Application of metabolic flux analysis for the identification of metabolic bottlenecks in the biosynthesis of penicillin-G

Biotechnology and Bioengineering

Volumn 68, Issue 6, 2000, Pages 602-618

  Van Gulik, W M ^a   De Laat, W T A M ^b   Vinke, J L ^a   Heijnen, J J ^a  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b DSM RESOLVE   (Netherlands)

Author keywords

Carbon source; Chemostat; Metabolic flux manipulation; Metabolic model; Penicillin G; Penicillium chrysogenum

Indexed keywords

BIOSYNTHESIS; CARBON; CELLS; CHEMOSTATS; FERMENTATION; MATHEMATICAL MODELS; METABOLISM; STOICHIOMETRY;

METABOLIC FLUX ANALYSIS; PENICILLIN; PENICILLIUM CHRYSOGENUM;

ANTIBIOTICS;

PENICILLIN G; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANALYTIC METHOD; ARTICLE; CARBON DIOXIDE FIXATION; CELL COMPARTMENTALIZATION; CHEMOSTAT; DRUG SYNTHESIS; FERMENTATION; METABOLIC REGULATION; PENICILLIUM CHRYSOGENUM; STOICHIOMETRY;

ACETIC ACID; BIOLOGICAL TRANSPORT, ACTIVE; BIOTECHNOLOGY; CELL COMPARTMENTATION; CELL MEMBRANE; CULTURE MEDIA; CYSTEINE; CYTOSOL; ETHANOL; GLUCOSE; KINETICS; MODELS, BIOLOGICAL; NADP; PENICILLIN G; PENICILLIUM CHRYSOGENUM;

PENICILLIUM; PENICILLIUM CHRYSOGENUM;

EID: 0034691228     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(20000620)68:6<602::AID-BIT3>3.0.CO;2-2     Document Type: Article

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