20-Amino and 20,21-aziridinyl pregnene steroids: Development of potent inhibitors of 17α-hydroxilase/C17,20-lyase (P450 17)

Bioorganic and Medicinal Chemistry

Volumn 4, Issue 9, 1996, Pages 1447-1453

  Njar, Vincent C O ^a,b   Hector, Markus ^a   Hartmann, Rolf W ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

17 hydroxylase C17,20 lyase (P450 17) inhibitors; 20,21 aziridinylpregnenes; 20 aminopregnenes; Androgen dependent diseases

Indexed keywords

CYTOCHROME P450; PREGNENOLONE DERIVATIVE; PROGESTERONE; PROGESTERONE DERIVATIVE; STEROID 17,20 LYASE;

ANDROGEN SYNTHESIS; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; IN VITRO STUDY; MALE; NONHUMAN; RAT; STEROIDOGENESIS; STRUCTURE ACTIVITY RELATION; TESTIS; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 0029763950     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/0968-0896(96)00138-1     Document Type: Article

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