Inhibition of human steroid 5α reductases type I and II by 6-aza-steroids: Structural determinants of one-step vs two-step mechanism

Biochemistry

Volumn 35, Issue 11, 1996, Pages 3457-3464

  Moss, Marcia L ^a   Kuzmič, Petr ^b   Stuart, J Darren ^b   Tian, Gaochao ^b   Peranteau, Anne G ^b   Frye, Stephen V ^b   Kadwell, Sue H ^b   Kost, Thomas A ^b   Overton, Laurie K ^b   Patel, Indravadan R ^b  

^a GLAXOSMITHKLINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

17BETA (N,N DIETHYLCARBAMOYL) 6 AZAANDROST 4 EN 3 ONE; 6 AZASTEROID DERIVATIVE; FINASTERIDE; STEROID 5ALPHA REDUCTASE; STEROID 5ALPHA REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG MECHANISM; ENZYME INHIBITOR INTERACTION; ENZYME MECHANISM; HUMAN; INHIBITION KINETICS; PRIORITY JOURNAL; REACTION ANALYSIS;

AZASTEROIDS; ENZYME INHIBITORS; FINASTERIDE; HUMANS; ISOENZYMES; KINETICS; STRUCTURE-ACTIVITY RELATIONSHIP; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 0029880422     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi952472+     Document Type: Article

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