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This paper reports that HCMV inhibits IFN-γ-stimulated MHC class II expression at the level of JAK/STAT signal transduction. There is an associated decrease in Jak1 protein.
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Miller DM, Rahill BM, Boss JM, Lairmore MD, Durbin JE, Waldman WJ, Sedmak DD Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway. J Exp Med. 187:1998;675-683. This paper reports that HCMV inhibits IFN-γ-stimulated MHC class II expression at the level of JAK/STAT signal transduction. There is an associated decrease in Jak1 protein.
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Murine cytomegalovirus inhibits interferon-γ-induced antigen presentation to CD4 T cells by macrophages via regulation of expression of major histocompatibility complex class II-associated genes
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This paper reports that MCMV blocks IFN-γ-stimulated MHC class II expression without affecting JAK/STAT signal transduction.
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Heise MT, Connick M, Virgin HW Murine cytomegalovirus inhibits interferon-γ-induced antigen presentation to CD4 T cells by macrophages via regulation of expression of major histocompatibility complex class II-associated genes. J Exp Med. 187:1998;1-10. This paper reports that MCMV blocks IFN-γ-stimulated MHC class II expression without affecting JAK/STAT signal transduction.
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Leonard GT, Sen GC Restoration of interferon responses of adenovirus E1A-expressing HT1080 cell lines by overexpression of p48 protein. J Virol. 71:1997;5095-5101.
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Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10
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Zeidler R, Eissner G, Meissner P, Uebel S, Tampe R, Lazis S, Hammerschmidt W Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10. Blood. 90:1997;2390-2397.
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