Nuclear factor-κB/Rel blocks transforming growth factor β1-induced apoptosis of murine hepatocyte cell lines

Cell Growth and Differentiation

Volumn 8, Issue 10, 1997, Pages 1049-1059

  Arsura, Marcello ^a   FitzGerald, Mark J ^a   Fausto, Nelson ^b   Sonenshein, Gail E ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR FACTOR; TRANSFORMING GROWTH FACTOR BETA1; DNA BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ONCOPROTEIN; RELB PROTEIN, MOUSE; STAUROSPORINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELB; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MATURATION; DOWN REGULATION; GROWTH REGULATION; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; IMMUNOBLOTTING; LIVER; METABOLISM; PHOSPHORYLATION; TIME;

ANIMALS; APOPTOSIS; CELL LINE; DNA-BINDING PROTEINS; DOWN-REGULATION; IMMUNOBLOTTING; LIVER; MICE; NF-KAPPA B; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-REL; SIGNAL TRANSDUCTION; STAUROSPORINE; TIME FACTORS; TRANSCRIPTION FACTOR RELB; TRANSCRIPTION FACTORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 0030613532     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Sen, R., and Baltimore, D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell, 46: 705-716, 1986.
2. Baeuerle, P. A., and Henkel, T. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol., 12: 141-179, 1994.
3. Baldwin, A. S., Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol., 14: 649-681, 1996.
4. Verma, I. M., Stevenson, J. K., Schwarz, E. M., Van Antwerp, D., and Miyamoto, S. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev., 9: 2723-2735, 1995.
5. Gilmore, T. D., Koedood, M., Piffat, K. A., and White, D. W. Rel/NF-κB/IκB protein and cancer. Oncogene, 13: 1367-1378, 1996.
6. DiDonato, J., Mercurio, F., Rosette, C., Wu-Li, J., Suyang, H., Ghosh, S., and Karin, M. Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation. Mol. Cell. Biol., 16: 1295-1304, 1996.
7. Chen, Z., Hagler, J., Palombella, V. J., Melandri, F., Scherer, D., Ballard, D., and Maniatis, T. Signal-induced site-specific phosphorylation targets IκBα to ubiquitin-proteasome pathway. Genes Dev., 9: 1586-1597, 1995.
8. Neiman, P. E., Thomas, S. J., and Loring, G. Induction of apoptosis during normal and neoplastic B-cell development in the bursa of Fabricius. Proc. Natl. Acad. Sci. USA, 88: 5857-5861, 1991.
9. White, D. W., Roy, A., and Gilmore, T. D. The v-Rel oncoprotein blocks apoptosis and proteolysis of IκB-α in transformed chicken spleen cells. Oncogene, 10: 857-868, 1995.
10. Wu, M., Lee, H., Bellas, R. E., Schauer, S. L., Arsura, M., Katz, D., FitzGerald, M. J., Rothstein, T. L., Sherr, D. H., and Sonenshein, G. E. Inhibition of NF-κB/Rel induces apoptosis of murine B cells. EMBO J., 15: 4682-4690, 1996.
11. Beg, A., and Baltimore, D. An essential role for NF-κB in preventing TNF-α induced cell death. Science (Washington DC), 274: 782-784, 1996.
12. Liu, Z., Hailing, H., Goeddel, D. V., and Karin, M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell, 87: 565-576, 1996.
13. Van Antwerp, D. J., Seamus, J. M., Kafri, T., Green, D., and Verma, I. Suppression of TNF-α-induced apoptosis by NF-κB. Science (Washington DC), 274: 787-789, 1996.
14. Wang, C-Y., Mayo, M. W., and Baldwin, A. S., Jr. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science (Washington DC), 274: 784-787, 1996.
15. Fausto, N., and Webber, E. M. Control of liver growth. Crit. Rev. Eukaryotic Gene Exp., 3: 117-135, 1993.
16. Tewari, M., Dobrzanski, P., Mohn, K. L., Cressman, D. E., Hsu, J-C., Bravo, R., and Taub, R. Rapid induction in regenerating liver of RL/IF-1 (an IκB that inhibits NF-κB, RelB-p50, and c-Rel-p50) and PHF, a novel κB site-binding complex. Mol. Cell. Biol., 12: 2898-2908, 1992.
17. FitzGerald, M. J., Webber, E. M., Donovan, J. R., and Fausto, N. Rapid DNA binding by nuclear factor κB in hepatocytes at the start of liver regeneration. Cell Growth Differ., 6: 417-427, 1995.
18. Cressman, D. E., Greenbaum, L. E., Haber, B. A., and Taub, R. Rapid activation of post-hepatectomy factor/nuclear factor κB in hepatocytes, a primary response in the regenerating liver. J. Biol. Chem., 269: 30429-30435, 1994.
19. Wu, J. C., Merlino, G., and Fausto, N. Establishment and characterization of differentiated, non transformed hepatocyte cell lines derived from mice transgenic for transforming growth factor α. Proc. Natl. Acad. Sci. USA, 91: 674-678, 1994.
20. Roberts, A. B., and Sporn, M. B. (eds.). The transforming growth factor-betas. In: Peptide Growth Factor and Their Receptors, pp. 419-472. Heidelberg, Germany: Springer-Verlag, 1990.
21. Massagué, J. The transforming growth factor-β family. Annu. Rev. Cell. Biol., 6: 597-641, 1990.
22. Stavnezer, J. Transforming growth factor beta regulation of B-cell proliferation, differentiation and class switching. In: C. M. Snapper (ed.), Cytokine Regulation of Humoral Immunity: Basic and Clinical Aspects, pp. 289-324. New York: Wiley and Sons, 1996.
23. Carr, B. I., Hayashi, I., Branum, E. L., and Moses, H. L. Inhibition of DNA synthesis in rat hepatocytes by platelet-derived type β transforming growth factor. Cancer Res., 46: 2330-2334, 1986.
24. McMahon, J. B., Richards, W. L., del Campo, A. A., Song, M-K. H., and Thorgeirsson, S.S. Differential effects of transforming growth factor-β on proliferation of normal and malignant rat liver epithelial cells in culture. Cancer Res., 46: 4665-4671, 1986.
25. Braun, L., Mead, J. E., Panzica, M., Mikumo, R., Bell, G. I., and Fausto, N. Transforming growth factor β mRNA increases during liver regeneration: a possible mechanism of growth regulation. Proc. Natl. Acad. Sci. USA, 85: 1539-1543, 1988.
26. Oberhammer, F. A., Pavelka, M., Sharma, S., Tiefenbacher, R., Purchio, A. F., Bursch, W., and Schulte-Hermann, R. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1. Proc. Natl. Acad. Sci. USA, 89: 5408-5412, 1992.
27. Sanderson, N., Factor, V., Nagy, P., Kopp, J., Kondaiah, P., Wakefield, L., Roberts, A. B., Sporn, M. B., and Thorgeirsson, S. S. Hepatic expression of mature transforming factor β1 in transgenic mice results in multiple tissue lesions. Proc. Natl. Acad. Sci. USA, 92: 2572-2576, 1995.
28. Russell, W. E., Coffey, R. J., Jr., Ouellette, A. J., and Moses, H. L. Type β transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat. Proc. Natl. Acad. Sci. USA, 85: 5126-5130, 1988.
29. Arsura, M., Wu, M., and Sonenshein, G. E. TGF-β1 inhibits NF-κB/Rel activity inducing apoptosis of B cells: transcriptional activation of IκB-α. Immunity, 5: 31-40, 1996.
30. Beg, A., Sha, W., Bronson, R., Ghosh, S., and Baltimore, D. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature (Lond.), 376: 167-170, 1995.
31. Duyao, M. P., Buckler, A. J., and Sonenshein, G. E. Interaction of an NF-κB-like factor with a site upstream of the c-myc promoter. Proc. Natl. Acad. Sci. USA, 87: 4727-4731, 1990.
32. Bellas, R. E., FitzGerald, M. J., Fausto, N., and Sonenshein, G. E. Inhibition of NF-κB activity induces apoptosis in murine hepatocytes. Am. J. Pathol., in press, 1997.
33. La Rosa, F. A., Pierce, J. W., and Sonenshein, G. E. Differential regulation of the c-myc oncogene promoter by the NF-κB Rel family of transcription factors. Mol. Cell. Biol., 14: 1039-1044, 1994.
34. Amicone, L., Spagnoli, F. M., Spath, G., Giordano, S., Tommasini, C., Bernardini, S., De Luca, V., Della Rocca, C., Weiss, M. C., Comoglio, P. M., and Tripodi, M. Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes. EMBO J., 16: 495-503, 1997.
35. Schulte-Hermann, R. Tumor promotion in the liver. Arch. Toxicol., 57: 147-158, 1985.
36. Oberhammer, F. A., Bursch, W., Parzefall, W., Breit, P., Erber, E., Stadler, M., and and Schulte-Hermann, R. Effect of transforming growth factor β on cell death of cultured rat hepatocytes. Cancer Res., 51: 2478-2485, 1991.
37. Krams, S. M., Egawa, H., Quinn, M. B., Villanueva, J. C., Garcia-Kennedy, R., and Martinez, O. M. Apoptosis as a mechanism of cell death in liver allograft rejection. Transplantation, 59: 621-625, 1995.
38. Yamada, Y., Kirillova, I., Peschon, J. J., and Fausto, N. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc. Natl. Acad. Sci. USA, 94: 1441-1446, 1997.
39. Suyang, H., Phillips, R., Douglas, I., and Ghosh, S. Role of unphosphorylated, newly synthesized IκBβ in persistent activation of NF-κB. Mol. Cell. Biol., 16: 5444-5449, 1996.
40. Barroga, C. F., Stevenson, E. M., Schwarz, E. M., and Verma, I. M. Constitutive phosphorylation of IκB-α by casein kinase II. Proc. Natl. Acad. Sci. USA, 92: 7637-7641, 1995.
41. Lee, H., Arsura, M., Wu, M., Duyao, M., Buckler, A. J., and Sonenshein, G. E. Role of Rel-related factors in control of c-myc gene transcription in receptor mediated apoptosis of the murine B cell WEHI 231 line. J. Exp. Med., 182: 1169-1177, 1995.
42. O'Farrell, P. H. High resolution two-dimensional electrophoresis of proteins. J. Biol. Chem., 10: 4007-4021, 1975.
43. Maheswaran, S., McCormack, J. E., and Sonenshein, G. E. Changes in phosphorylation of myc oncogens and RB antioncogene protein products during growth arrest of the murine lymphoma WEHI 231 cell line. Oncogene, 6: 1965-1971, 1991.