The activating form of CD94 receptor complex: CD94 covalently associates with the Kp39 protein that represents the product of the NKG2-C gene

European Journal of Immunology

Volumn 28, Issue 1, 1998, Pages 327-338

  Cantoni, Claudia ^a   Biassoni, Roberto ^a   Pende, Daniela ^a   Sivori, Simona ^b   Accame, Laura ^a   Pareti, Laura ^a   Semenzato, Gianpietro ^c   Moretta, Lorenzo ^a,b   Moretta, Alessandro ^b,d   Bottino, Cristina ^a  

^a CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

^d UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Activating receptor; CD94 complex; Human NK cell; NKG2 C

Indexed keywords

CD94 ANTIGEN; GLYCOPROTEIN; HLA ANTIGEN CLASS 1; LYMPHOCYTE RECEPTOR; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOLYSIS; HUMAN; HUMAN CELL; IMMUNOGENETICS; IMMUNOPRECIPITATION; NATURAL KILLER CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0031974596     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199801)28:01<327::AID-IMMU327>3.0.CO;2-O     Document Type: Article

References (38)

1. Moretta, A., Bottino, C., Vitale, M., Pende, D., Biassoni, R., Mingari, M. C. and Moretta, L., Receptors for HLA-class I molecules in human Natural Killer cells. Annu. Rev. Immunol. 1996. 14: 619-648.
2. Moretta, A., Biassoni, R., Bottino, C., Pende, D., Vitale, M., Poggi, A., Mingari, M. C. and Moretta, L., Major histocompatibility complex Class I-specific receptors on human Natural Killer and T lymphocytes, Immunol. Rev. 1997. 155: 105-117.
3. Moretta, A., Vitale, M., Bottino, C., Orengo, A. M., Morelli, L., Augugliaro, R., Barbaresi, M., Ciccone, E. and Moretta, L., P58 molecules as putative receptors for MHC class I molecules in human Natural Killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities. J. Exp. Med. 1993. 178: 597-604.
4. Vitale, M., Sivori, S., Pende, D., Moretta, L. and Moretta, A., The coexpression of two functionally independent p58 inhibitory receptors in human NK cell clones results in the inability to kill all normal allogeneic target cells. Proc. Natl. Acad. Sci. USA 1995. 92: 3536-3540.
5. Moretta, A., Bottino, C. and Biassoni, R., CD158a (p58.1/p50.1) and CD158b (p58.2/p50.2) NK receptors for HLA-C alleles. In: Kishimoto, T., (Ed) Abstracts of the VI International Workshop and Conference on Human Leukocyte Differentiation Antigens Japan 1996. Garland Press, London 1997, in press.
6. Vitale, M., Sivori, S., Pende, D., Augugliaro, R., Di Donato, C., Amoroso, A., Malnati, M., Bottino, C., Moretta, L. and Moretta, A., Physical and functional independency of p70 and p58 NK cell receptors for HLA-Class I. Their role in the definition of different groups of alloreactive NK cell clones. Proc. Natl. Acad. Sci. USA 1996. 93: 1453-1457.
7. Litwin, V., Gumperz, J. E., Parham, P., Phillips, J. H. and Lanier, L. L., NKB1: a Natural Killer cell receptor involved in the recognition of polymorphic HLA-B molecules. J. Exp. Med. 1994. 180: 537-543.
8. Pende, D., Biassoni, R., Cantoni, C., Verdiani, S., Falco, M., Di Donato, C., Accame, L., Bottino, C., Moretta, A. and Moretta, L., The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors which is charactericed by thee lg-like domains and is expressed as a 140-kD disulphide-linded dimer. J. Exp. Med. 1996. 184: 505-518.
9. Dohring, C., Scheidegger, D., Samaridis, J., Cella, M. and Colonna, M., A human killer inhibitory receptor specific for HLA-A. J. Immunol. 1996. 156: 3098-3101.
10. Long, E., Colonna, M. and Lanier, L. L., Inhibitory MHC class I receptors on NK and T cells: a standard nomenclature, Immunol. Today 1996. 17: 100.
11. Colonna, M. and Samaridis, J., Cloning of immunoglobulin superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 1995. 268: 405-408.
12. Wagtmann, N., Biassoni, R., Cantoni, C., Verdiani, S., Malnati, M. S., Vitale, M., Bottino, C., Moretta, L., Moretta, A. and Long, E. O., Molecular clones of the p58 NK cell receptor reveal immunoglobulin related molecules with diversity in both the extra- and intracellular domains. Immunity 1995. 2: 439-449.
13. D'Andrea, A., Chang, C., Franz-Bacon, K., McClanahan, T., Phillips, J. H. and Lanier, L. L., Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes. J. Immunol. 1995. 155: 2306-2310.
14. Burshtyn, D. N., Scharenberg, A. M., Wagtmann, N., Rajagopalan, S., Berrada, K., Yi, T., Kinet, J. P. and Long, E. O., Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor. Immunity 1996. 4: 77-85.
15. Olcese, L., Lang, P., Vély, F., Cambiaggi, A., Marguet, D., Bléry, M., Hippen, K. L., Biassoni, R., Moretta, A., Moretta, L., Gambier, J. C. and Vivier, E. J., Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor. J. Immunol. 1996. 156: 4531-4534.
16. Fry, A. M., Lanier, L. L. and Weiss, A., Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signalling and for association with protein tyrosine phosphatase 1C. J. Exp. Med. 1996. 184: 295-300.
17. Campell, K. S., Dessing, M., Lopez-Botet, M., Cella, M. and Colonna, M., Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein phosphatase 1C. J. Exp. Med. 1996. 184: 93-100.
18. Moretta, A., Sivori, S., Vitale, M., Pende, D., Morelli, L., Augugliaro, R., Bottino, C. and Moretta, L., Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human Natural Killer cells. J. Exp. Med. 1995. 182: 875-884.
19. Biassoni, R., Cantoni, C., Falco, M., Verdiani, S., Bottino, C., Vitale, M., Conte, R., Poggi, A., Moretta, A. and Moretta, L., The HLA-C-specific "activatory" or "inhibitory" Natural Killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. J. Exp. Med. 1996. 183: 645-650.
20. Olcese, L., Cambiaggi, A., Semenzato, G., Bottino, C., Moretta, A. and Vivier, E., Human killer cell activatory receptors for MHC class I molecules are included in a multimeric complex expressed by Natural Killer cells. J. Immunol. 1997. 158: 5083-5086.
21. Bottino, C., Sivori, S., Vitale, M., Cantoni, C., Falco, M., Pende, D., Morelli, L., Augugliaro, R., Semenzato, G. P., Biassoni, R., Moretta, L. and Moretta, A., A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human Natural Killer cells and induces both triggering of cell functions and proliferation. Eur. J. Immunol. 1996. 26: 1816-1824.
22. Moretta, A., Vitale, M., Sivori, S., Bottino, C., Morelli, L., Augugliaro, R., Barbaresi, M., Pende, D., Ciccone, E., Lopez-Botet, M. and Moretta, L., Human Natural Killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles. J. Exp. Med. 1994. 180: 545-555.
23. Phillips, J. H., Chang, C., Mattson, J., Gumperz, J. E., Parham, P. and Lanier, L. L., CD94 and a novel associated protein (94AP) form an NK cell receptor involved in the recognition of HLA-A, -B, -C allotypes. Immunity 1996. 5: 163-172.
24. Sivori, S., Vitale, M., Bottino, C., Marcenaro, E., Sanseverino, L., Parolini, S., Moretta, L. and Moretta, A., CD94 functions as a natural killer cell inhibitory receptor for different HLA-class-I alleles. Identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies. Eur. J. Immunol. 1996. 26: 2487-2492.
25. Pende, D., Sivori, S., Accame, L., Pareti, L., Falco, M., Geraghty, D., Le Bouteiller, F., Moretta, L. and Moretta, A., HLA-G recognition by human natural killer cells. Involvement of CD94 both as inhibitory and as activating receptor complex. Eur. J. Immunol. 1997. 27: 1875-1880.
26. Perez-Villar, J. J., Melero, I., Navarro, F., Carretero, M., Bellon, T., Llano, M., Colonna, M., Geraghty, D. E. and Lòpez-Botet, M., The CD94/NKG2A inhibitory receptor complex is involved in the natural killer cell-mediated recognition of cells expressing HLA-G1. J. Immunol. 1997. 158: 5736-5743.
27. Söderström, K., Corliss, B., Lanier, L. L. and Phillips, J. H., CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells. J. Immunol. 1997. 159: 1072-1075.
28. Peréz-Villar, J. J., Melero, I., Rodrìguez, A., Carretero, M., Aramburu, J., Sivori, S., Orengo, A. M., Moretta, A. and Lòpez-Botet, M., Functional ambivalence of the Kp43 (CD94) NK cell-associated surface antigen. J. Immunol. 1995. 154: 5779-5788.
29. Pérez-Villar, J. J., Carretero, M., Navarro, F., Melero, I., Rodrìguez, A., Bottino, C. Moretta, A. and Lopez-Botet, M., Biochemical and serological evidence for the existence of functionally distinct isoforms of the CD94 NK cell receptor. J. Immunol. 1996. 157: 5367-5374.
30. + T lymphocytes. Inhibition of IL-2 dependent proliferation by anti-Kp43 monoclonal antibody. J. Immunol. 1990. 44: 3238-3247.
31. Carretero, M., Cantoni, C., Bellón, T., Bottino, C., Biassoni, R., Rodríguez, A., Pérez-Villar, J. J., Moretta, L., Moretta, A. and López-Botet, M., The CD94 and NKG2-A C-type lectins covalently assamble to form a a NK cell inhibitory receptor for HLA class I molecules. Eur. J. Immunol. 1997. 27: 563-567.
32. Lazetic, S.,. Chang, C., Houchins, J. P., Lanier, L. L. and Phillips, J. H., Human Natural killer cell receptors involved in MHC class I recognition are disulphide-linked heterodimers of CD94 and NKG2 subunits. J. Immunol. 1996. 157: 4741-4745.
33. Brooks, A. G., Posch, P. E., Scorzelli, C. J., Borrego, F. and Coligan, J. E., NKG2A complexes with CD94 defines a novel inhibitory natural killer cell receptor. J. Exp. Med. 1997. 185: 795-800.
34. Chang, C., Rodríguez, A., Carretero, M., Lòpez-Botet, M., Phillips, J. H. and Lanier, L. L., Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily. Eur. J. Immunol. 1995. 25: 2433-2437.
35. Houchins, J. P., Yabe, T., McSherry, C. and Bach, F. H., DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J. Exp. Med. 1991. 173: 1017-1020.
36. Yabe, T., McSherry, C., Bach, F. H., Fisch, P., Schall, R. P., Sondel, P. M. and Houchins, J. P., A multigene family on human chromosome 12 encodes natural killer cell lectins. Immunogenetics. 1993. 37: 455-460.
37. Houchins, J. P., Lanier, L. L., Niemi, E. C., Phillips, J. H. and Ryan, J. C., Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C. J. Immunol. 1997. 158: 3603-3609.
38. Renard, V., Cambiaggi, A., Vély, F., Bléry, M., Olcese, L., Olivero, S., Bouchet, M. and Vivier, E., Transduction of cytotoxic signals in natural killer cells: a general model of fine tuning between activatory and inhibitory pathways in lymphocytes, Immunol. Rev. 1997. 155: 205-221.