HLA class I specific inhibitory receptors

Current Opinion in Immunology

Volumn 9, Issue 5, 1997, Pages 694-701

  Moretta, Alessandro ^a   Moretta, Lorenzo ^b  

^a UNIVERSITY OF BRESCIA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 1; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN TYROSINE PHOSPHATASE;

CROSS LINKING; DOWN REGULATION; MEMORY CELL; NATURAL KILLER CELL; REVIEW;

EID: 0030706172     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(97)80051-9     Document Type: Article

References (62)

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14. Biassoni R, Cantoni C, Falco M, Verdiani S, Bottino C, Vitale M, Conte R, Poggi A, Moretta A, Moretta L. The HLA-C-specific 'activatory' or 'inhibitory' Natural Killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. of outstanding interest J Exp Med. 183:1996;645-650 A follow up to the previous discovery [13] of the activating forms of HLA-C-specific natural killer cell receptors (NKRs). The molecular cloning of the genes encoding the activating receptors shows an amino acid sequence identity of the activating receptors with the inhibitory receptors in the extra-cellular domains, but there are important differences in the transmembrane and intracytoplasmic regions.
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18. Vitale M, Sivori S, Pende D, Augugliaro R, Di Donato C, Amoroso A, Malnati M, Bottino C, Moretta L, Moretta A. Physical and functional independency of p70 and p58 NK cell receptors for HLA-class I. Their role in the definition of different groups of alloreactive NK cell clones. of special interest Proc Natl Acad Sci USA. 93:1996;1453-1457 The HLA-Bw4 specific natural killer cell receptor (NKR) p70 corresponds to the previously described NKB1 molecule [15]. The authors of this paper show that when p70 is co-expressed with another inhibitory NKR, p58, both receptors function independently. Furthermore, expression of p70 either alone or in combination with other NKRs is shown to determine the ability of the NKR-bearing cell to lyse allogeneic cells. This study reaches similar conclusions as those in [17].
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26. Sivori S, Vitale M, Bottino C, Marcenaro E, Sanseverino L, Parolini S, Moretta L, Moretta A. CD94 functions as a natural killer cell inhibitory receptor for different HLA-class-I alleles. Identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies. of outstanding interest Eur J Immunol. 26:1996;2487-2492 The authors demonstrate that the CD94 natural killer cell receptor (NKR) has a broad specificity for different HLA class I alleles and they clearly distinguish the inhibitory form from the activating form by the aid of mAbs specific for a molecule associated with the inhibitory form.
27. Phillips JH, Chang C, Mattson J, Gumperz JE, Parham P, Lanier LL. CD94 and a novel associated protein (94AP) form of a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes. of outstanding interest Immunity. 5:1996;163-172 Using a slightly different approach to that of [26], the authors reach a similar conclusion, namely that the CD94 natural killer cell receptor (NKR) has a broad specificity for different HLA class I alleles. Again, the inhibitory form of CD94 is clearly distinguished from the activating form.
28. Carretero M, Cantoni C, Belln T, Bottino C, Biassoni R, Rodriguez A, Pérez-Villar JJ, Moretta L, Moretta A, López-Botet M. The CD94 and NKG2-A C-type lectins covalently assemble to form a NK cell inhibitory receptor for HLA class I molecules. of outstanding interest Eur J Immunol. 27:1997;563-567 Thanks to mAbs specific for the inhibitory form of the CD94 natural killer cell receptor (NKR) [26], this study shows that the 'inhibitory form' is actually composed of CD94 associated with NKG2A. Although the corresponding cDNA of NKG2A, a type II molecule, has been known for several years, its molecular product and function had remained elusive. See also [29].
29. Lazetic S, Chang C, Houchins JP, Lanier LL, Philips JH. Human natural killer cell receptors involved in MHC class I recognition are disulphide-linked heterodimers of CD94 and NKG2 subunits. of outstanding interest J Immunol. 157:1996;4741-4745 The authors reach the same conclusion as that of [28], that is, that CD94 and NKG2A assemble to form heterodimers that are an actual HLA class I specific inhibitory receptor.
30. + precursors undergoing maturation towards mature NK cells, the authors show that IL-15 is capable of inducing the expression of CD94-NKG2A in parallel with the acquisition of cytolytic function. This mechanism prevents the lysis of autologous cells.
31. Rénard V, Cambiaggi A, Vely F, Blery M, Olcese L, Olivero S, Bouchet M, Vivier E. Transduction of cytotoxic signals in Natural Killer cells: a general model of fine tuning between activatory and inhibitory pathways in lymphocytes. Immunol Rev. 155:1997;205-221.
32. + NK cell or T lymphocyte cell killing activity. The mechanism involves the recruitment of the Src homology 2 domain containing protein tyrosine phosphatase (SHP)-1 hemopoietic phosphatase to the NKR immunoreceptor tyrosine based inhibition motifs. See also [33-35].
33. + NK cell or T lymphocyte cell killing activity. The mechanism involves the recruitment of the Src homology 2 domain containing protein tyrosine phosphatase (SHP)-1 hemopoietic phosphatase to the NKR immunoreceptor tyrosine based inhibition motifs. See also [32,34,35].
34. + NK cell or T lymphocyte cell killing activity. The mechanism involves the recruitment of the Src homology 2 domain containing protein tyrosine phosphatase (SHP)-1 hemopoietic phosphatase to the NKR immunoreceptor tyrosine based inhibition motifs. See also [32,33,35].
35. + NK cell or T lymphocyte cell killing activity. The mechanism involves the recruitment of the Src homology 2 domain containing protein tyrosine phosphatase (SHP)-1 hemopoietic phosphatase to the NKR immunoreceptor tyrosine based inhibition motifs. See also [32-34].
36. Blery M, Delon J, Trautmann A, Cambiaggi A, Olcese L, Biassoni R, Moretta L, Chavrier P, Moretta A, Daron M, Vivier E. Reconstituted killer-cell inhibitory receptors for MHC class I molecules control mast cell activation induced via immunoreceptor tyrosine-based activation motifs. of special interest J Biol Chem. 272:1997;8989-8996 The authors show that inhibitory natural killer cell receptors (NKRs) need to be cross-linked with activating receptors involved in the activation of kinases. A likely explanation for this requirement is that Tyr phosphorylation of ITIMs in the cytoplasmic tail of NKRs is required for the recruitment of Src homology 2 domain containing protein tyrosine phosphatases.
37. Binstadt BA, Brumbaugh KM, Leibson PJ. Signal transduction by human NK cell MHC-recognizing receptors. of special interest Immunol Rev. 155:1997;197-203 An interesting review that also contains new data and a model for natural killer cell receptor (NKR) signalling.
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42. Perez-Villar JJ, Melero I, Navarro F, Carretero M, Bellon T, Llano M, Colonna M, Geraghty DE, López-Botet M. The CD94/NKG2A inhibitory receptor complex is involved in the Natural Killer cell-mediated recognition of cells expressing HLA-G1. of special interest J Immunol. 1997; According to these authors, the recognition of HLA-G molecules is mediated by the CD94 - NKG2A complex and not by other known natural killer cell receptors (NKRs). See also [43-45].
43. Pende D, Sivori S, Accame L, Pareti L, Falco M, Geraghty D, Le Bouteiller P, Moretta L, Moretta A. HLA-G recognition by human natural killer cells. Involvement of CD94 both as inhibitory and as activating receptor complex. of special interest Eur J Immunol. 27:1997;1875-1880 As in [42], recognition of HLA-G molecules is shown to be mediated by the CD94-NKG2A coomplex. In addition, the authors show that the activating form of the CD94 receptor can recognize HLA-G. See also [44,45].
44. Pazmany L, Mandelboim O, Valés-Gómez M, Davis DM, Reyburn HT, Strominger JL. Protection from Natural killer cells-mediated lysis by HLA-G expression on target cells. of special interest Science. 274:1996;792-795 The authors identify the p58 molecules p58.1 and p58.2 as the putative HLA-G-specific receptors. See also [42,43,45].
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49. Beck S, Barrell BG. Human cytomegalovirus encodes a glycoprotein homologous to MHC class I-antigens. Nature. 331:1988;269-272.
50. Reyburn HT, Mandelboim O, Valès-Gomez M, Davis DM, Pazmani L, Strominger JL. The class I MHC homologue of human cytomegalovirus inhibits attack by natural killer cells. of outstanding interest Nature. 386:1997;514-516 The authors show that an MHC class I homologous, HCMV-encoded, protein protects HCMV-infected cells from NK cell mediated lysis.
51. Farrell HE, Hally H, Lynch DM, Fleming P, Shellam GR, Scalzo AA, Davis-Poynter NJ. Inhibition of natural killer cells by a cytomegalovirus MHC class I homologoue in vivo. of outstanding interest Nature. 386:1997;510-514 The authors show that an MHC class I homologous, HCMV-encoded, protein protects HCMV-infected cells from NK cell mediated lysis.
52. Ferrini S, Cambiaggi A, Meazza R, Sforzini S, Marciano S, Mingari MC, Moretta L. T cell clones expressing the NK-related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function. Eur J Immunol. 24:1994;2294-2298.
53. Mingari MC, Vitale C, Cambiaggi A, Schiavetti F, Melioli G, Ferrini S, Poggi A. Cytolytic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production. Int Immunol. 4:1995;697-703.
54. Phillips JH, Gumperz JE, Parham P, Lanier LL. Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptor on T lymphocytes. Science. 128:1995;403-405.
55. + cells [53].
56. + T lymphocytes are present in tonsils, lymph nodes whereas they are absent in thymus and umbilical cord blood. In addition, polymerase chain reaction amplified T lymphocyte NKR cDNAs are shown to be identical to those of NK cells.
57. + T cells isolated from healthy donors display a memory phenotype and are oligoclonal or monoclonal in nature.
58. Ikeda H, Lethé B, Lehmann F, Van Baren N, Baurain JF, De Smet C, Chambost H, Vitale M, Moretta A, Boon T, Coulie PG. Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. of outstanding interest Immunity. 6:1997;199-208 This study demonstrates that tumor antigen specific CTLs may express inhibitory natural killer cell receptors (NKRs) and that this may lead to impaired antitumor responses.
59. + T cells from HIV patients. In addition, the authors show that these NKRs are expressed on HIV-specific CTLs and prevent lysis of autologous HIV antigen expressing target cells.
60. Mandelboim O, Davis DM, Reyburn HT, Vales-Gomez M, Sheu EG, Pazmany L, Strominger JL. Enhancement of class II-restricted T cell responses by costimulatory NK receptors for class I MHC proteins. of special interest Science. 274:1996;2097-2100 The activating p50 molecules, when expressed in T lymphocytes, may allow responses to lower doses of superantigens, provided that target cells express the appropriate HLA-C ligand.
61. Sivori S, Vitale M, Morelli L, Sanaseverino L, Augugliaro R, Bottino C, Moretta L, Moretta A. p46, a novel Natural Killer cell-specific surface molecule which mediates cell activation. of outstanding interest J Exp Med. 1997; This study describes p46, a novel surface molecule which is strictly NK-specific. More importantly, p46 induces potent NK cell triggering and may be involved in the process of HLA class I independent NK cell triggering.
62. Cambiaggi A, Verthuy C, Naquet P, Romagné F, Ferrier P, Biassoni R, Moretta A, Moretta L, Vivier E. NK-cell acceptance of H-2 mismatch bone-marrow grafts in transgenic mice expressing HLA-Cw3 specific killer-cell inhibitory receptor (CD158b). of outstanding interest Proc Natl Acad Sci USA. 94:1997;8088-8092 This study provides the first evidence for an in vivo role for human natural killer cell receptors (NKRs) in the immune response against mistmatched bone marrow grafts in a transgenic mice model.