Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells

Cancer Letters

Volumn 146, Issue 1, 1999, Pages 35-44

  Melnyk, S ^a   Pogribna, M ^a   Miller, B J ^a   Basnakian, A G ^a   Pogribny, I P ^b   James, S J ^a,b  

^a US FDA Natl Ctr Toxicological R   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Cell transformation; Deoxynucleotides; DNA methylation; Folate deficiency; Gene amplification; Mutation; Uracil

Indexed keywords

URACIL;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL TRANSFORMATION; CONTROLLED STUDY; DNA METHYLATION; DNA REPAIR; DRUG DISTRIBUTION; FOLIC ACID DEFICIENCY; GENE AMPLIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MUTATION; NONHUMAN; OVARY CELL; PRIORITY JOURNAL; TUMOR GROWTH;

ANIMALS; ASPARTIC ACID; CELL DEATH; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CHO CELLS; CRICETINAE; DNA DAMAGE; FOLIC ACID DEFICIENCY; GENE AMPLIFICATION; MICE; MICE, INBRED BALB C; PHOSPHONOACETIC ACID; THYMINE NUCLEOTIDES; URACIL;

EID: 0032860818     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(99)00213-X     Document Type: Article

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