Localization of tub and uncoupling proteins (Ucp) 2 and 3 to a region of rat chromosome 1 linked to glucose intolerance and adiposity in the Goto- Kakizaki (GK) type 2 diabetic rat

Mammalian Genome

Volumn 9, Issue 11, 1998, Pages 910-912

  Kaisaki, Pamela J ^a   Woon, Peng Y ^a   Wallis, Robert H ^a   Monaco, Anthony P ^a   Lathrop, Mark ^a   Gauguier, Dominique ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; UNCOUPLING PROTEIN;

ARTICLE; CHROMOSOME 1; CHROMOSOME 7; CONTROLLED STUDY; GENE ISOLATION; GENETIC SUSCEPTIBILITY; GLUCOSE INTOLERANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; QUANTITATIVE TRAIT; RAT;

ANIMALS; CARRIER PROTEINS; CHROMOSOMES; DIABETES MELLITUS, TYPE 2; GLUCOSE INTOLERANCE; IN SITU HYBRIDIZATION, FLUORESCENCE; ION CHANNELS; LINKAGE (GENETICS); MEMBRANE TRANSPORT PROTEINS; MICROSATELLITE REPEATS; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; OBESITY; PROTEINS; RATS;

EID: 0031763146     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003359900895     Document Type: Article

References (24)

1. 2 crosses. Genome Res 7, 434-440
2. Boss O, Samec S, Paolini-Giacobino A, Rossier C, Dulloo A et al. (1997) Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett 408, 29-42
3. Bouchard C, Pérusse L, Chagnon YC, Warden C, Ricquier D (1997) Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans. Hum Mol Genet 6, 1887-1889
4. Brilliant MH, Williams RW, Holdener BC, Angel JM, Stern M et al. (1997) Mouse chromosome 7. Mamm Genome 7(Suppl). S121-S142
5. Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ (1996) Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nat Genet 12, 44-51
6. Chung WK, Goldberg-Berman J, Power-Kehoe L, Leibel RL (1996) Molecular mapping of the Tubby (tub) mutation on mouse chromosome 7. Genomics 32, 210-217
7. fa associated with variability in insulin production and susceptibility to NIDDM. Genomics 41, 332-344
8. Fleury C, Neverova M, Collins S, Raimbault S, Champigny O et al. (1997) Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet 15, 269-272
9. Galli J, Li L-S, Glaser A, Östenson C-G, Jiao H et al. (1996) Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet 12, 31-37
10. Gauguier D, Froguel P, Parent V, Bernard C, Bihoreau, M-T et al. (1996) Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Nat Genet 12, 38-43
11. Jacob HJ, Krieger JE, Dzau VJ, Lander ES (1996) Genetic dissection of hypertension in experimental animal models. In Molecular Genetics and Gene Therapy of Cardiovascular Diseases, SC Mockrin, ed. (New York, N.Y.: Marcel Dekker, Inc.), pp 293-319
12. Kleyn PW, Fan W, Kovats SG, Lee JJ, Pulido JC et al. (1996) Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Cell 85, 281-290
13. Matsuda J, Hosoda K, Itoh H, Son C, Doi K et al. (1997) Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: their gene expression in rats fed high-fat diet. FEBS Lett 418, 200-204
14. Millwood IY, Bihoreau MT, Gauguier D, Hyne G, Levy ER et al. (1997) A gene-based genetic linkage and comparative map of the rat X chromosome. Genomics 40, 253-261
15. Munroe DJ, Haas M, Brie E, Whitton T, Aburatani H et al. (1994) IRE-Bubble PCR: a rapid method for efficient and representative amplification of human genomic DNA sequences from complex sources. Genomics 19, 506-514
16. Noben-Trauth K, Naggert JK, North MA, Nishina PM (1996) A candidate gene for the mouse mutation tubby. Nature 380, 534-538
17. Remmers EF, Longman RE, Du Y, O'Hare A, Cannon GW et al. (1996) A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Nat Genet 14, 82-85
18. Seldin MF, Mott D, Bhat D, Petro A, Kuhn CM et al. (1994) Glycogen synthase: a putative locus for diet-induced hyperglycemia. J Clin Invest 94, 269-276
19. Solanes G, Vidal-Puig A, Grujic D, Flier JS, Lowell BB (1997) The human uncoupling protein-3 gene. J Biol Chem 272, 25433-25436
20. Stam P, van Ooijen JW (1995) Joinmap (tm) version 2.0: software for the calculation of genetic linkage maps. (Wageningen, The Netherlands: Centre for Plant Breeding and Reproduction Research)
21. Taylor BA, Phillips SJ (1996) Detection of obesity QTLs on mouse chromosome 1 and 7 by selective DNA pooling. Genomics 34, 389-398
22. Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB (1997) UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Commun 235, 79-82
23. Warden CH, Fisler JS, Shoemaker SM, Wen P-Z, Svenson KL et al. (1995) Identification of four chromosomal loci determining obesity in a multi-factorial mouse model. J Clin Invest 95, 1545-1552
24. Woon PY, Osoegawa K, Kaisaki PJ, Zhao B, Catanese J et al. (1998) Construction and characterization of a 10-fold genome equivalent rat P1-derived artificial chromosome library. Genomics 50, 306-316