Cutting edge: Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I-molecules

Journal of Immunology

Volumn 160, Issue 7, 1998, Pages 3096-3100

  Colonna, Marco ^a   Samaridis, Jacqueline ^a   Cella, Marina ^a   Angman, Lena ^a   Allen, Rachel L ^b   O'Callaghan, Chris A ^b   Dunbar, Rod ^b   Ogg, Graham S ^b   Cerundolo, Vincenzo ^b   Rolink, Antonius ^a  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; HLA ANTIGEN; HLA ANTIGEN CLASS 1; IMMUNOGLOBULIN RECEPTOR; LILRB2 PROTEIN, HUMAN; MEMBRANE PROTEIN; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; PTPN6 PROTEIN, HUMAN; PTPN6 PROTEIN, MOUSE; PTPN6 PROTEIN, RAT; SEROTONIN; SEROTONIN ANTAGONIST; SIGNAL PEPTIDE; SRC HOMOLOGY 2 (SH2) DOMAIN CONTAINING PHOSPHATASES; SRC HOMOLOGY-2 (SH2) DOMAIN-CONTAINING PHOSPHATASES;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DENDRITIC CELL; IMMUNE RESPONSE; LEUKOCYTE ACTIVATION; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MONOCYTE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; ANIMAL; B LYMPHOCYTE; BIOSYNTHESIS; CELL CULTURE; CELL LINE; ENZYMOLOGY; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MACROPHAGE ACTIVATION; MAST CELL; METABOLISM; MOLECULAR WEIGHT; PHYSIOLOGY; PROTEIN BINDING; RAT; SIGNAL TRANSDUCTION; WISTAR RAT;

ANIMALS; B-LYMPHOCYTES; CELL LINE; CELLS, CULTURED; DENDRITIC CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MACROPHAGE ACTIVATION; MACROPHAGES; MAST CELLS; MEMBRANE GLYCOPROTEINS; MICE; MOLECULAR WEIGHT; MONOCYTES; PROTEIN BINDING; PROTEIN-TYROSINE-PHOSPHATASE; RATS; RATS, WISTAR; RECEPTORS, IMMUNOLOGIC; SEROTONIN; SEROTONIN ANTAGONISTS; SHP1 PROTEIN TYROSINE PHOSPHATASE; SIGNAL TRANSDUCTION;

EID: 0032036434     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.160.7.3096     Document Type: Article

References (16)

1. Ljunggren, H. G., and K. Karre. 1990. In search of the "missing self": MHC molecules and NK cell recognition. Immunol. Today 11:237.
2. Yokoyama, W. M., and W. E. Seaman. 1993. The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annu. Rev. Immunol. 11:613.
3. Lanier, L. L. 1997. Natural killer cells: from no receptors to too many. Immunity 6:371.
4. Vivier E., and M. Daeron. 1997. Immunoreceptor tyrosine-based inhibition motifs. Immunol. Today 18:286.
5. Yokoyama, W. M. 1997. What goes up must come down: the emerging spectrum of inhibitory receptors. J. Exp. Med. 186:1803.
6. Samaridis, J., and M. Colonna. 1996. Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. Eur. J. Immunol. 27:660.
7. Cosman D., N. Fanger, L. Borges, M. Kubin, W. Chin, L. Peterson, and M. L. Hsu. 1997. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity 7:273.
8. Colonna, M., F. Navarro, T. Bellón, M. Llano, P. García, J. Samaridis, L. Angman, M. Cella, and M. López-Botet. 1997. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J. Exp. Med. 186:1809.
9. Cella, M., C. Dohring, J. Samaridis, M. Dessing, M. Brockhaus, A. Lanzavecchia, and M. Colonna. 1997. A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J. Exp. Med. 185:1743.
10. Lane P., C. Burdet, F. McConnell, A. Lanzavecchia, and E. Padovan. 1995. CD40 ligand-independent B cell activation revealed by CD40 ligand-deficient T cell clones: evidence for distinct activation requirements for antibody formation and B cell proliferation. Eur. J. Immunol. 6:1788.
11. Altman J. D., P. A. H. Moss, P. J. R. Goulder, D. H. Barouch, M. G. McHeyzer-Williams, J. I. Bell, A. J. McMichael, and M. M. Davis. 1996. Phenotypic analysis of antigen-specific T lymphocytes. Science 274:94.
12. Weltzien, H. U., H. P. Matthiessen, M. Meyer-Delius, F. Zimmermann, and E. Rude. 1984. Acidic "peptidophospholipids," a new class of hapten-bearing cell surface modifying reagents. Mol. Immunol. 21:801.
13. Kiener P. A., B. M. Rankin, A. L. Burkhardt, G. L. Schieven, L. K. Gilliland, R. B. Rowley, J. B. Bolen, and J. A. Ledbetter. 1993. Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase. J. Biol. Chem. 268: 24442.
14. Cella, M., F. Sallusto, and A. Lanzavecchia. 1997. Origin, maturation and antigen presenting function of dendritic cells. Curr. Opin. Immunol. 9:10.
15. Philip, R., and L. B. Epstein. 1986. Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, gamma-interferon and interleukin-1. Nature 323:86.
16. Ortaldo, J. R., L. H. Mason, B. J. Mathieson, S. M. Liang, D. A. Flick, and R. B. Herberman. 1986. Mediation of mouse natural cytotoxic activity by tumour necrosis factor. Nature 321:700.