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Volumn 58, Issue 4, 1996, Pages 377-384

MK386: A potent, selective inhibitor of the human type 1 5α-reductase

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; AROMATASE; ISOENZYME; RECOMBINANT PROTEIN; STEROID 5ALPHA REDUCTASE INHIBITOR; STEROID 5BETA REDUCTASE; TESTOSTERONE 17BETA DEHYDROGENASE;

EID: 0030200204     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-0760(96)00050-7     Document Type: Article
Times cited : (33)

References (27)
  • 1
    • 0024397969 scopus 로고
    • Inhibitors of 5α-reductase in benign prostatic hyperplasia, male pattern baldness and acne
    • 1. Metcalf B. W., Levy M. A. and Holt D. A.: Inhibitors of 5α-reductase in benign prostatic hyperplasia, male pattern baldness and acne. Trends Pharmac. Sci. 10 (1989) 491-495.
    • (1989) Trends Pharmac. Sci. , vol.10 , pp. 491-495
    • Metcalf, B.W.1    Levy, M.A.2    Holt, D.A.3
  • 2
    • 0029055505 scopus 로고
    • The enzyme and inhibitors of 4-ene-3-oxosteroid 5α-reductase
    • 2. Li X., Chem C., Singh S. M. and Labrie F.: The enzyme and inhibitors of 4-ene-3-oxosteroid 5α-reductase. Steroids 60 (1995) 430-441.
    • (1995) Steroids , vol.60 , pp. 430-441
    • Li, X.1    Chem, C.2    Singh, S.M.3    Labrie, F.4
  • 3
    • 0001315562 scopus 로고
    • Inhibitors of steroid 5α-reductase
    • (Edited by M. Samdler and H. J. Smith). Oxford University Press, Oxford
    • 3. Brooks J. R., Harris, G. S. and Rasmusson G. R.: Inhibitors of steroid 5α-reductase. In Design of Enzyme Inhibitors as Drugs (Edited by M. Samdler and H. J. Smith). Oxford University Press, Oxford (1994) pp. 495-518.
    • (1994) Design of Enzyme Inhibitors As Drugs , pp. 495-518
    • Brooks, J.R.1    Harris, G.S.2    Rasmusson, G.R.3
  • 11
    • 0001040796 scopus 로고
    • Effect of multiple doses of epristeride (E) a steroid 5α-reductase inhibitor on serum dihydrotestosterone in older male subjects
    • 11. Audet P., Nurcombe H., Lamb Y., Jorasky D., Lloyd-Davis K. and Morris X. X.: Effect of multiple doses of epristeride (E) a steroid 5α-reductase inhibitor on serum dihydrotestosterone in older male subjects. Clin. Pharmacol. Ther. 53 (1993) 231-233.
    • (1993) Clin. Pharmacol. Ther. , vol.53 , pp. 231-233
    • Audet, P.1    Nurcombe, H.2    Lamb, Y.3    Jorasky, D.4    Lloyd-Davis, K.5    Morris, X.X.6
  • 12
    • 0026503988 scopus 로고
    • Finasteride, an inhibitor of 5α-reductase suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia
    • 12. McConnell J. D., Wilson J. D., George F. W., Geller J., Pappas F. and Stoner E.: Finasteride, an inhibitor of 5α-reductase suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia. J. Clin. Endocr. Metab. 74 (1992) 505-508.
    • (1992) J. Clin. Endocr. Metab. , vol.74 , pp. 505-508
    • McConnell, J.D.1    Wilson, J.D.2    George, F.W.3    Geller, J.4    Pappas, F.5    Stoner, E.6
  • 13
    • 0029101544 scopus 로고
    • Activity of the type 1 5α-reductase exhibits regional differences in isolated sebaceous glands and whole skin
    • 13. Thiboutot D., Harris G., Iles V., Cimis G., Gilliland K. and Hagari S.: Activity of the type 1 5α-reductase exhibits regional differences in isolated sebaceous glands and whole skin. J. Invest. Dermatol. 105 (1995) 209-214.
    • (1995) J. Invest. Dermatol. , vol.105 , pp. 209-214
    • Thiboutot, D.1    Harris, G.2    Iles, V.3    Cimis, G.4    Gilliland, K.5    Hagari, S.6
  • 15
    • 0001794247 scopus 로고
    • Characterization of human steroid 5α-reductase type 1 and 2 expressed in the baculovirus system
    • (Edited by M. Motta and M. Serio). Elsevier Science M.V., Amsterdam
    • 15. Chan H. K., Geissler W. M. and Andersson S.: Characterization of human steroid 5α-reductase type 1 and 2 expressed in the baculovirus system. In Sex Hormones and Antihormones in Endocrine Dependent Pathology: Basic and Clinical Aspects (Edited by M. Motta and M. Serio). Elsevier Science M.V., Amsterdam (1994), pp. 67-76.
    • (1994) Sex Hormones and Antihormones in Endocrine Dependent Pathology: Basic and Clinical Aspects , pp. 67-76
    • Chan, H.K.1    Geissler, W.M.2    Andersson, S.3
  • 16
    • 0023728105 scopus 로고
    • The behavior and significance of slow-binding enzyme inhibitors
    • 16. Morrison J. F. and Walsh C. T.: The behavior and significance of slow-binding enzyme inhibitors. Adv. Enzymol. Relat. Areas Molec. Biol. 61 (1988) 201-301.
    • (1988) Adv. Enzymol. Relat. Areas Molec. Biol. , vol.61 , pp. 201-301
    • Morrison, J.F.1    Walsh, C.T.2
  • 17
    • 1842318283 scopus 로고
    • Characterization and expression of a cdna encoding the human androgen receptor
    • 17. Tilley W. D., Marcelli M., Wilson J. D. and McPhaul M. J.: Characterization and expression of a cDNA encoding the human androgen receptor. Proc. Natn. Acad. Sci. U.S.A. 86 (1989) 327-331.
    • (1989) Proc. Natn. Acad. Sci. U.S.A. , vol.86 , pp. 327-331
    • Tilley, W.D.1    Marcelli, M.2    Wilson, J.D.3    McPhaul, M.J.4
  • 19
    • 0027256289 scopus 로고
    • Finasteride: A slow-binding 5α-reductase inhibitor
    • 19. Faller B., Farley D. and Nick H.: Finasteride: A slow-binding 5α-reductase inhibitor. Biochemistry 32 (1993) 5705-5710.
    • (1993) Biochemistry , vol.32 , pp. 5705-5710
    • Faller, B.1    Farley, D.2    Nick, H.3
  • 20
    • 4243507208 scopus 로고
    • Mechanism of inhibition of human prostatic 5α-reductase by 4-azasteroids
    • 20. Baginsky W. F., Harris G. and Bull H.: Mechanism of inhibition of human prostatic 5α-reductase by 4-azasteroids. FASEB J. 8 (1994) A638.
    • (1994) FASEB J. , vol.8
    • Baginsky, W.F.1    Harris, G.2    Bull, H.3
  • 21
    • 0019817263 scopus 로고
    • Inhibition of 5α-reductase, receptor binding and nuclear uptake of androgens in the prostate by a 4-methyl-4-aza-steroid
    • 21. Liang T. and Heiss C. E.: Inhibition of 5α-reductase, receptor binding and nuclear uptake of androgens in the prostate by a 4-methyl-4-aza-steroid. J. Biol. Chem. 256 (1981) 7998-8005.
    • (1981) J. Biol. Chem. , vol.256 , pp. 7998-8005
    • Liang, T.1    Heiss, C.E.2
  • 22
    • 0024548207 scopus 로고
    • 5-steroid isomerase from bovine adrenals: Mechanism of inhibition by 3-oxo-4-azasteroids and kinetic mechanism of the dehydrogenase
    • 5-steroid isomerase from bovine adrenals: Mechanism of inhibition by 3-oxo-4-azasteroids and kinetic mechanism of the dehydrogenase. Biochemistry 28 (1989) 140-148.
    • (1989) Biochemistry , vol.28 , pp. 140-148
    • Brandt, M.1    Levy, M.2
  • 23
    • 0015336002 scopus 로고
    • Studies of the human testis. 1. Biosynthetic pathways for androgen formation in human testicular tissue in vitro
    • 23. Yanaihara T. and Troen P.: Studies of the human testis. 1. Biosynthetic pathways for androgen formation in human testicular tissue in vitro. J. Clin. Endocr. Metab. 34 (1972) 783-792.
    • (1972) J. Clin. Endocr. Metab. , vol.34 , pp. 783-792
    • Yanaihara, T.1    Troen, P.2
  • 25
    • 0028173037 scopus 로고
    • 17β-hydroxysteroid dehydrogenase type 2: Chromosomal assignment and progestin regulation of gene expression in human endometrium
    • 25. Casey M. L., MacDonald P. C. and Andersson S.: 17β-hydroxysteroid dehydrogenase type 2: chromosomal assignment and progestin regulation of gene expression in human endometrium. J. Clin. Invest. 94 (1994) 2135-2141.
    • (1994) J. Clin. Invest. , vol.94 , pp. 2135-2141
    • Casey, M.L.1    Macdonald, P.C.2    Andersson, S.3
  • 27
    • 0029074108 scopus 로고
    • Tissue-specific pharmacology of testosterone and 5α-dihydrotestosterone analogues: Characterization of a novel canine liver androgen binding protein
    • 27. Summerfield A. E., Diaz Cruz P. J., Dolenga M. P., Smith H. E., Strader C. and Toney J. H.: Tissue-specific pharmacology of testosterone and 5α-dihydrotestosterone analogues: characterization of a novel canine liver androgen binding protein. Molec. Pharmacol. 47 (1995) 1080-1088.
    • (1995) Molec. Pharmacol. , vol.47 , pp. 1080-1088
    • Summerfield, A.E.1    Diaz Cruz, P.J.2    Dolenga, M.P.3    Smith, H.E.4    Strader, C.5    Toney, J.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.