Human cytomegalovirus and natural killer-mediated surveillance of HLA class I expression: A paradigm of host-pathogen adaptation

Immunological Reviews

Volumn 181, Issue , 2001, Pages 193-202

  López Botet, Miguel ^a   Llano, Manuel ^b   Ortega, Mara ^b  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CD94 ANTIGEN; CELL SURFACE RECEPTOR; HLA ANTIGEN CLASS 1; IMMUNOGLOBULIN RECEPTOR; LECTIN; RECEPTOR NKG2A; UNCLASSIFIED DRUG;

ADAPTATION; ANTIGEN PRESENTATION; BIOSYNTHESIS; CYTOMEGALOVIRUS; HOST; IMMUNE RESPONSE; IMMUNE SYSTEM; MAJOR HISTOCOMPATIBILITY COMPLEX; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN INTERACTION; REVIEW; T LYMPHOCYTE;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; CYTOMEGALOVIRUS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; KILLER CELLS, NATURAL; MICE; RECEPTORS, IMMUNOLOGIC; VIRAL PROTEINS;

EID: 0034895023     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2001.1810116.x     Document Type: Review

References (102)

1. Immune inhibitory receptors
2. HLA class I specific inhibitory receptors
3. NK cell receptors
4. Regulation of immune responses through inhibitory receptors
5. Natural killer cell activation and inhibition by receptors for MHC class I
6. Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis
7. Natural killer cells in antiviral defense: Function and regulation by innate cytokines
8. Viral mechanisms of immune evasion
9. Viral subversion of the immune system
10. Development and tolerance of natural killer cells
11. Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans
12. NK cell recognition of non-classical HLA class I molecules
13. Receptors for HLA class-I molecules in human natural killer cells
14. NK cells, MHC class I antigens, and missing self
15. A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors
16. Plasticity in the organization and sequences of human KIR/ILT families
17. Genomic organization and allelic polymorphism of the human killer cell inhibitory receptor gene KIR103
18. Human diversity in killer cell inhibitory receptor genes
19. The binding site of NK receptors on HLA-C molecules
20. Conserved and variable residues within the Bw4 motif of HLA-B make separable contributions to recognition by the NKB1 killer cell-inhibitory receptor
21. A single amino acid in the p58 killer cell inhibitory receptor controls the ability of natural killer cells to discriminate between the two groups of HLA-C allotypes
22. Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors
23. Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors
24. Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I
25. Crystal structure of the HLA-Cw3 allotype-specific killer cell inhibitory receptor KIR2DL2
26. Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand
27. Signal transduction during natural killer cell activation: Inside the mind of a killer
28. Immunoreceptor tyrosine-based inhibition motifs
29. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells
30. Role of amino acid position 70 in the binding affinity of p50.1 and p58.1 receptors for HLA-Cw4 molecules
31. Differential binding to HLA-C of p50-activating and p58-inhibitory natural killer cell receptors
32. Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: Structural evidence for new stimulatory and inhibitory pathways
33. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells
34. A novel family of inhibitory receptors for HLA class I molecules that modulate function of lymphoid and myeloid cells
35. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules
36. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules
37. Isotypic variation of novel immunoglobulin-like transcript/killer cell inhibitory receptor loci in the leukocyte receptor complex
38. Human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor γ-chain
39. Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules
40. The ILT2 (LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells
41. The leukocyte Ig-like receptor (LIR)-1 for the cytomegalovirus UL18 protein displays a broad specificity for different HLA class I alleles: Analysis of LIR-1 +NK cell clones
42. Identification of the CD85 antigen as ILT2, an inhibitory MHC class I receptor of the immunoglobulin super family
43. The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes
44. Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2)
45. The CD94/NKG2 C-type lectin receptor complex
46. Structure of the human CD94 C-type lectin gene
47. Specific engagement of the CD94/NKG2A killer inhibitory receptor by the HLA-E class Ib molecule induces SHP-1 phosphatase recruitment to tyrosine-phosphorylated NKG2A: Evidence for receptor function in heterologous transfectants
48. Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: Association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases
49. CD94/NKG2-A inhibitory complex blocks CD16-triggered Syk and extracellular regulated kinase activation, leading to cytotoxic function of human NK cells
50. The activating form of CD94 receptor complex: CD94 covalently associates with the Kp39 protein that represents the product of the NKG2-C gene
51. Mitogen-activated protein kinase activity is involved in effector functions triggered by the CD94/NKG2-C NK receptor specific for HLA-E
52. + T cell clone upon the aggregation of an activatory CD94/kp39 heterodimer
53. Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis
54. HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A
55. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
56. HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences
57. The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9
58. TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide
59. Specific recognition of HLA-E, but not classical, HLA class I molecules by soluble CD94/NKG2A and NK cells
60. Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E
61. Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells
62. Two genes in the rat homologous to human NKG2
63. Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independendy in natural killer cells
64. Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells
65. Molecular characterization of a gene in the rat homologous to human CD94
66. Cloning of murine NKGZA, B and C: Second family of C-type lectin receptors on murine NK cells
67. b
68. The Qa-1b molecule binds to a large subpopulation of murine NK cells
69. The pathway for processing leader-derived peptides that regulate the maturation and expression of Qa-1b
70. Dominance of a single peptide bound to the class I(B) molecule, Qa-1b
71. HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: Preferential response to an HLA-G-derived nonamer
72. Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E
73. Viral effects on antigen processing
74. The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP
75. A viral ER-resident glycoprotein inactivates the MHC-encoded peptide transporter
76. Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains
77. Human cytomegalovirus inhibits antigen presentation by a sequential multistep process
78. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol
79. The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products
80. The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
81. Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules
82. The HCMV gene products US11 and US2 differ in their ability to attack allelic forms of murine major histocompatibility complex (MHC) class I heavy chains
83. Human cytomegalovirus gene products US3 and US6 down-regulate trophoblast class I MHC molecules
84. Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11
85. A role for MHC class I down-regulation in NK cell lysis of herpes virus-infected cells
86. Interaction of HLA-E with peptides and the peptide transporter in vitro: Implications for its function in antigen presentation
87. Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40
88. The human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis
89. Cell surface expression of HLA-E molecules on PBMC from a TAP1-deficient patient
90. Implications of HLA-E allele expression and different HLA-E ligand diversity for the regulation of NK cells
91. Molecular studies and NK cell function of a new case of TAP2 homozygous human deficiency
92. Paired inhibitory and triggering NK cell receptors for HLA class I molecules
93. The Cmv1 host resistance locus is closely linked to the Ly49 multigene family within the natural killer cell gene complex on mouse chromosome 6
94. The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18
95. The class I MHC homologue of human cytomegalovirus inhibits attack by natural killer cells
96. Modulation of natural killer cell cytotoxicity in human cytomegalovirus infection: The role of endogenous class I major histocompatibility complex and a viral class I homolog
97. Inhibition of natural killer cells by a cytomegalovirus MHC class I homologue in vivo
98. Human cytomegalovirus strain-dependent changes in NK cell recognition of infected fibroblasts
99. Activation of NK Cells and T cells by NKG2D, a receptor for stress-inducible MICA
100. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice
101. Role of NKG2D in tumor cell lysis mediated by human NK cells: Cooperation with natural cytotoxicity receptors and capability of recognizing tumors of nonepithelial origin
102. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor