Viruses and apoptosis

International Journal of Experimental Pathology

Volumn 82, Issue 2, 2001, Pages 65-76

  Thomson, Brian J ^a,b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b NOTTINGHAM CITY HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; Cancer; Caspases; Death receptors; Mitochondria; Viruses

Indexed keywords

CASPASE; FAS ANTIGEN; GENE PRODUCT; PROTEIN P53;

APOPTOSIS; CARCINOGENESIS; CELL CYCLE; CELL DEATH; DIMERIZATION; HOMEOSTASIS; HOST CELL; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; REVIEW; SIGNAL TRANSDUCTION; VIRUS INFECTION;

ANIMALS; APOPTOSIS; CASPASES; CELL TRANSFORMATION, VIRAL; CYTOPATHOGENIC EFFECT, VIRAL; GENES, P53; HOST-PARASITE RELATIONS; HUMANS; MITOCHONDRIA; ONCOGENIC VIRUSES; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, TUMOR NECROSIS FACTOR; VIRAL PROTEINS;

EID: 0034919339     PISSN: 09599673     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2613.2001.00195.x     Document Type: Review

References (101)

1. The Bcl-2 protein family: Arbiters of cell survival
2. Death receptors: Signaling and modulation
3. ARF links the tumour suppressors RB and p53
4. Heat shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the apaf-1 apoptosome
5. Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis
6. Apoptosis. Mitochondria - The death signal integrators
7. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based-lymphomas
8. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma
9. A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerise with Bax or Bak
10. Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells
11. Control of programmed cell death by the baculovirus genes p35 and iap
12. An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif
13. The mitochondrial permeability transition pore and its role in cell death
14. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptotis
15. The inhibitor of death receptor signalling, FLICE-inhibitory protein defines a new class of tumor progression factors
16. Blockage by adenovirus E4 orf6 of transcriptional activation by the p53 tumor suppressor
17. The bfl-1 gene I transcriptionally upregulated by the Epstein-Barr virus LMP1-, and its expression promotes the survival of a Burkitt's lymphoma cell line
18. Smac, a mitochondrial protein that promotes cytochrome-c dependent caspase activation by eliminating IAP inhibition
19. A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors
20. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
21. Degradation of intracellular DNA in KB cells infected with cyt mutants of adenovirus-type-12
22. Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K
23. The ability of BHRF1 to inhibit apoptosis is dependent on stimulus and cell type
24. Epstein-Barr virus latent membrane protein 1 blocks p53-mediated apoptosis
25. Herpesvirus saimiri v FLIP provides an anti-apoptotic function but is not essential for viral replication, transformation or proliferation
26. Apoptotic pathways: The roads to ruin
27. Mitochondria and apoptosis
28. Activation of Epstein-Barr virus latent genes protects human-B cells from death by apoptosis
29. Identification of a subset of normal B cells with a Burkitt's lymphoma (BL)-like phenotype
30. Bax is frequently compromised in Burkitt's lymphomas with irreversible resistance to Fas-induced apoptosis
31. Interaction of E1B 19K with Bax is required to block Bax-induced loss of mitochondrial membrane potential and apoptosis
32. The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53 inducible and death-promoting Bax protein
33. Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic location distinct from Bcl-2 or Bcl-x (L)
34. Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B-cells from programmed cell death
35. Induction of Bcl-2 expression by Epstein-Barr virus latent membrane protein-1 protects infected B cells from programmed cell death
36. Herpes simplex and "the herpes complex": Diverse observations and a unifying hypothesis. The eighth Fleming lecture
37. A novel family of death effector domain-containing molecules that inhibit both CD-95 and tumor necrosis factor receptor-1-induced apoptosis
38. WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation
39. Bcl-2/E1B 19 Kda-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability
40. Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to apaf-1
41. Molecular and cellular mechanisms regulating T and B cell apoptosis through Fas/FasL interaction
42. Role of the Fas/Fas ligand apoptotic pathway in human immunodeficiency virus type 1 disease
43. Apoptosis: A basic biological phenomenon with wide ranging implication in tissue kinetics
44. BHRF1, a viral homologue of the Bcl-2 oncogene, is conserved at both the sequence and functional level in different Epstein-Barrr virus isolates
45. CD95's deadly mission in the immune system
46. The adenovirus type 3 E1B-55K oncoprotein is a highly active shuttle protein and shuttling is independent of E4 orf6, p53 and MDM-2
47. Mitochondrial control of cell death
48. Cytochrome c release and apoptosis induced by mitochondrial targeting of a nuclear orphan receptor TR3
49. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
50. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
51. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
52. Expression of the Epstein-Barr virus BHRF1 gene, a homologue of Bcl-2, in nasopharyngeal carcinoma tissue
53. Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain
54. Death signal-induced localisation of p53 to mitochondria. A potential role in apoptosis signalling
55. Epstein-Barr virus encodes a novel homolog of the bcl-2 oncogene that inhibits apoptosis and associates with Bax and Bak
56. Adenovirus E1B-55K represses p53 activation in vitro
57. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis
58. Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein
59. Immortalisation of human T cells by herpesvirus saimiri
60. Bcl-2 family members do not inhibit apoptosis by binding the caspase activator apaf-1
61. X-ray and NMR studies of human Bcl-xL, an inhibitor of programmed cell death
62. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
63. Bcl-xL does not inhibit the function of Apaf-1
64. Expression of CD95 antigen and Bcl-2 protein in non-Hodgkin's lymphomas and Hodgkin's disease
65. p19ARF links the tumour suppressor p53 to Ras
66. Negative regulation of cytochrome c-mediated oligomerization of apaf-I and activation of procaspase-9 by heat shock protein 90
67. Mdm2: Keeping p53 under control
68. Tumor B cells from non-Hodgkin's lymphoma are resistant to CD95 (Fas/Apo-1) -mediated apoptosis
69. The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells
70. Expansion or elimination of B cells in vivo: Dual roles for CD40- and Fas (CD95) -ligands modulated by the B cell antigen receptor
71. Epstein-Barr virus
72. Caspase-9 and APAF-1 form an active holoenzyme
73. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells
74. Cytochrome c and dATP-mediated oligomerisation of Apaf-1 is a prerequisite for procaspase-9 activation
75. Transcription mapping of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) genome in body cavity-based lymphoma cell line (BC-1)
76. Kaposi's sarcoma-associated herpesvirus encodes a functional Bcl-2 homologue
77. Two CD95 (APO-1/Fas) signalling pathways
78. Differential modulation of apoptosis sensitivity in CD95 type I and type II cells
79. The E6 oncoprotein encoded by human papillomavirus type-16 and type-18 promotes the degradation of p53
80. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
81. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations
82. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease
83. p53-independent apoptotic and necrotic cell deaths induced by adenovirus infection: Suppression by E1B 19K and Bcl-2 proteins
84. Mitochondrial release of caspases-2 and -9 during the apoptosis process
85. P19 (ARF) stabilises p53 by blocking nucleo-cytoplasmic shuttling of Mdm2
86. Transcriptional analysis of human herpesvirus-8 open reading frames 71, 72, 73, K14, 74 in a primary effusion lymphoma cell line
87. Epstein-Barr virus BHRF1 protein protects against cell death induced by DNA-damaging agents and heterologous viral infection
88. Modulation of caspase-8 and FLICE-inhibitory protein expressions as a potential mechanism of Epstein-Barr virus tumorigenesis in Burkitt's lymphoma
89. The role of the E6-53 interaction in the molecular pathogenesis of HPV
90. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death recptors
91. Apoptosis in the pathogenesis and treatment of disease
92. Forced degradation of Fas inhibits apoptosis in adenovirus-infected cells
93. B-cell apoptosis induced by antigen receptor cross-linking is blocked by a T cell signal through CD40
94. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and recognising IAP proteins
95. Surfing the p53 network
96. Apoptosis. Placing death under control
97. Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses
98. Expression and function of Fas during differentiation and activation of B cells
99. Structural basis for IAP recognition by Smac/DIABLO
100. Apoptosis is induced at nonpermissive temperature by a transient increase in p53 in cell-lines immortalised with temperature sensitive SV40 large T-antigen gene
101. Adenovirus E1B 19K/BCL-2 interacting protein BNIP3 contains a mitochondrial targeting sequence