Mutated human β3-adrenergic receptor (Trp64Arg) lowers the response to β3-adrenergic agonists in transfected 3T3-L1 preadipocytes

Hormone and Metabolic Research

Volumn 32, Issue 3, 2000, Pages 91-96

  Kimura, K ^a   Sasaki, N ^a   Asano, A ^a   Mizukami, J ^b   Kayahashi, S ^b   Kawada, T ^b   Fushiki, T ^b   Morimatsu, M ^c   Yoshida, T ^d   Saito, M ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c IWATE UNIVERSITY   (Japan)

^d KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

3T3 L1; cAMP; GTP; Guanosine Triphosphate; L 755,507; Obesity; 3 adrenergic Receptors

Indexed keywords

4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 4 [2 [(2 HYDROXY 3 PHENOXYPROPYL)AMINO]ETHOXY] N (2 METHOXYETHYL)PHENOXYACETAMIDE; 5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; ADENYLATE CYCLASE; ADRENALIN; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; COMPLEMENTARY DNA; CYCLIC AMP; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; HEXYLUREA; ISOPRENALINE; NORADRENALIN; UNCLASSIFIED DRUG; 1,3 DIOXOLANE DERIVATIVE; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; L 755507; PHENOXYACETIC ACID DERIVATIVE; PHENOXYPROPANOLAMINE DERIVATIVE; PROPANOLAMINE DERIVATIVE; RECOMBINANT PROTEIN; SULFONAMIDE;

ADRENERGIC SYSTEM; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; GENE MUTATION; MOLECULAR CLONING; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROADIPOCYTE; ADIPOCYTE; AMINO ACID SUBSTITUTION; ANIMAL; CYTOLOGY; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HUMAN; KINETICS; METABOLISM; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS;

ANIMALIA;

3T3 CELLS; ADENYLATE CYCLASE; ADIPOCYTES; ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; AMINO ACID SUBSTITUTION; ANIMALS; CYCLIC AMP; DIOXOLES; EPINEPHRINE; HUMANS; ISOPROTERENOL; KINETICS; MICE; MUTAGENESIS, SITE-DIRECTED; NOREPINEPHRINE; PHENOXYACETATES; PHENOXYPROPANOLAMINES; PROPANOLAMINES; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, ADRENERGIC, BETA-3; RECOMBINANT PROTEINS; SULFONAMIDES; TRANSFECTION;

EID: 0033625093     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-978597     Document Type: Article

References (37)

1. 1 Giacobino J-P. Beta 3-adrenoceptor: an update. Eur J Endocrinol 1995; 132: 377-385
2. 2 Lowell BB, Flier JS. Brown adipose tissue, β3-adrenergic receptors, and obesity. Ann Rev Med 1997; 48: 307-316
3. 3 Emorine LJ, Marullo S, Briend-Sutren MM, Patey G, Tate K, Delavier-Klutchko C, Strosberg AD. Molecular characterization of the human β3-adrenergic receptor. Science 1989; 245: 1118-1121
4. 4 Granneman JG, Lahners KM, Rao DD. Rodent and human β3-adrenergic receptor genes contain an intron within the protein-coding block. Mol Pharmacol 1992; 42: 964-970
5. 3 Lelias JM, Kaghad M, Rodriguez M, Chalon P, Bonnin J, Dupre I, Delpech B, Bensaid M, LeFur G, Ferrara P, Caput D. Molecular cloning of a human β-adrenergic receptor cDNA. FEBS Lett 1993; 324: 127-130
6. 6 Pietri-Rouxel F, Lenzen G, Kapoor A, Drumare MF, Archimbault P, Strosberg AD, Manning BS. Molecular cloning and pharmacological characterization of the bovine β3-adrenergic receptor. Eur J Biochem 1995; 230: 350-358
7. 7 Granneman JG, Lahners KM, Chaudhry A. Molecular cloning and expression of the rat β3-adrenergic receptor. Mol Pharmacol 1991; 40: 895-899
8. 8 Muzzin P, Revelli JP, Kuhne K, Gocayne JD, McCombie WR, Venter JC, Giacobino JP, Fraser CM. An adipose tissue-specific beta-adrenergic receptor. Molecular cloning and down-regulation in obesity. J Biol Chem 1991; 266: 24053-24058
9. 9 Atgie C, Tavernier G, D'Allaire F, Bengtsson T, Marti L, Carpene C, Lafontan M, Bukowiecki LJ, Langin D. β3-adrenoceptor in guinea pig brown and white adipocytes: low expression and lack of function. Am J Physiol 1996; 271: R1729-R1738
10. 10 Nahmias C, Blin N, Elalouf JM, Mattei MG, Strosberg AD, Emorine LJ. Molecular characterization of the mouse β3-adrenergic receptor: relationship with the atypical receptor of adipocytes. EMBO J 1991; 10: 3721-3727
11. 11 Susulic VS, Frederich RC, Lawitts J, Tozzo E, Kahn BB, Harper ME, Himms-Hagen J, Flier JS, Lowell BB. Targeted disruption of the β3-adrenergic receptor gene. J Biol Chem 1995; 270: 29483-29492
12. 12 Revelli JP, Preitner F, Samec S, Muniesa P, Kuehne F, Boss O, Vassalli JD, Dulloo A, Seydoux J, Giacobino JP, Huarte J, Ody C. Targeted gene disruption reveals a leptin-independent role for the mouse β3-adrenoceptor in the regulation of body composition. J Clin Invest 1997; 100: 1098-1106
13. 13 Nagase I, Yoshida T, Kumamoto K, Umekawa T, Sakane N, Nikami H, Kawada T, Saito M. Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic β3-adrenergic agonist. J Clin Invest 1996; 97: 2898-2904
14. 14 Umekawa T, Yoshida T, Sakane N, Saito M, Kumamoto K, Kondo M. Anti-obesity and anti-diabetic effects of CL316,243, a highly specific β3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats: induction of uncoupling protein and activation of glucose transporter 4 in white fat. Eur J Endocrinol 1997; 136: 429-437
15. 15 Clement K, Vaisse C, Manning BS, Basdevant A, Guy-Grand B, Ruiz J, Silver KD, Shuldiner AR, Froguel P, Strosberg AD. Genetic variation in the β3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. New Engl J Med 1995; 333: 352-354
16. 16 Widen E, Lehto M, Kanninen T, Walston J, Shuldiner AR, Groop LC. Association of a polymorphism in the β3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns. New Engl J Med 1995; 333: 348-351
17. 17 Walston J, Silver K, Bogardus C, Knowler WC, Celi FS, Austin S, Manning B, Strosberg AD, Stern MP, Raben N, Sorkin JD, Roth J, Shuldiner AR. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the β3-adrenergic-receptor gene. New-Engl J Med 1995; 333: 343-347
18. 18 Yoshida T, Sakane N, Umekawa T, Sakai M, Takahashi T, Kondo M. Mutation of β3-adrenergic-receptor gene and response to treatment of obestiy. Lancet 1995; 346: 1433-1434
19. 19 Strosberg AD. Association of β3-adrenoceptor polymorphism with obesity and diabetes: current status. Trends Pharmacol Sci 1997; 18: 449-454
20. 20 Candelore MR, Deng L, Tota LM, Kelly LJ, Cascieri MA, Strader CD. Pharmacological characterization of a recently described human β3-adrenergic receptor mutant. Endocrinology 1996; 137: 2638-2641
21. 21 Pietri-Rouxel F, St John Manning B, Gros J, Strosberg AD. The biochemical effect of the naturally occurring Trp64 → Arg mutation on human β3-adrenoceptor activity. Eur J Biochem 1997; 247: 1174-1179
22. 22 Fisher MH, Amend AM, Bach TJ, Barker JM, Brady EJ, Candelore MR, Carroll D, Cascieri MA, Chiu S-HL, Deng L, Forrest MJ, Hegarty-Friscino B, Guan X-M, Hom GJ, Hutchins JE, Kelly LJ, Mathvink RJ, Metzger JM, Miller RR, Ok HO, Parmee ER, Saperstein R, Strader CD, Stearns RA, Thompson GM, Tota L, Vicario PP, Weber AE, Woods JW, Wyvratt MJ, Zafian FT, MacIntyre DE. A selective human β3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys. J Clin Invest 1998; 101: 2387-2393
23. 23 Karasuyama H, Kudo A, Melchers F. The proteins encoded by the VpreB and 5 pre-B cell-specific genes can associate with each other and with heavy chain. J Exp Med 1990; 172: 969-972
24. o. J Biol Chem 1995; 270: 14672-14678
25. 125I-SCH 23982 binding, but increases the affinity of dopamine for D-1 dopamine receptors. J Neurochem 1994; 63: 2093-2098
26. 26 Lowry OH, Rosebrough NJ, Farr AL, Randall RJ, Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193: 265-275
27. 27 Esbenshade TA, Han C, Theroux TL, Granneman JG, Minneman KP. Coexisting beta 1-and atypical beta-adrenergic receptors cause redundant increases in cyclic AMP in human neuroblastoma cells. Mol Pharmacol 1992; 42: 753-759
28. 28 Blin N, Camoin L, Maigret B, Strosberg AD. Structural and conformational features determining selective signal transduction in the β3-adrenergic receptor. Mol Pharmacol 1993; 44: 1094-1104
29. 29 Granneman JG, Lahners KN, Zhai Y. Agonist interactions with chimeric and mutant beta1-and beta3-adrenergic receptors: Involvement of the seventh transmembrane region in conferring subtype specificity. Mol Pharmacol 1998; 53: 856-861
30. 30 Granneman JG, Lahners KN, Chaudhry A. Characterization of the human β3-adrenergic receptor gene. Mol Pharmacol 1993; 44: 264-270
31. 31 Cuan XM, Amend A, Strader CD. Determination of structural domains for G protein coupling and ligand binding in β3-adrenergic receptor. Mol Pharmacol 1995; 48: 492-498
32. 32 Hawes BE, Luttrell LM, Exum ST, Lefkowitz RJ. Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domain of the receptor, J Biol Chem 1994; 269: 15776 -15785
33. 33 Krief S, Lonnqvist F, Raimbault S, Baude B, Van Spronsen A, Arner P, Strosberg AD, Ricquier D, Emorine LJ. Tissue distribution of β3-adrenergic receptor mRNA in man. J Clin Invest 1993; 91: 344-349
34. 34 Deng C, Paoloni-Giacobino A, Kuehne F, Boss O, Revelli JP, Moinat M, Cawthorne MA, Muzzin P, Giacobino JP. Respective degree of expression of beta 1-, beta 2-and beta 3-adrenoceptors in human brown and white adipose tissues. Br J Pharmacol 1996; 118: 929-934
35. 35 Enocksson S, Shimizu M, Lonnqvist F, Nordenstrom J, Arner P. Demonstration of an in vivo functional β3-adrenoceptor in man. J Clin Invest 1995; 95: 2239-2245
36. 38 Lonnqvist F, Thome A, Nilsell K, Hoffstedt J, Arner P. A pathogenic role of visceral fat β3-adrenoceptors in obesity. J Clin Invest 1995; 95: 1109-1116
37. 37 Li LS, Lonnqvist F, Luthman H, Arner P. Phenotypic characterization of the Trp64Arg polymorphism in the β3-adrenergic receptor gene in normal weight and obese subjects. Diabetologia 1996; 39: 857-860