Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17α- hydroxylase-C17,20-lyase (P450(17α)): Potential agents for the treatment of prostate cancer

Journal of Medicinal Chemistry

Volumn 41, Issue 6, 1998, Pages 902-912

  Njar, Vincent C O ^a,b   Kato, Katsuya ^a   Nnane, Ivo P ^a   Grigoryev, Dmitry N ^a   Long, Brian J ^a   Brodie, Angela M H ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

[No Author keywords available]

Indexed keywords

17 (1H IMIDAZOL 1 YL)ANDROSTA 4,16 DIEN 3 ONE; 3BETA HYDROXY 17 (1H 1,2,3 TRIAZOL 1 YL)ANDROSTA 5,16 DIENE; 3BETA HYDROXY 17 (1H IMIDAZOL 1 YL)ANDROSTA 5,16 DIENE; ANTIANDROGEN; CYTOCHROME B5; CYTOCHROME P450 INHIBITOR; CYTOCHROME P450 ISOENZYME; KETOCONAZOLE; STEROID 17ALPHA MONOOXYGENASE; STEROID 5ALPHA REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NONHUMAN; PROSTATE CANCER; RAT; TESTIS;

ANDROGEN ANTAGONISTS; ANDROSTADIENES; ANIMALS; ANTINEOPLASTIC AGENTS; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; KETOCONAZOLE; MALE; MICROSOMES; PROSTATIC NEOPLASMS; RATS; RATS, SPRAGUE-DAWLEY; STEROID 17-ALPHA-HYDROXYLASE; STRUCTURE-ACTIVITY RELATIONSHIP; TESTIS; TESTOSTERONE 5-ALPHA-REDUCTASE; TRIAZOLES; TUMOR CELLS, CULTURED;

EID: 0032510321     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970568r     Document Type: Article

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