Talalay P 1960 Stereospecificity of hydrogen transfer by pyridine nucleotide-linked hydroxysteroid dehydrogenases. Journal of Biological Chemistry 235 2147-2154.
    • (1960) Journal of Biological Chemistry , vol.235 , pp. 2147-2154
    • Jarabak, J.1    Talalay, P.2
  • 27
    • 0014512087 scopus 로고
    • Soluble 17β-hydroxysteroid dehydrogenase from human placenta. The binding of pyridine nucleotides and steroids
    • Jarabak J & Sack GH Jr 1969 Soluble 17β-hydroxysteroid dehydrogenase from human placenta. The binding of pyridine nucleotides and steroids. Biochemistry 8 2203-2212.
    • (1969) Biochemistry , vol.8 , pp. 2203-2212
    • Jarabak, J.1    Sack Jr., G.H.2
  • 28
    • 33846403055 scopus 로고
    • Purification of a 17β-hydroxysteroid dehydrogenase of human placenta and studies on its transhydrogenase function
    • Jarabak J, Adams JA, Williams-Ashman HG & Talalay P 1962 Purification of a 17β-hydroxysteroid dehydrogenase of human placenta and studies on its transhydrogenase function. Journal of Biological Chemistry 237 345-357.
    • (1962) Journal of Biological Chemistry , vol.237 , pp. 345-357
    • Jarabak, J.1    Adams, J.A.2    Williams-Ashman, H.G.3    Talalay, P.4
  • 31
    • 0027959548 scopus 로고
    • The short-chain alcohol dehydrogenase superfamily : Variations on a common theme
    • Krozowski Z 1994 The short-chain alcohol dehydrogenase superfamily : variations on a common theme. Journal of Steroid Biochemistry and Molecular Biology 51 125-130.
    • (1994) Journal of Steroid Biochemistry and Molecular Biology , vol.51 , pp. 125-130
    • Krozowski, Z.1
  • 32
    • 0025034471 scopus 로고
    • Trifluoromethylacetylenic alcohols as affinity labels. Inactivation of estradiol dehydrogenase by a trifluoromethylacetylenic secostradiol
    • Lawate SS & Covey DF 1990 Trifluoromethylacetylenic alcohols as affinity labels. Inactivation of estradiol dehydrogenase by a trifluoromethylacetylenic secostradiol. Journal of Medicinal Chemistry 33 2319-2321.
    • (1990) Journal of Medicinal Chemistry , vol.33 , pp. 2319-2321
    • Lawate, S.S.1    Covey, D.F.2
  • 33
    • 0023201983 scopus 로고
    • Inhibition of 3(17)β-hydroxysteroid dehydrogenase from Pseudomonas testosteroni by steroidal A ring fused pyrazoles
    • Levy MA, Holt DA, Brandt M & Metcalf BW 1987 Inhibition of 3(17)β-hydroxysteroid dehydrogenase from Pseudomonas testosteroni by steroidal A ring fused pyrazoles. Biochemistry 26 2270-2279.
    • (1987) Biochemistry , vol.26 , pp. 2270-2279
    • Levy, M.A.1    Holt, D.A.2    Brandt, M.3    Metcalf, B.W.4
  • 36
    • 0024361957 scopus 로고
    • Characterization of cDNAs for human estradiol 17β-dehydrogenase and assignment of the gene to chromosome 17: Evidence of two mRNA species with distinct 5′-termini in human placenta
    • Luu-The V, Labrie C, Zhao HF, Couet J, Lachance Y, Simard J, Leblanc G, Cote J, Berube D, Gagne R & Labrie F 1989 Characterization of cDNAs for human estradiol 17β-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5′-termini in human placenta. Molecular Endocrinology 3 1301-1309.
    • (1989) Molecular Endocrinology , vol.3 , pp. 1301-1309
    • Luu-The, V.1    Labrie, C.2    Zhao, H.F.3    Couet, J.4    Lachance, Y.5    Simard, J.6    Leblanc, G.7    Cote, J.8    Berube, D.9    Gagne, R.10    Labrie, F.11
  • 39
    • 0022534769 scopus 로고
    • Human placental estradiol 17β-dehydrogenase: Sequence of a histidine-bearing peptide in the catalytic region
    • Murdock GL, Chin CC & Warren JC 1986 Human placental estradiol 17β-dehydrogenase: sequence of a histidine-bearing peptide in the catalytic region. Biochemistry 25 641-646.
    • (1986) Biochemistry , vol.25 , pp. 641-646
    • Murdock, G.L.1    Chin, C.C.2    Warren, J.C.3
  • 41
    • 0026445622 scopus 로고
    • Tyr-179 and Lys-183 are essential for the enzymatic activity of 11βhydroxysteroid dehydrogenase
    • Obeid J & White PC 1992 Tyr-179 and Lys-183 are essential for the enzymatic activity of 11βhydroxysteroid dehydrogenase. Biochemical and Biophysical Research Communications 188 222-227.
    • (1992) Biochemical and Biophysical Research Communications , vol.188 , pp. 222-227
    • Obeid, J.1    White, P.C.2
  • 42
    • 0028059981 scopus 로고
    • N-butyl,N-methyl,11-[3′, 17′β-(dihydroxy)-1′,3′,5′(10′)-estratrien- 16′-alpha-yl]-9(R/S)-bromo undecanamide: Synthesis and 17β-HSD inhibiting, estrogenic and antiestrogenic activities
    • Pelletier JD, Labrie F & Poirier D 1994 N-butyl,N-methyl,11-[3′, 17′β-(dihydroxy)-1′,3′,5′(10′)-estratrien- 16′-alpha-yl]-9(R/S)-bromo undecanamide: synthesis and 17β-HSD inhibiting, estrogenic and antiestrogenic activities. Steroids 59 536-547.
    • (1994) Steroids , vol.59 , pp. 536-547
    • Pelletier, J.D.1    Labrie, F.2    Poirier, D.3
  • 43
    • 0023691704 scopus 로고
    • Complete amino acid sequence of human placental 17βhydroxysteroid dehydrogenase deduced from cDNA
    • Peltoketo H, Isomaa V, Maentausta O & Vihko R 1988 Complete amino acid sequence of human placental 17βhydroxysteroid dehydrogenase deduced from cDNA. FEBS Letters 239 73-77.
    • (1988) FEBS Letters , vol.239 , pp. 73-77
    • Peltoketo, H.1    Isomaa, V.2    Maentausta, O.3    Vihko, R.4
  • 44
    • 0025741147 scopus 로고
    • Mechanism based inhibition of hydroxysteroid dehydrogenases
    • Penning TM & Ricigliano JW 1991 Mechanism based inhibition of hydroxysteroid dehydrogenases. Journal of Enzyme Inhibition 5 165-198.
    • (1991) Journal of Enzyme Inhibition , vol.5 , pp. 165-198
    • Penning, T.M.1    Ricigliano, J.W.2
  • 45
    • 0026040499 scopus 로고
    • Clues to the development of mechanism-based inactivators of 3α-hydroxysteroid dehydrogenase: Comparison of steroidal and nonsteroidal Michael acceptors and epoxides
    • Penning TM, Thornton R & Ricigliano JW 1991 Clues to the development of mechanism-based inactivators of 3α-hydroxysteroid dehydrogenase: comparison of steroidal and nonsteroidal Michael acceptors and epoxides. Steroids 56 420-427.
    • (1991) Steroids , vol.56 , pp. 420-427
    • Penning, T.M.1    Thornton, R.2    Ricigliano, J.W.3
  • 46
    • 0027959919 scopus 로고
    • Site-directed mutagenesis of the putative active site of human 17β-hydroxysteroid dehydrogenase type 1
    • Puranen TJ, Poutanen MH, Peltoketo HE, Vihko PT & Vihko RK 1994 Site-directed mutagenesis of the putative active site of human 17β-hydroxysteroid dehydrogenase type 1. Biochemical Journal 304 289-293.
    • (1994) Biochemical Journal , vol.304 , pp. 289-293
    • Puranen, T.J.1    Poutanen, M.H.2    Peltoketo, H.E.3    Vihko, P.T.4    Vihko, R.K.5
  • 47
    • 0016184254 scopus 로고
    • Chemistry and enzymology of kcat inhibitors
    • Rando RR 1974a Chemistry and enzymology of kcat inhibitors. Science 185 320-324.
    • (1974) Science , vol.185 , pp. 320-324
    • Rando, R.R.1
  • 48
    • 0016254364 scopus 로고
    • Allyl alcohol-induced irreversible inhibition of yeast alcohol dehydrogenase
    • Rando RR 1974b Allyl alcohol-induced irreversible inhibition of yeast alcohol dehydrogenase. Biochemical Pharmacology 23 2328-2331.
    • (1974) Biochemical Pharmacology , vol.23 , pp. 2328-2331
    • Rando, R.R.1
  • 49
    • 0024451317 scopus 로고
    • Synthesis and evaluation of non-steroidal mechanism-based inactivators of 3α-hydroxysteroid dehydrogenase
    • Ricigliano JW & Penning TM 1989 Synthesis and evaluation of non-steroidal mechanism-based inactivators of 3α-hydroxysteroid dehydrogenase. Biochemical Journal 262 139-149.
    • (1989) Biochemical Journal , vol.262 , pp. 139-149
    • Ricigliano, J.W.1    Penning, T.M.2
  • 50
    • 0025326564 scopus 로고
    • Evidence that enzyme-generated aromatic Michael acceptors covalently modify the nucleotide-binding site of 3αhydroxysteroid dehydrogenase
    • Ricigliano JW & Penning TM 1990 Evidence that enzyme-generated aromatic Michael acceptors covalently modify the nucleotide-binding site of 3αhydroxysteroid dehydrogenase. Biochemical Journal 269 749-755.
    • (1990) Biochemical Journal , vol.269 , pp. 749-755
    • Ricigliano, J.W.1    Penning, T.M.2
  • 53
    • 0016685688 scopus 로고
    • Affinity labeling of steroid binding sites. Study of the active site of 20β-hydroxysteroid dehydrogenase with 2α-bromoacetoxyprogesterone and 11α-bromoacetoxyprogesterone
    • Strickler RC, Sweet F & Warren JC 1975 Affinity labeling of steroid binding sites. Study of the active site of 20β-hydroxysteroid dehydrogenase with 2α-bromoacetoxyprogesterone and 11α-bromoacetoxyprogesterone. Journal of Biological Chemistry 250 7656-7662.
    • (1975) Journal of Biological Chemistry , vol.250 , pp. 7656-7662
    • Strickler, R.C.1    Sweet, F.2    Warren, J.C.3
  • 54
    • 0015501063 scopus 로고
    • Affinity labeling of steroid binding sites. Synthesis of 16-bromoacetoxyprogesterone and its use for affinity labeling 20-hydroxysteroid dehydrogenase
    • Sweet F, Arias F & Warren JC 1972 Affinity labeling of steroid binding sites. Synthesis of 16-bromoacetoxyprogesterone and its use for affinity labeling 20-hydroxysteroid dehydrogenase. Journal of Biological Chemistry 247 3424-3433.
    • (1972) Journal of Biological Chemistry , vol.247 , pp. 3424-3433
    • Sweet, F.1    Arias, F.2    Warren, J.C.3
  • 55
    • 78651121376 scopus 로고
    • Liver alcohol dehydrogenase-DPN-pyrazole complex: A model of a ternary intermediate in the enzyme reaction
    • Theorell H & Yonetani T 1963 Liver alcohol dehydrogenase-DPN-pyrazole complex: a model of a ternary intermediate in the enzyme reaction. Biochemische Zeitschrift 338 537-553.
    • (1963) Biochemische Zeitschrift , vol.338 , pp. 537-553
    • Theorell, H.1    Yonetani, T.2
  • 56
    • 0014449302 scopus 로고
    • On the effects of some heterocyclic compounds on the enzymic activity of liver alcohol dehydrogenase
    • Theorell H, Yonetani T & Sjoberg B 1969 On the effects of some heterocyclic compounds on the enzymic activity of liver alcohol dehydrogenase. Acta Chemica Scandinavica 23 255-260.
    • (1969) Acta Chemica Scandinavica , vol.23 , pp. 255-260
    • Theorell, H.1    Yonetani, T.2    Sjoberg, B.3
  • 57
    • 0020514222 scopus 로고
    • Inactivation of human placental 17β,20αhydroxysteroid dehydrogenase by 16-methylene estrone, an affinity alkylator enzymatically generated from 16-methylene estradiol-17β
    • Thomas JL, LaRochelle MC, Covey DF & Strickler RC 1983 Inactivation of human placental 17β,20αhydroxysteroid dehydrogenase by 16-methylene estrone, an affinity alkylator enzymatically generated from 16-methylene estradiol-17β. Journal of Biological Chemistry 258 11500-11504.
    • (1983) Journal of Biological Chemistry , vol.258 , pp. 11500-11504
    • Thomas, J.L.1    LaRochelle, M.C.2    Covey, D.F.3    Strickler, R.C.4
  • 58
    • 0020471327 scopus 로고
    • Inactivation of human placental 17β-estradiol dehydrogenase and 20αhydroxysteroid dehydrogenase with active site-directed 17β-propynyl-substituted progestin analogs
    • Tobias B, Covey DF & Strickler RC 1982 Inactivation of human placental 17β-estradiol dehydrogenase and 20αhydroxysteroid dehydrogenase with active site-directed 17β-propynyl-substituted progestin analogs. Journal of Biological Chemistry 257 2783-2786.
    • (1982) Journal of Biological Chemistry , vol.257 , pp. 2783-2786
    • Tobias, B.1    Covey, D.F.2    Strickler, R.C.3
  • 59
    • 0029011261 scopus 로고
    • Synthesis of 16(bromoalkyl)-estradiols having inhibitory effects on human placental estradiol 17β-hydroxysteroid dehydrogenases (17β-HSD Type 1)
    • Tremblay MR, Auger S & Poirer D 1995 Synthesis of 16(bromoalkyl)-estradiols having inhibitory effects on human placental estradiol 17β-hydroxysteroid dehydrogenases (17β-HSD Type 1). Bioorganic and Medicinal Chemistry 3 505-523.
    • (1995) Bioorganic and Medicinal Chemistry , vol.3 , pp. 505-523
    • Tremblay, M.R.1    Auger, S.2    Poirer, D.3
  • 60
    • 0022642042 scopus 로고
    • Aromatase, 17β-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women
    • Vermeulen A, Deslypere JP, Paridaens R, Leclerq G, Roy F & Heusen JC 1986 Aromatase, 17β-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women. European Journal of Cancer and Clinical Oncology 22 515-525.
    • (1986) European Journal of Cancer and Clinical Oncology , vol.22 , pp. 515-525
    • Vermeulen, A.1    Deslypere, J.P.2    Paridaens, R.3    Leclerq, G.4    Roy, F.5    Heusen, J.C.6
  • 61
    • 0021192474 scopus 로고
    • Suicide substrates, mechanism-based enzyme inactivators: Recent developments
    • Walsh CT 1984 Suicide substrates, mechanism-based enzyme inactivators: recent developments. Annual Review of Biochemistry 53 493-535.
    • (1984) Annual Review of Biochemistry , vol.53 , pp. 493-535
    • Walsh, C.T.1
  • 62
    • 0023146457 scopus 로고
    • Incomplete masculinization due to a deficiency of 17βhydroxysteroid dehydrogenase: Comparison of prepubertal and peripubertal siblings
    • Wilson SC, Hodgins, MB & Scott JS 1987 Incomplete masculinization due to a deficiency of 17βhydroxysteroid dehydrogenase: comparison of prepubertal and peripubertal siblings. Clinical Endocrinology 26 459-469.
    • (1987) Clinical Endocrinology , vol.26 , pp. 459-469
    • Wilson, S.C.1    Hodgins, M.B.2    Scott, J.S.3
  • 63
    • 0023885941 scopus 로고
    • Steroid metabolism in testes of patients with incomplete masculinization due to androgen insensitivity or 17β-hydroxysteroid dehydrogenase deficiency and normally differentiated males
    • Wilson SC, Oakey RE & Scott JS 1988 Steroid metabolism in testes of patients with incomplete masculinization due to androgen insensitivity or 17β-hydroxysteroid dehydrogenase deficiency and normally differentiated males. Journal of Steroid Biochemistry 29 649-655.
    • (1988) Journal of Steroid Biochemistry , vol.29 , pp. 649-655
    • Wilson, S.C.1    Oakey, R.E.2    Scott, J.S.3
  • 64
    • 0027225486 scopus 로고
    • Expression cloning and characterization of human 17β-hydroxysteroid dehydrogenase type 2: A microsomal enzyme possessing 20α-hydroxysteroid dehydrogenase activity
    • Wu L, Einstein M, Geissler WM, Chan HK, Elliston KO & Andersson S 1993 Expression cloning and characterization of human 17β-hydroxysteroid dehydrogenase type 2: a microsomal enzyme possessing 20α-hydroxysteroid dehydrogenase activity. Journal of Biological Chemistry 268 12964-12969.
    • (1993) Journal of Biological Chemistry , vol.268 , pp. 12964-12969
    • Wu, L.1    Einstein, M.2    Geissler, W.M.3    Chan, H.K.4    Elliston, K.O.5    Andersson, S.6


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