Nutrient sensing, leptin and insulin action

Archives of Physiology and Biochemistry

Volumn 109, Issue 1, 2001, Pages 38-51

  Ukropec, J ^a   Sebokova E ^a   Klimes I ^a  

^a INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

Author keywords

Diet induced insulin resistance; Fatty acid oxidation; Fish oil; Hexosamine pathway; Insulin action; Leptin; Malonyl CoA hypothesis

Indexed keywords

INSULIN; LEPTIN;

ADIPOCYTE; FATTY ACID OXIDATION; HUMAN; INSULIN RESISTANCE; OBESITY; PATHOPHYSIOLOGY; REVIEW;

ANIMALS; DIETARY FATS; EATING; ENERGY METABOLISM; FISH OILS; HEXOSAMINES; HUMANS; INSULIN; LEPTIN; MICE; MODELS, BIOLOGICAL; RATS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0034914291     PISSN: 13813455     EISSN: None     Source Type: Journal    
DOI: 10.1076/apab.109.1.38.4284     Document Type: Review

References (132)

1. Short-term, high-fat diets lower circulating leptin concentrations in rats
2. Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones
3. Coordinate induction of peroxisomal acyl-CoA oxidase and UCP-3 by dietary fish oil: A mechanism for decreased body fat deposition
4. Genetics of bodyweight regulation
5. Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action
6. Leptin selectively decreases visceral adiposity and enhances insulin action
7. 3-Adrenergic receptor gene related to non-insulin-dependent Diabetes mellitus and juvenile hypertension in the Czech population?
8. Regulation of rat liver apolipoprotein A-I, apolipoprotein A-II and acyl-CoA oxidase gene expression by fibrates and dietary fatty acids
9. 2+-mobilizing hormones: Studies using phospholipase C and phorbol myristate acetate
10. Upregulation of Blood-brain barrier short-form leptin receptor gene products in rats fed a high fat diet
11. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha
12. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
13. Recombinant mouse OB protein: Evidence for peripheral signal linking adiposity and central neural networks
14. Modulation of insulin secretion by leptin
15. Comparing effects of leptin and insulin on glucose metabolism in skeletal muscle: Evidence for an effect of leptin on glucose uptake and decarboxylation
16. Dietary fat type and energy restriction interactively influence plasma leptin concentration in rats
17. Leptin restores euglycemia and normalises glucose turnover in insulin-deficient diabetes in the rat
18. Glucosamine regulation of glucose metabolism in cultured human skeletal muscle cells: Divergent effects on glucose transport/phosphorylation and glycogen synthase in non-diabetic and type 2 diabetic subjects
19. 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity
20. Modulation of insulin activities by leptin
21. Nutritional regulation of leptin in humans
22. Role of leptin in fat regulation
23. 3 adrenergic receptor
24. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
25. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion
26. On the mechanism of induction of the enzyme systems for peroxisomal beta oxidation of fatty acids in rat liver by diets rich in partially hydrogenated fish oil
27. Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
28. Leptin expression and action: New experimental paradigms
29. Leptin levels reflect body lipid content in mice: Evidence for diet induced resistance to leptin action
30. Leptin: A potent inhibitor of insulin secretion
31. Leptin and the regulation of body weight in mammals
32. Leptin: Physiology and pathophysiology
33. Transcriptional regulation of fatty acid synthase by glucose/insulin, polyunsaturated fatty acid and leptin in hepatocytes and adipocytes in normal and genetically obese rats
34. Glucose transport and insulin signalling in rat muscle and adipose tissue: Effect of lipid availability
35. 3adrenoceptor agonist, reduces serum leptin in rats with diet- or ageing-associated obesity, but not in Zucker rats with genetic (fa/fa) obesity
36. Cloning and characterisation of an uncoupling protein homolog
37. 3adrenergic agonist, up-regulates muscle uncoupling protein-3 messenger RNA expression: Short-term thermogenic interactions
38. Weight reducing effects of the plasma protein encoded by the obese gene
39. Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats
40. Dietary omega-3 fatty acids prevent carbohydrate-induced hypertriglyceridemia
41. Initiation of hyperinsulinemia and hyperleptinemia is diet dependent in C57BL/6 mice
42. Role of the glucosamine pathway in fat-induced insulin resistance
43. 3 AR agonist on energy balance in brown and white adipose tissue in rats
44. Regulation of sterol regulatory element binding proteins in livers of fasted and re-fed mice
45. Increased uncoupling protein 2 mRNA in white adipose tissue, and decrease in leptin, visceral fat, blood glucose, and cholesterol in KK-Ay mice fed with eicosapentaenoic and docosahexaenoic acids in addition to linoleic acid
46. Gene expressions of leptin, insulin receptors and lipogenic enzymes are coordinately regulated by insulin and dietary fat in rats
47. Immunological analysis of acetyl-CoA carboxylase mass, tissue distribution and subunit composition
48. Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids
49. Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets
50. Acute stimulation of glucose metabolism in mice by leptin treatment
51. Leptin receptors expressed on pancreatic beta cells
52. + canals in pancreatic β-cells
53. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
54. Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs
55. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma
56. Dietary omega-3 fatty acids and insulin binding and action in liver and adipose tissue of normal and hereditary hypertriglyceridemic rats fed a high sucrose diet
57. Raised dietary intake of n-3 polyunsaturated fatty acids in high sucrose-induced insulin resistance. Animal studies
58. Obesity as a medical problem
59. Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats
60. Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991
61. Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice
62. 3adrenergic regulation of leptin, food intake, and adiposity is impaired with age
63. Malonyl coenzyme A and adiposity in the Dahl salt-sensitive rat: Effects of pioglitazone
64. Activation of protein kinase Cε may contribute to muscle insulin resistance induced by lipid accumulation during chronic glucose infusion in rats
65. Failure of human and mouse leptin to affect insulin, glucagon and somatostatin secretion by the perfused rat pancreas at physiological glucose concentrations
66. Development of high fat diet induced obesity and leptin resistance in C57B1/6J mice
67. The effects of a high fat diet on leptin mRNA, serum leptin and the response to leptin are not altered in a rat strain susceptible to high fat diet-induced obesity
68. Long-term administration of sucrose-rich diet to normal rats: Relationship between metabolic and hormonal profiles and morphological changes in the endocrine pancreas
69. Towards a molecular understanding of adaptive thermogenesis
70. Effect of acute or prolonged exposure to human leptin on isolated human islet function
71. Eicosapentaenoic and docosahexaenoic acid affect mitochondrial and peroxisomal fatty acid oxidation in relation to substrate preference
72. 3adrenergic receptor suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice
73. Discovery of a metabolic pathway mediating glucose induced desensitisation of the glucose transport system: Role of hexosamine biosynthesis in the induction of insulin resistance
74. Regulation of energy balance and adiposity: A model with a new approaches
75. Hexosamines stimulate leptin production in transgenic mice
76. Hexosamine and insulin resistance
77. A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis
78. Observations of the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase-I in an animal and human tissues. Demonstration of the presence of malonyl-CoA in non-hepatic tissues of the rat
79. Monosaccharide-enriched diets cause hyperleptinemia without hypophagia
80. Leptin directly alters lipid partitioning in skeletal muscle
81. Thermogenic mechanism in brown fat
82. Metabolic aspects of peroxisomal beta-oxidation
83. Skeletal muscle triglyceride levels are inversely related to insulin action
84. Dietary lipid profile is a determinant of tissue phospholipid fatty acid composition and rate of weight gain in rats
85. Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signalling events in skeletal muscle
86. Glucose-induced phosphorylation of the insulin receptor
87. Menhaden oil prevents but does not reverse sucrose-induced insulin resistance
88. Dietary fatty acids influence the activity and metabolic control of mitochondrial carnitine palmitoyltransferase I in rat heart and skeletal muscle
89. Are the β-cell signalling molecules malonyl-CoA and cytosolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?
90. Site-specific regulation of gene expression by n-3 polyunsaturated fatty acids in rat white adipose tissue
91. Control of the tricarboxylate cycle and its interactions with glycolysis during acetate utilisation in rat heart
92. The glucose-fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
93. Mechanisms modifying glucose oxidation in diabetes mellitus
94. Regulation of fatty acid oxidation in skeletal muscle
95. Role of insulin resistance in human disease
96. Reduction of leptin gene expression by dietary polyunsaturated fatty acids
97. Long-term exposure of β-INS cells to high glucose concentrations increases anaplerosis, lipogenesis and lipogenic gene expression
98. Perspective: Hexosamine and nutrient sensing
99. In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats
100. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action
101. Interaction between ketone-body and carbohydrate metabolism in peripheral tissue
102. Lipid abnormalities in muscle of insulin resistant rodents: The malonyl-CoA hypothesis
103. Malonyl-CoA fuel sensing and insulin resistance
104. A malonyl-CoA fuel sensing mechanism in muscle effects of insulin, glucose and denervation
105. Cytosolic citrate and malonyl-CoA regulation in rat muscle in vivo
106. Malonyl-CoA regulation in skeletal muscle: Its link to cell citrate and the glucose-fatty acid cycle
107. Leptin increases uncoupling protein expression and energy expenditure
108. Alterations in the expression and cellular localisation of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat
109. Regulation of gene expression for lipogenic enzymes in the liver and adipose tissue of hereditary hypertriglyceridemic, insulin resistant rats: Effect of dietary sucrose and marine fish oil
110. Hypotriglyceridemic effect of fish oil is associated with decreased leptin expression
111. Direct antidiabetic effect of leptin through triglyceride depletion of tissues
112. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
113. Sterol regulatory element binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
114. Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver
115. The hormone of resistin links obesity to diabetes
116. Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure and obesity in the rat
117. Influence of dietary fat composition on development of insulin resistance in rats: Relationship to muscle triglyceride and ω-3 fatty acids in muscle phospholipids
118. Fish oil prevents insulin resistance induced by high fat feeding in rats
119. Effects of sucrose vs. starch diets on in vivo insulin action, thermogenesis, and obesity in rats
120. Effects of fructose and glucose on plasma leptin, insulin and insulin resistance in lean and VMH-lesioned obese rats
121. Copper deficiency induces hepatic fatty acid synthase gene transcription in rats by increasing the nuclear content of mature sterol regulatory element binding protein 1
122. Direct stimulation of basal insulin secretion by physiological concentrations of leptin in pancreatic β-cells
123. Decreased leptin expression is associated with hypotriglyceridemic effect of fish oil
124. Regulation of fatty acid homeostasis in cells: Novel role of leptin
125. UCP-3: An uncoupling protein homolog expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
126. Metabolic effects of high sucrose of fructose intake
127. Nutrients and glucose homeostasis: Effects of the type of dietary carbohydrates and the n-3 fatty acids on insulin secretion and action
128. Novel form of lipolysis induced by leptin
129. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
130. A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids
131. Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker diabetic fatty rats: Role in the pathogenesis of lipotoxic diabetes
132. Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes