-
1
-
-
0028934154
-
Natural killer cell receptors specific for major histocompatibility complex class I molecules
-
Yokoyama, W. M., Natural killer cell receptors specific for major histocompatibility complex class I molecules. Proc. Natl. Acad. Sci. USA 1995. 92: 3081-3085.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 3081-3085
-
-
Yokoyama, W.M.1
-
2
-
-
0029003984
-
Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells
-
Colonna, M. and Samaridis, J., Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 1995. 268: 405-408.
-
(1995)
Science
, vol.268
, pp. 405-408
-
-
Colonna, M.1
Samaridis, J.2
-
3
-
-
0029015726
-
Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains
-
Wagtmann, N., Biassoni, R., Cantoni, C., Verdiani, S., Malnati, M. S., Vitale, M., Cottino, C., Moretta, L., Moretta, A. and Long, E. O., Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity 1995. 2: 439-449.
-
(1995)
Immunity
, vol.2
, pp. 439-449
-
-
Wagtmann, N.1
Biassoni, R.2
Cantoni, C.3
Verdiani, S.4
Malnati, M.S.5
Vitale, M.6
Cottino, C.7
Moretta, L.8
Moretta, A.9
Long, E.O.10
-
4
-
-
0030042385
-
Inhibitory MHC class I receptors on NK cells and T cells
-
Lanier, L. L. and Phillips, J. H., Inhibitory MHC class I receptors on NK cells and T cells. Immunol. Today 1996. 17: 86-91.
-
(1996)
Immunol. Today
, vol.17
, pp. 86-91
-
-
Lanier, L.L.1
Phillips, J.H.2
-
5
-
-
0029874672
-
Receptors for HLA class I molecules in human natural killer cells
-
Moretta, A., Bottino, C., Vitale, M., Pende, D., Biassoni, R., Mingari, M. C. and Moretta, L., Receptors for HLA class I molecules in human natural killer cells. Annu. Rev. Immunol. 1996. 14: 619-648.
-
(1996)
Annu. Rev. Immunol.
, vol.14
, pp. 619-648
-
-
Moretta, A.1
Bottino, C.2
Vitale, M.3
Pende, D.4
Biassoni, R.5
Mingari, M.C.6
Moretta, L.7
-
6
-
-
0031172446
-
Immunoreceptor tyrosine-based inhibition motifs
-
Vivier, E. and Daëron, M., Immunoreceptor tyrosine-based inhibition motifs. Immunol. Today 1997. 18: 286-291.
-
(1997)
Immunol. Today
, vol.18
, pp. 286-291
-
-
Vivier, E.1
Daëron, M.2
-
7
-
-
0030024788
-
Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor
-
Burshtyn, D. N., Scharenberg, A. M., Wagtmann, N., Rajagopalan, S., Berrada, K., Yi, T., Kinet, J-P. and Long, E. O., Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor. Immunity 1996. 4: 77-85.
-
(1996)
Immunity
, vol.4
, pp. 77-85
-
-
Burshtyn, D.N.1
Scharenberg, A.M.2
Wagtmann, N.3
Rajagopalan, S.4
Berrada, K.5
Yi, T.6
Kinet, J.-P.7
Long, E.O.8
-
8
-
-
0030036615
-
Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C
-
Campbell, K. S., Dessing, M., López-Botet, M., Cella, M. and Colonna, M., Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C. J. Exp. Med. 1996. 184: 1373-1389.
-
(1996)
J. Exp. Med.
, vol.184
, pp. 1373-1389
-
-
Campbell, K.S.1
Dessing, M.2
López-Botet, M.3
Cella, M.4
Colonna, M.5
-
9
-
-
0030037132
-
Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C
-
Fry, A. M., Lanier, L. L. and Weiss, A., Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C. J. Exp. Med. 1996. 184: 295-300.
-
(1996)
J. Exp. Med.
, vol.184
, pp. 295-300
-
-
Fry, A.M.1
Lanier, L.L.2
Weiss, A.3
-
10
-
-
0008900035
-
Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases
-
Olcese, L., Lang, P., Vély, F., Cambiaggi, A., Marguet, D., Bléry, M., Hippen, K. L., Biassoni, R., Moretta, A., Moretta, L., Cambier, J. C. and Vivier, E., Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases. J. Immunol. 1996. 156: 4531-4534.
-
(1996)
J. Immunol.
, vol.156
, pp. 4531-4534
-
-
Olcese, L.1
Lang, P.2
Vély, F.3
Cambiaggi, A.4
Marguet, D.5
Bléry, M.6
Hippen, K.L.7
Biassoni, R.8
Moretta, A.9
Moretta, L.10
Cambier, J.C.11
Vivier, E.12
-
11
-
-
0031020638
-
Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase
-
Nakamura, M. C., Niemi, E. C., Fisher, M. J., Shultz, L. D., Seaman, W. E. and Ryan, J. C., Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase. J. Exp. Med. 1997. 185: 673-684.
-
(1997)
J. Exp. Med.
, vol.185
, pp. 673-684
-
-
Nakamura, M.C.1
Niemi, E.C.2
Fisher, M.J.3
Shultz, L.D.4
Seaman, W.E.5
Ryan, J.C.6
-
12
-
-
0030497720
-
Sequential involvement of lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation
-
Binstadt, B. A., Brumbaugh, K. M., Dick, C. J., Scharenberg, A. M., Williams, B. L., Colonna, M., Lanier, L. L., Kinet, J-P., Abraham, R. T. and Leibson, P. J., Sequential involvement of lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. Immunity 1996. 5: 629-638.
-
(1996)
Immunity
, vol.5
, pp. 629-638
-
-
Binstadt, B.A.1
Brumbaugh, K.M.2
Dick, C.J.3
Scharenberg, A.M.4
Williams, B.L.5
Colonna, M.6
Lanier, L.L.7
Kinet, J.-P.8
Abraham, R.T.9
Leibson, P.J.10
-
13
-
-
0028142371
-
lck kinase
-
lck kinase. Eur. J. Immunol. 1994. 24: 2527-2534.
-
(1994)
Eur. J. Immunol.
, vol.24
, pp. 2527-2534
-
-
Bottino, C.1
Vitale, M.2
Olcese, L.3
Sivori, S.4
Morelli, L.5
Augugliaro, R.6
Ciccone, E.7
Moretta, L.8
Moretta, A.9
-
14
-
-
0030042385
-
Inhibitory MHC class I receptors on NK cells and T cells
-
Lanier, L. L. and Phillips, J. H., Inhibitory MHC class I receptors on NK cells and T cells. Immunol. Today 1996. 17: 86-91.
-
(1996)
Immunol. Today
, vol.17
, pp. 86-91
-
-
Lanier, L.L.1
Phillips, J.H.2
-
15
-
-
0030470555
-
Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits
-
Lazetic, S., Chang, C., Houchins, P. J., Lanier, L. L. and Phillips, J. H., Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits. J. Immunol. 1996. 157: 4741-4745.
-
(1996)
J. Immunol.
, vol.157
, pp. 4741-4745
-
-
Lazetic, S.1
Chang, C.2
Houchins, P.J.3
Lanier, L.L.4
Phillips, J.H.5
-
16
-
-
0031053033
-
The CD94 and NKG2-a C-type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLa class I molecules
-
Carretero, M., Cantoni, C., Bellón, T., Bottino, C., Biassoni, R., Rodríguez, A., Pérez-Villar, J. J., Moretta, L., Moretta, A. and López-Botet, M., The CD94 and NKG2-A C-type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules. Eur. J. Immunol. 1997. 27: 563-567.
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 563-567
-
-
Carretero, M.1
Cantoni, C.2
Bellón, T.3
Bottino, C.4
Biassoni, R.5
Rodríguez, A.6
Pérez-Villar, J.J.7
Moretta, L.8
Moretta, A.9
López-Botet, M.10
-
17
-
-
0031018766
-
NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor
-
Brooks, A. G., Posch, P. E., Scorzelli, C. J., Borrego, F. and Coligan, J. E., NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor. J. Exp. Med. 1997. 185: 795-800.
-
(1997)
J. Exp. Med.
, vol.185
, pp. 795-800
-
-
Brooks, A.G.1
Posch, P.E.2
Scorzelli, C.J.3
Borrego, F.4
Coligan, J.E.5
-
18
-
-
0029063555
-
Functional ambivalence of the Kp43 (CD94) NK cell-associated surface antigen
-
Pérez-Villar, J. J., Melero, I., Rodríguez, A., Carretero, M., Aramburu, J., Sivori, S., Orengo, A. M., Moretta, A. and López-Botet, M., Functional ambivalence of the Kp43 (CD94) NK cell-associated surface antigen. J. Immunol. 1995. 154: 5779-5788.
-
(1995)
J. Immunol.
, vol.154
, pp. 5779-5788
-
-
Pérez-Villar, J.J.1
Melero, I.2
Rodríguez, A.3
Carretero, M.4
Aramburu, J.5
Sivori, S.6
Orengo, A.M.7
Moretta, A.8
López-Botet, M.9
-
19
-
-
0030589299
-
Biochemical and serologic evidence for the existence of functionally distinct forms of the CD94 NK cell receptor
-
Pérez-Villar, J. J., Carretero, M., Navarro, F., Melero, I., Rodríguez, A., Bottino, C., Moretta, A. and López-Botet, M., Biochemical and serologic evidence for the existence of functionally distinct forms of the CD94 NK cell receptor. J. Immunol. 1996. 157: 5367-5374.
-
(1996)
J. Immunol.
, vol.157
, pp. 5367-5374
-
-
Pérez-Villar, J.J.1
Carretero, M.2
Navarro, F.3
Melero, I.4
Rodríguez, A.5
Bottino, C.6
Moretta, A.7
López-Botet, M.8
-
20
-
-
0029801052
-
CD94 functions as a natural killer cell inhibitory receptor for different HLa class I alleles: Identification of the inhibitory form of CD94 by the use of a novel monoclonal antibody
-
Sivori, S., Vitale, M., Bottino, C., Marcenato, E., Sanseverino, L., Parolini, S., Moretta, L. and Moretta, A., CD94 functions as a natural killer cell inhibitory receptor for different HLA class I alleles: Identification of the inhibitory form of CD94 by the use of a novel monoclonal antibody. Eur. J. Immunol. 1996. 26: 2487-2492.
-
(1996)
Eur. J. Immunol.
, vol.26
, pp. 2487-2492
-
-
Sivori, S.1
Vitale, M.2
Bottino, C.3
Marcenato, E.4
Sanseverino, L.5
Parolini, S.6
Moretta, L.7
Moretta, A.8
-
21
-
-
0028360117
-
Human natural killer cell receptors for HLA-class I molecules. Evidence that the kp43 (CD94) molecule functions as receptor for HLA-B alleles
-
Moretta, A., Vitale, M., Sivori, S., Bottino, C., Morelli, L., Augugliaro, R., Barbaresi, M., Pende, D., Ciccone, E., López-Botet, M. and Moretta, L., Human natural killer cell receptors for HLA-class I molecules. Evidence that the kp43 (CD94) molecule functions as receptor for HLA-B alleles. J. Exp. Med. 1994. 180: 545-555.
-
(1994)
J. Exp. Med.
, vol.180
, pp. 545-555
-
-
Moretta, A.1
Vitale, M.2
Sivori, S.3
Bottino, C.4
Morelli, L.5
Augugliaro, R.6
Barbaresi, M.7
Pende, D.8
Ciccone, E.9
López-Botet, M.10
Moretta, L.11
-
22
-
-
0030217971
-
CD94 and a novel associated protein (94AP) form an NK cell receptor involved in the recognition of HLA-a and HLA-C allotypes
-
Phillips, J. H., Chang, C., Mattson, J., Gumperz, J. E., Parham, P. and Lanier, L. L., CD94 and a novel associated protein (94AP) form an NK cell receptor involved in the recognition of HLA-A and HLA-C allotypes. Immunity 1996. 5: 163-172.
-
(1996)
Immunity
, vol.5
, pp. 163-172
-
-
Phillips, J.H.1
Chang, C.2
Mattson, J.3
Gumperz, J.E.4
Parham, P.5
Lanier, L.L.6
-
23
-
-
0031570502
-
The CD94/NKG2-A inhibitory receptor complex is involved in NIK cell-mediated recognition of cells expressing HLA-G1
-
Pérez-Villar, J. J., Melero, I., Navarro, F., Carretero, M., Bellón, T., Llano, M., Colonna, M., Geraghty, D. E. and López-Botet, M., The CD94/NKG2-A inhibitory receptor complex is involved in NIK cell-mediated recognition of cells expressing HLA-G1. J. Immunol. 1997. 158: 5736-5743.
-
(1997)
J. Immunol.
, vol.158
, pp. 5736-5743
-
-
Pérez-Villar, J.J.1
Melero, I.2
Navarro, F.3
Carretero, M.4
Bellón, T.5
Llano, M.6
Colonna, M.7
Geraghty, D.E.8
López-Botet, M.9
-
24
-
-
0031202039
-
CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells
-
Soderström, K., Corliss, B., Lanier, L. L. and Phillips, J. H., CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells. J. Immunol. 1997. 159: 1072-1075.
-
(1997)
J. Immunol.
, vol.159
, pp. 1072-1075
-
-
Soderström, K.1
Corliss, B.2
Lanier, L.L.3
Phillips, J.H.4
-
25
-
-
0030786595
-
HLA-G recognition by human natural killer cells. Involvement of CD94 both as inhibitory and activating receptor complex
-
Pende, D., Sivori, S., Accame, L., Pareti, L., Falco, M., Geraghty, D. E., Le Bouteiller, P., Moretta, L. and Moretta, A., HLA-G recognition by human natural killer cells. Involvement of CD94 both as inhibitory and activating receptor complex. Eur. J. Immunol. 1997. 27: 1875-1880.
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 1875-1880
-
-
Pende, D.1
Sivori, S.2
Accame, L.3
Pareti, L.4
Falco, M.5
Geraghty, D.E.6
Le Bouteiller, P.7
Moretta, L.8
Moretta, A.9
-
26
-
-
0032574781
-
HLA-E is a major ligand for the NK inhibitory receptor CD94/ NKG2A
-
n press
-
Lee, N., Llano, M., Carretero, M., Ishitani, A., Navarro, F., López-Botet, M. and Geraghty, D. E., HLA-E is a major ligand for the NK inhibitory receptor CD94/ NKG2A. Proc. Natl. Acad. Sci. USA 1998, n press.
-
(1998)
Proc. Natl. Acad. Sci. USA
-
-
Lee, N.1
Llano, M.2
Carretero, M.3
Ishitani, A.4
Navarro, F.5
López-Botet, M.6
Geraghty, D.E.7
-
27
-
-
15444341090
-
HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences
-
In press
-
Lee, N., Goodlett, D. R., Ishitani, A., Marquardt, H. and Geraghty, D. E., HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences. J. Immunol. 1997, In press.
-
(1997)
J. Immunol.
-
-
Lee, N.1
Goodlett, D.R.2
Ishitani, A.3
Marquardt, H.4
Geraghty, D.E.5
-
28
-
-
0030988540
-
The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9
-
Braud, V., Jones, E. Y. and McMichael, A., The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9. Eur. J. Immunol. 1997. 27: 1164-1169.
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 1164-1169
-
-
Braud, V.1
Jones, E.Y.2
McMichael, A.3
-
29
-
-
0031569525
-
Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C
-
Houchins, J. P., Lanier, L. L., Niemi, E. C., Phillips, J. H. and Ryan, J. C., Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C. J. Immunol. 1997. 158: 3603-3609.
-
(1997)
J. Immunol.
, vol.158
, pp. 3603-3609
-
-
Houchins, J.P.1
Lanier, L.L.2
Niemi, E.C.3
Phillips, J.H.4
Ryan, J.C.5
-
30
-
-
0030266705
-
Clonotypic differences in signalling from CD94 (kp43) on NK cells lead to divergent cellular responses
-
Brumbaugh, K. M., Pérez-Villar, J. J., Dick, C. J., Schoon, R. A., López-Botet, M. and Leibson, P. J., Clonotypic differences in signalling from CD94 (kp43) on NK cells lead to divergent cellular responses. J. Immunol. 1996. 157: 2804-2812.
-
(1996)
J. Immunol.
, vol.157
, pp. 2804-2812
-
-
Brumbaugh, K.M.1
Pérez-Villar, J.J.2
Dick, C.J.3
Schoon, R.A.4
López-Botet, M.5
Leibson, P.J.6
-
31
-
-
0030848994
-
Signal transduction during Natural Killer Cell activation: Inside the mind of a killer
-
Leibson, P. J., Signal transduction during Natural Killer Cell activation: inside the mind of a killer. Immunity 1997. 6: 655-661.
-
(1997)
Immunity
, vol.6
, pp. 655-661
-
-
Leibson, P.J.1
-
32
-
-
0343120789
-
Reconstituted killer cell inhibitory receptors for major histocompatibility complex class I molecules control mast cell activation induced via immunoreceptor tyrosine-based activation motifs
-
Bléry, M., Delon, J., Trautmann, A., Cambiaggi, A., Olcese, L., Biassoni, R., Moretta, L., Chavrier, P., Moretta, A., Daëron, M. and Vivier, E., Reconstituted killer cell inhibitory receptors for major histocompatibility complex class I molecules control mast cell activation induced via immunoreceptor tyrosine-based activation motifs. J. Biol. Chem. 1997. 272: 8989-8996.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 8989-8996
-
-
Bléry, M.1
Delon, J.2
Trautmann, A.3
Cambiaggi, A.4
Olcese, L.5
Biassoni, R.6
Moretta, L.7
Chavrier, P.8
Moretta, A.9
Daëron, M.10
Vivier, E.11
-
33
-
-
0031038920
-
Structure and function of the CD94 C-type lectin receptor complex involved in recognition of HLA class I molecules
-
López-Botet, M., Pérez-Villar, J. J., Carretero, M., Rodríguez, A., Melero, I., Bellón, T., Llano, M. and Navarro, F., Structure and function of the CD94 C-type lectin receptor complex involved in recognition of HLA class I molecules. Immunol. Rev. 1997. 155: 165-174.
-
(1997)
Immunol. Rev.
, vol.155
, pp. 165-174
-
-
López-Botet, M.1
Pérez-Villar, J.J.2
Carretero, M.3
Rodríguez, A.4
Melero, I.5
Bellón, T.6
Llano, M.7
Navarro, F.8
-
34
-
-
0027293914
-
Specificity of HLA class I antigen recognition by human NK clones: Evidence for clonal heterogeneity, protection by self and non-self alleles and influence of the target cell type
-
Litwin, V., Gumperz, J., Parham, P., Phillips, J. H. and Lanier, L. L., Specificity of HLA class I antigen recognition by human NK clones: evidence for clonal heterogeneity, protection by self and non-self alleles and influence of the target cell type. J. Exp. Med. 1993. 178: 1321-1336.
-
(1993)
J. Exp. Med.
, vol.178
, pp. 1321-1336
-
-
Litwin, V.1
Gumperz, J.2
Parham, P.3
Phillips, J.H.4
Lanier, L.L.5
-
35
-
-
0025349444
-
+ T lymphocytes: Inhibition of IL-2 dependent proliferation by anti-Kp43 monoclonal antibody
-
+ T lymphocytes: inhibition of IL-2 dependent proliferation by anti-Kp43 monoclonal antibody. J. Immunol. 1990. 144: 3238-3247.
-
(1990)
J. Immunol.
, vol.144
, pp. 3238-3247
-
-
Aramburu, J.1
Balboa, M.A.2
Ramírez, A.3
Silva, A.4
Acevedo, A.5
Sánchez-Madrid, F.6
De Landázuri, M.O.7
López-Botet, M.8
-
36
-
-
0028970731
-
Crosslinking of α4β1 and α5β1 fibronectin receptors enhances NK cytotoxic activity
-
Palmieri, G., Serra, A., De Maria, R., Gismondi, A., Milella, M., Piccoli, M., Frati, L. and Santoni, A., Crosslinking of α4β1 and α5β1 fibronectin receptors enhances NK cytotoxic activity. J. Immunol. 1995. 155: 5314-5322.
-
(1995)
J. Immunol.
, vol.155
, pp. 5314-5322
-
-
Palmieri, G.1
Serra, A.2
De Maria, R.3
Gismondi, A.4
Milella, M.5
Piccoli, M.6
Frati, L.7
Santoni, A.8
-
37
-
-
0025951923
-
Phosphorylation and dephosphorylation of the high affinity receptor of IgE immediately after receptor engagement and disengagement
-
Paolini, R., Jouvin, M. H. and Kinet, J. P., Phosphorylation and dephosphorylation of the high affinity receptor of IgE immediately after receptor engagement and disengagement. Nature 1991. 353: 855-858.
-
(1991)
Nature
, vol.353
, pp. 855-858
-
-
Paolini, R.1
Jouvin, M.H.2
Kinet, J.P.3
-
38
-
-
0029151163
-
Molecular characterization of human CD94: A type II membrane glycoprotein related to the C-type lectin superfamily
-
Chang, C., Rodríguez, A., Carretero, M., López-Botet, M., Phillips, J. H. and Lanier, L. L., Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily. Eur. J. Immunol. 1995. 25: 2433-2437.
-
(1995)
Eur. J. Immunol.
, vol.25
, pp. 2433-2437
-
-
Chang, C.1
Rodríguez, A.2
Carretero, M.3
López-Botet, M.4
Phillips, J.H.5
Lanier, L.L.6
|