The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. II. An autosomal genome scan for diabetes-related quantitative-trait loci

American Journal of Human Genetics

Volumn 67, Issue 5, 2000, Pages 1186-1200

  Watanabe, Richard M ^a   Ghosh, Soumitra ^b,f   Langefeld, Carl D ^a,g   Valle, Timo T ^c   Hauser, Elizabeth R ^a,c,h   Magnuson, Victoria L ^b,c   Mohlke, Karen L ^b,c   Silander, Kaisa ^b,c   Ally, Delphine S ^b,c   Chines, Peter ^b,c   Blaschak Harvan, Jillian ^a,c   Douglas, Julie A ^a,c   Duren, William L ^a,c   Epstein, Michael P ^a,c   Fingerlin, Tasha E ^a,c   Kaleta, Hong Shi ^a,c   Lange, Ethan M ^a,c   Li, Chun ^a,c   McEachin, Richard C ^a,c   Stringham, Heather M ^a,c   Trager, Edward ^a,c   White, Peggy P ^a,c   Balow, James ^b,c   Birznieks, Gunther ^b,c   Chang, Jennie ^b,c   Eldridge, William ^b,c   Erdos, Michael R ^b,c   Karanjawala, Zarir E ^b,c   Knapp, Julie I ^b,c   Kudelko, Kristina ^b,c   Martin, Colin ^b,c   Morales Mena, Anabelle ^b,c   Musick, Anjene ^b,c   Musick, Tiffany ^b,c   Pfahl, Carrie ^b,c   Porter, Rachel ^b,c   Rayman, Joseph B ^b,c   Rha, David ^b,c   Segal, Leonid ^b,c   Shapiro, Shane ^b,c   Sharaf, Ravi ^b,c   Shurtleff, Ben ^b,c   So, Alistair ^b,c   Tannenbaum, Joyce ^b,c   Te, Catherine ^b,c   Tovar, Jason ^b,c   Unni, Arun ^b,c   Welch, Christian ^b,c   Whiten, Ray ^b,c   Witt, Alyson ^b,c   Ross, Edna H ^d   Demirchyan, Elza ^d   Hagopian, William A ^e   Buchanan, Thomas A ^d   Tuomilehto, Jaakko ^c   Bergman, Richard N ^d   Collins, Francis S ^b   Boehnke, Michael ^a   more..

^a UNIVERSITY OF MICHIGAN   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c KTL National Public Health Institute   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e UNIVERSITY OF WASHINGTON   (United States)

^f CHILDREN S HOSPITAL OF WISCONSIN   (United States)

^g WAKE FOREST SCHOOL OF MEDICINE   (United States)

^h DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CHROMOSOME 10; CHROMOSOME 13; CHROMOSOME 17; CHROMOSOME 3; CONTROLLED STUDY; FEMALE; FINLAND; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SIBLING;

EID: 0033758721     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9297(07)62949-8     Document Type: Article

References (54)

1. Robust variance-components approach for assessing genetic linkage in pedigrees
2. PPARgamma, the ultimate thrifty gene
3. Insulin-like growth factors and diabetes
4. Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-γ2 gene with obesity in two Caucasian populations
5. Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q
6. Toward physiological understanding of glucose tolerance: Minimal model approach
7. Quantitative estimation of insulin sensitivity
8. Physiologic evaluation of factors controlling glucose tolerance in man: Measurement of insulin sensitivity and β-cell glucose sensitivity from the response to intravenous glucose
9. Multipoint oligogenic linkage analysis of quantitative traits
10. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2
11. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
12. The triumvirate: β-Cell, muscle, liver: A collusion responsible for NIDDM
13. Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease
14. Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans
15. Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7
16. Genomewide search for type 2 diabetes susceptibility genes in four American populations
17. A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians
18. Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus
19. Genetic analysis of NIDDM: The study of quantitative traits
20. Type 2 diabetes: Evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs
21. The Finland-United States Investigation of Non-Insulin-Dependent Diabetes Mellitus Genetics (FUSION) Study. I. An autosomal genome scan for genes that predispose to type 2 diabetes
22. Association between polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus
23. A genomewide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2
24. An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians
25. Noninsulin-dependent diabetes mellitus in black and white Americans
26. Genetic linkage analysis of complex genetic traits by using affected sibling pairs
27. Mutation in hepatocyte nuclear factor-1β gene (TCF2) associated with MODY
28. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
29. Sib-pair linkage analysis for susceptibility genes for microvascular complications among Pima Indians with type 2 diabetes
30. Quantification of the relationship between insulin sensitivity and β-cell function in human subjects: Evidence for a hyperbolic function
31. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
32. Programs for pedigree analysis: MENDEL, FISHER, and dGENE
33. Insulin sensitivity and insulin secretion in monozygotic and dizygotic twins
34. Obesity and insulin resistance: Lessons learned from the Pima Indians
35. Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families
36. Association of the glycogen synthase locus on 19q13 with NIDDM in Pima Indians
37. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance
38. Risk factors for type 2 (non-insulin dependent) diabetes mellitus: Thirteen and one-half years of follow-up of the participants in a study of Swedish men born in 1913
39. An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians
40. Mapping genes in diabetes
41. Secretion of proinsulin C-peptide by pancreatic β cells and its circulation in blood
42. Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under nonstandard conditions
43. Glucose tolerance and insulin release, a mathematical approach. II. Approximation of the peripheral insulin resistance after oral glucose loading
44. Type 2 diabetes loci in the Old Order Amish
45. Reduced sample number for calculation of insulin sensitivity and glucose effectiveness from the minimal model: Suitability for use in population studies
46. Evidence for linkage of regions on chromosomes 6 and 11 to plasma glucose concentrations in Mexican Americans
47. Early-onset type-II diabetes mellitus (MODY4) linked to IPF1
48. Evidence for linkage between a region on chromosome 1p and the acute insulin response in Pima Indians
49. Mapping genes for NIDDM: Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study
50. A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q
51. Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus
52. Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus
53. Report of the expert committee on diabetes