3- and 4-pyridylalkyl adamantanecarboxylates: Inhibitors of human cytochrome P450(17α) (17α-hydroxylase/C17,20-lyase). Potential nonsteroidal agents for the treatment of prostatic cancer

Journal of Medicinal Chemistry

Volumn 39, Issue 17, 1996, Pages 3319-3323

  Chan, Ferdinand C Y ^a,b   Potter, Gerard A ^a,c   Barrie, S Elaine ^a   Haynes, Benjamin P ^a   Rowlands, Martin G ^a   Houghton, John ^a   Jarman, Michael ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b Chemical Company of Malaysia Berhad   (Malaysia)

^c Chiroscience Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADAMANTANE DERIVATIVE; ANTINEOPLASTIC AGENT; CYTOCHROME P450 INHIBITOR;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; ESTERIFICATION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PROSTATE CANCER; RAT; STRUCTURE ACTIVITY RELATION;

ADAMANTANE; ANIMALS; ANTINEOPLASTIC AGENTS; ENZYME INHIBITORS; ESTERASES; HUMANS; KINETICS; MALE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PROSTATIC NEOPLASMS; RATS; STEROID 17-ALPHA-HYDROXYLASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029763048     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950749y     Document Type: Article

References (14)

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