Mechanism-based inhibition of human steroid 5α-reductase by finasteride: Enzyme-catalyzed formation of NADP - Dihydrofinasteride, a potent bisubstrate analog inhibitor

Journal of the American Chemical Society

Volumn 118, Issue 10, 1996, Pages 2359-2365

  Bull, Herbert G ^a   Garcia Calvo, Margarita ^a   Andersson, Stefan ^a,b   Baginsky, Walter F ^a   Chan, H Karen ^a,c   Ellsworth, Dina E ^a,d   Miller, Randall R ^a   Stearns, Ralph A ^a   Bakshi, Raman K ^a   Rasmusson, Gary H ^a   Tolman, Richard L ^a   Myers, Robert W ^a   Kozarich, John W ^a   Harris, Georgianna S ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

^d PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FINASTERIDE; ISOENZYME; STEROID 5ALPHA REDUCTASE;

ARTICLE; CONTROLLED STUDY; DISSOCIATION; DRUG METABOLISM; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; PROSTATE; SKIN;

EID: 0029937631     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja953069t     Document Type: Article

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